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Key points IL1RAP is overexpressed on candidate AML stem cells and is a promising target for antibody-based therapy.

The role of CD4+ T cells in atherosclerosis has been shown to be dependent on cytokine cues that regulate lineage commitment into mature T helper sub-sets. In this study, we tested the roles of IL-1R1 and MyD88 signalling in CD