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Between 1977 and 1996, cytogenetic investigations were performed on 182 childhood (< or = 16 yr) acute lymphoblastic leukemias (ALL), constituting 94% (182 of 194) of all ALL patients diagnosed and treated at the Departments of Pediatrics, Lund and Malmo University Hospitals, Sweden, during these two decades. The cytogenetic analyses were successful in 152 cases (84%). The failure rate was higher

Popular Abstract in Swedish Reaktiva syreföreningar s.k. ROS uppstår naturligt i den syrerelaterade metabolismen eller i andra processer och den orsakar skador på essentiella föreningar i cellen såsom DNA, proteiner och fetter. Denna oxidation ligger till grund för många allvarliga sjukdomar hos människor som t.ex. viss typ av cancer och Alzheimers och man tror även att den ligger bakom andra åkomReactive oxygen species (ROS) consisting of various oxygen-based free radicals as well as other reactive non-radical species produced in O2-related metabolism or through other processes are involved in the oxidation of such vital biomolecules as DNA, proteins and lipids. The types of oxidation represented here are known to cause many different diseases and disorders in human beings, such as cancer

INTRODUCTION: Branched iliac stent-grafts (bSG) have recently been developed in order to preserve internal iliac artery (IIA) flow in patients with aneurysmal or short common iliac arteries. The aim of this study is to evaluate a single-center experience with bSG for the IIA. METHODS: Twenty-two male patients (70 (IQR 65-79) years old) underwent EVAR with 23 bSG (1 bilateral repair) between Septem

Background: Chronic suppurative otitis media (CSOM) is an important cause of hearing loss in children and constitutes a serious health problem globally with a strong association to resource-limited living conditions. Topical antibiotics combined with aural toilet is the first-hand treatment for CSOM but antimicrobial resistance and limited availability to antibiotics are obstacles in some areas. T

Aims: Mechanical ventilation practices in patients with cardiac arrest are not well described. Also, the effect of temperature on mechanical ventilation settings is not known. The aims of this study were 1) to describe practice of mechanical ventilation and its relation with outcome 2) to determine effects of different target temperatures strategies (33 °C versus 36 °C) on mechanical ventilation s

Jordan has one of the lowest available water supplies in the world; meanwhile Jordan has seen large increase in population and refugee’s fluxes, leading to an increase in water demand [1]. To address this unprecedented water scarcity, Jordan’s water must be used where its social and economic value is highest. Jordan must treat and reuse virtually every drop of water. It is expected to have more th

PURPOSE: Isoform-specific tumor estrogen receptor β (ERβ) expression may hold prognostic information in breast cancer, especially among endocrine-treated breast cancer patients. The study's purpose was to evaluate ERβ isoform 1 (ERβ1) expression in relation to tumor characteristics, ESR2 genotypes, and prognosis in different treatment groups.EXPERIMENTAL DESIGN: A population-based prospective coho

BACKGROUND: Diabetic kidney disease (DKD) remains one of the leading causes of premature death in diabetes. DKD is classified on albuminuria and reduced kidney function (estimated glomerular filtration rate (eGFR)) but these have modest value for predicting future renal status. There is an unmet need for biomarkers that can be used in clinical settings which also improve prediction of renal declin

PURPOSE: The prevalence of iron deficiency (ID) in Left Ventricular Assist Device (LVADs) recipients is not known nor has the association between ID and peak oxygen uptake (VO2) been reported. The aim of this study was to study to investigate the prevalence of ID in this population and the association between ID and VO2. METHODS: Data was included from LVAD recipients at Rigshospitalet, Denmark (D

Objective Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3′ UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast canc

Objectives To describe clinical history and ultrasound findings in patients with tubal carcinoma. Methods Patients with a histological diagnosis of tubal cancer who had undergone preoperative ultrasound examination were identified from the databases of 13 ultrasound centers. The tumors were described by the principal investigator at each contributing center on the basis of ultrasound images, ultra

Popular Abstract in Danish Børn og især piger med spændingshovedpine (på engelsk tension-type headache,TTH) har en høj forekomst på verdensplan og betyder for børnene en risiko for skolefravær, medicin over forbrug og vedvarende hovedpine. Den viden, der findes om fysiske faktorers sammenhæng med hovedpine, er begrænset, ligesom viden og dokumentation for interventioner er det. Det overordnede målTension-type headache (TTH) in children and especially girls is a prevalent problem worldwide, and means there is a risk of school absenteeism, medication overuse and persistent headache. Knowledge about the associated physical factors is limited, as is knowledge on evidence based interventions. The overall aim of this thesis was to examine the associations of physical factors with frequent or chr

BACKGROUND: Autonomous cortisol secretion in patients with adrenal incidentalomas is associated with increased mortality, but detailed information about the risk associated with specific levels of autonomous cortisol secretion is not available.OBJECTIVE: To measure the association between mortality and levels of autonomous cortisol secretion in patients with adrenal incidentalomas.DESIGN: Retrospe

Purpose: To determine the prevalence and characteristics of Charles Bonnet Syndrome (CBS) and its relation to visual field loss (VFL) in patients with open-angle glaucoma (OAG). Design: Prospective, cross-sectional study. Participants: Adult patients (n = 337) with manifest OAG with verified VFL and without significant macular disease or extraocular conditions known to cause visual hallucinations.

Tendons fulfill an important musculoskeletal function by enabling energy-efficient force transmission between muscles and bones. The tendon is a collagen-rich connective tissue that adapts to mechanical loading through mechanobiological processes. The tendon contains a hierarchical collagen fiber structure that displays complex mechanical behaviour by storing and dissipating energy. Current unders

Background and Objective: The number of reports on suspected drug-induced memory impairment submitted to the US Food and Drug Administration increased 30-fold from 2000 to 2022. Drugs are the most common cause of reversible dementia. However, there is very little research on drug-induced cognitive impairment. The aim of this study was to investigate if and how an assessment of cognitive safety was

Context: For nonazoospermic infertile men with elevated sperm DNA fragmentation (SDF), it is unclear whether the use of testicular sperm for intracytoplasmic sperm injection (ICSI) may offer advantages over ejaculated sperm. Objective: To determine whether ICSI outcomes (fertilisation rate, pregnancy rate, miscarriage rate, and live birth rate) are better with testicular sperm than with ejaculated

Fog makes a significant contribution to the hydrology of a wide range of important terrestrial ecosystems. The amount and frequency of fog immersion are affected by rapid ongoing anthropogenic changes but the impacts of these changes remain relatively poorly understood compared with changes in rainfall. Here, we present the design and performance of a novel experiment to actively manipulate low ly

PURPOSE: Clinical relapse is the major threat for patients with myelodysplastic syndrome (MDS) undergoing hematopoietic stem-cell transplantation (HSCT). Early detection of measurable residual disease (MRD) would enable preemptive treatment and potentially reduced relapse risk.METHODSPatients with MDS planned for HSCT were enrolled in a prospective, observational study evaluating the association b

IntroductionGlobal water scarcity necessitates innovative approaches to water treatment. Membrane technology has emerged as a key solution, demonstrating its effectiveness across a range of applications, from seawater desalination using reverse osmosis to wastewater treatment with membrane bioreactors. This presentation will introduce three novel water treatment concepts based on membrane technolo