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The construction of episodic memory is an automatic process. Event segmentation theory proposed that segmentation of the continuous perceptual stream into separate memory events occurs when changes in external boundaries lead to changes in internal perceptual and conceptual boundaries. The influence of perceptual and conceptual boundaries on episodic memory encoding has been the subject of intensi
Cytostatika är läkemedel som används för att behandla cancer genom att hämma eller stoppa celldelning. De används även som immunhämmande medel, till exempel vid organtransplantationer och autoimmuna sjukdomar. Eftersom dessa läkemedel påverkar cellers tillväxt kan de vara skadliga även i mycket små mängder om de hamnar i miljön. Cytostatika har upptäckts i ytvatten, grundvatten och dricksvatten i Introduction: Cytostatic pharmaceuticals are increasingly detected in the aquatic environment, raising concerns due to their persistence and toxicity. Background: Conventional wastewater treatment processes do not effectively remove these compounds. Advanced oxidation processes, such as ozonation, are needed to degrade cytostatic pharmaceuticals during wastewater treatment. However, these process
Lake Victoria is Africa’s largest freshwater lake by area shared by three countries: Uganda, Kenya, and Tanzania. The lake supports the economic development of the region through transport and fishing as well as recreational and tourism activities in the three countries. The main ports on the lake are Kisumu, Mwanza, Bukoba, Entebbe, Portbell, and Jinja served by several train ferry services for b
The aim of this research project was to create a bioinformatic image analysis pipeline for the investigation of lymphocytes in healthy human lungs. The lung is an important organ to study as it provides a fast way for pathogens to enter the body. Therefore, the pulmonary immune system must be further investigated in both healthy and diseased tissue. In order to do comparative studies, we need to c
Background & Aims The risk of hepatocellular carcinoma (HCC) in primary sclerosing cholangitis (PSC) is unclear. Studies indicate a low risk for HCC questioning the rationale for current HCC surveillance guidelines. This study explores the risk of HCC in a longitudinal multicenter cohort with over 3.000 PSC-subjects. Approach & results Subjects with well characterized PSC (n=3.071) were fo
DISA is an international company in the foundry industry that has a goal of being able to monitor their 250 different casting machines worldwide. A massive amount of information can be retrieved from the machines and by evaluating this information you can get an indication of how well the machines operates. The information is stored as meassured values at the customer site but is not used any furt
The common genetic variants associated with complex traits typically lie in noncoding DNA and may alter gene regulation in a cell type-specific manner. Consequently, the choice of tissue or cell model in the dissection of disease associations is important. We carried out an expression quantitative trait loci (eQTL) study of primary human osteoblasts (HOb) derived from 95 unrelated donors of Swedis
Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 mutations who were diagnosed with invasive breast cancer under age 40 and 1,190 BRCA1 carriers without breast cancer diagnosis over age 35. We took forward 96 SNPs for replication in another 5,986 BRCA1 carriers (2,974 indivi
Objectives: To investigate gender differences in daily smoking prevalence in different age groups in southern Sweden. Methods: The 2004 public-health survey in Skåne is a cross-sectional study. A total of 27,757 persons aged 18-80 years answered a postal questionnaire, which represents 59% of the random sample. A logistic regression model was used to investigate the associations between gender and
Background: Studies from Sweden have reported association between immigrant status and incidence of cardiovascular diseases. The nature of this relationship is unclear. We investigated the relationship between immigrant status and risk of heart failure (HF) hospitalization in a population-based cohort, and to what extent this is mediated by hypertension and life-style risk factors. We also explore
Recent studies on young men from the general population have demonstrated geographic and ethnic differences in semen quality. The aim of this study was to investigate whether reported ethnic differences in semen quality might be associated with the maternally derived CAG and GGN polymorphisms in the androgen receptor gene or paternal ethnicity. In total 114 military conscripts from Latvia were inc
Objective: To analyse if predictors of radiographic progression differ between patients treated with or without prednisolone in early rheumatoid arthritis (RA). Radiographs of hands and feet were assessed using the modified Sharp/van der Heijde score and radiographic progression was defined as an increase in the total Sharp score above 5.8 (the smallest detectable change). Design: Prospective, ran
Background: Laryngo-pharyngeal reflux (LPR) is assumed to be the most common cause of posterior laryngitis (PL). Since LPR is found in healthy subjects, and PL patients are not improved by acid-reducing therapy, other aetiologies to PL must be considered. The aims of this study in PL were to investigate the prevalence of acid reflux in the proximal oesophagus and functional gastrointestinal sympto
Objective: To determine whether preterm birth is associated with epilepsy in a national cohort of adults aged 25-37 years. Methods: We conducted a national cohort study of 630,090 infants born in Sweden from 1973 through 1979, including 27,953 born preterm (< 37 weeks), followed from 2005 to 2009 for 1) hospitalization for epilepsy and 2) outpatient and inpatient prescription of antiepileptic drug
OBJECTIVE-This study assessed insulin and glucagon secretion in relation to insulin sensitivity in Caucasian women who develop impaired glucose tolerance (IGT) versus those who maintain normal glucose tolerance (NGT) over a 12-year period. RESEARCH DESIGN AND METHODS-At baseline and after 3, 8, and 12 years, glucose tolerance (75-g oral glucose tolerance test), insulin sensitivity (euglycemic-hype
