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Molecular Epidemiology of Breast Cancer

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen i världen bland kvinnor och bara i Sverige insjuknar varje år runt 7000 personer. Vi vet att omkring 10-15% av fallen troligen beror på ärftliga faktorer och det har under senare tid gjorts stora insatser för att klargöra exakt vilka arvsanlag som har betydelse för utveckling av sjukdomen. Under början av 90-talet identifieradeHereditary breast cancer constitutes a considerable fraction of the total number of breast cancer cases occurring each year. Up until recently very few breast cancer predisposing genes were known, but many new common polymorphisms contributing to increased cancer susceptibility are continuously being identified. This thesis has focused on familial breast cancer and identifying as well as investi

Every 1,000 steps matter : incremental reductions in metabolic syndrome risk in Japanese office workers

Background: Several studies have investigated the association between metabolic syndrome (MetS) and physical activity (PA). However, further research is needed using objective measures of PA in free-living conditions, while also accounting for the time-variant nature of MetS. This study aimed to: (1) investigate the association between wearable device-measured step count and 5-year MetS incidence

Cognitive and psychiatric symptoms are associated with walking difficulties in mild Parkinson’s disease

Objective: To investigate the association of different aspects of cognitive impairment, depression and anxiety with walking difficulties in daily life in persons with mild PD.Background: Walking difficulties in daily life are common among persons with Parkinson’s disease (PD) and may cause falls and near falls, limitations in activity, restrictions in participation and decrease in quality of life.

Succession in two plots at "Kungsmarken" between 1952 and 2005 with different historical management

Abstract The main influences on growing conditions in pastures and hayfields are grazing and mowing, which regulate the species struggle for space and resources. If the management ceases, this will contribute to a change of the vegetation. A succession starts where the plant cover gradually will change according to a specific pattern. After some time a few competitive species, previously disfavou

Klimatanpassad byggnad för varma somrar och kalla vintrar

Outdoor climate has considerable impact on the indoor climate and it is therefore important to adapt the buildings to the climate. This thesis shows how to improve indoor climate in a climate which it is hot, dry in the summer and cold in the winter. My investigative unit is a middle class house in the town Baalbek in Lebanon and the purpose of the study is to come up with proposals on possible so

MODIS NDVI satellite data for assessing drought in Somalia during the period 2000-2011

Popular science Using remote sensing to assess drought in Somalia Somalia, the country in East Africa in a region referred to as Horn of Africa is in a civil war, conflict and unrest since 1991. The prolonged conflict increases the impact of droughts in the country which is already prone to drought continuously. The country is frequently exposed to drought, occurring moderately every 3-4 years a

Allergic eosinophil-rich inflammation develops in lungs and airways of B cell-deficient mice

Immunoglobulins (Ig), particularly IgE, are believed to be crucially involved in the pathogenesis of asthma and, equally, in allergic models of the disease. To validate this paradigm we examined homozygous mutant C57BL/6 mice, which are B cell deficient, lacking all Ig. Mice were immunized intraperitoneally with 10 micrograms ovalbumin (OVA) plus alum, followed by daily (day 14-20) 30 min exposure

Antimicrobial resistance in urinary pathogens among Swedish nursing home residents remains low: a cross-sectional study comparing antimicrobial resistance from 2003 to 2012

Background: There are several risk factors for the colonisation, infection and spreading of antibiotic resistant bacteria among elderly residents of nursing homes. An updated estimate of the native prevalence of antimicrobial resistance in uropathogens among Swedish nursing home residents is needed. Methods: Urine specimens were collected for culture and antimicrobial susceptibility testing agains

The effect of endogenously released glucose, insulin, glucagon-like peptide 1, ghrelin on cardiac output, heart rate, stroke volume, and blood pressure

Background: Ingestion of a meal increases the blood flow to the gastrointestinal organs and affects the heart rate (HR), blood pressure and cardiac output (CO), although the mechanisms are not known. The aim of this study was to evaluate the effect of endogenously released glucose, insulin, glucagon-like peptide 1 (GLP-1), ghrelin on CO, HR, stroke volume (SV), and blood pressure. Methods: Eleven

Expression and prognostic significance of the polymeric immunoglobulin receptor in epithelial ovarian cancer

Background: High expression of the polymeric immunoglobulin receptor (PIGR) has previously been associated with a favourable prognosis in a few cancer forms, but its expression and relationship with clinical outcome in epithelial ovarian cancer (EOC) has not yet been reported. The aim of this study was therefore to examine the clinicopathological correlates and prognostic significance of PIGR expr

Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome

Objective The complex genetic aetiology underlying irritable bowel syndrome (IBS) needs to be assessed in large-scale genetic studies. Two independent IBS cohorts were genotyped to assess whether genetic variability in immune, neuronal and barrier integrity genes is associated with IBS. Design 384 single nucleotide polymorphisms (SNPs) covering 270 genes were genotyped in an exploratory cohort (93

Improving the Efficiency of Gas Engines using Pre-chamber Ignition

The aim of this project is to explore and understand the combustion phenomenon in engines operating on gaseous fuels, and develop technologies as an alternative to the present diesel engine technologies for heavy duty applications; which are facing severe challenges like stringent emissions norms, high technology costs and unsustainable fuel supply. The studies presented in this thesis focus on th

Single nucleotide polymorphisms in the 20q13 amplicon genes in relation to breast cancer risk and clinical outcome

The 20q13 region is frequently amplified/overexpressed in breast tumours. However, the nature of this amplification/overexpression is unknown. Here, we investigated genetic variation in five 20q13 amplicon genes (MYBL2, AURKA, ZNF217, STK4 and PTPN1) and its impact on breast cancer (BC) susceptibility and clinical outcome. As a novel finding, four polymorphisms in STK4 (rs6017452, rs7271519) and A

Sweah verksamhetsberattelse 2019

Nationella forskarskolan om åldrande och hälsa Fastställd av SWEAH:s styrelse 2020-03-16 Verksamhetsberättelse 2019 Nationella forskarskolan om åldrande och hälsa www.sweah.lu.se Nationella forskarskolan om åldrande och hälsa Verksamhetsberättelse 2019 2 Innehållsförteckning sida Styrelse 3 Partners 4 Forskarskolans ledning och administration 4 ◦ Pedagogisk arbetsgrupp 5 Anslutna doktorander 5 Dis

https://www.sweah.lu.se/sites/sweah.lu.se/files/sweah_verksamhetsberattelse_2019.pdf - 2026-05-07

MSB Countering information influence activities handbook

Countering information influence activities A handbook for communications officers Countering information influence activities A handbook for communications officers Countering information influence activities – A handbook for communications officers This publication is also available in Swedish Att möta informationspåverkan – Handbok för kommunikatörer Order No: MSB1261 - Revised December 2018 IS

https://www.psychologicaldefence.lu.se/sites/psychologicaldefence.lu.se/files/2024-11/MSB_Countering_information_influence_activities_handbook.pdf - 2026-05-07

Holmberg

Holmberg Working Papers in Scandinavian Syntax 101, 29–48 The syntax of the V3 particle så in the Swedish left periphery Anders Holmberg Newcastle University Abstract A characteristic feature of the left periphery in Mainland Scandinavian is the particle så occurring optionally between certain fronted constituents and the finite verb in root clauses. Following Eide (2011) the particle will be anal

https://projekt.ht.lu.se/fileadmin/user_upload/sol/ovrigt/projekt_grimm/working_papers/2018-dec/Holmberg.pdf - 2026-05-04

Introducing FIRE

Introducing FIRE September 2025 FIRE: A Framework for Integrating Human Rights and Gender Equaliy in the Triple Planetary Crisis MATTHEW SCOTT & MO HAMZA FIRE Exposure, Vulnerability & Capabilities Information, Participation & Access to Justice Governance Systems & Structures Fundamental Rights & Equality Copyright: The authors Publication design by RWI Report published September 2025 The views an

https://rwi.lu.se/wp-content/uploads/2025/09/Introducing-FIRE-1.pdf - 2026-05-04

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Postal address Box 117, 221 00 Lund Visiting address LUX, Bldg. B, Helgonavägen 3 Telephone +46 46 222 83 15 Email kristina.arnrup_thorsbro@kansliht.lu.se Website www.ht.lu.se Facul ty Board ’s work ing commit tee General syllabus for third-cycle studies for the Degree of Doctor in East and South-East Asian Studies This syllabus was approved by the Board of the Joint Faculties of Humanities and Th

https://www.ht.lu.se/fileadmin/user_upload/ht/filserver/doktorand/studieplaner-engelska-2023/East_and_South-East_Asian_studies.pdf - 2026-05-04

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Case assignment and the linear order of coordinated verbs* Jim Wood Yale University Einar Freyr Sigurðsson The Árni Magnússon Institute for Icelandic Studies Oddur Snorrason Queen Mary University of London Abstract In this paper, we draw on corpus data to show that in Icelandic, verbs that assign distinct cases can be coordinated and share a single object: the verb on the right determines the case

https://projekt.ht.lu.se/fileadmin/user_upload/sol/ovrigt/projekt_grimm/working_papers/2022-dec/Case_assignment_and_coordinated_verbs__WPSS_format_.pdf - 2026-05-04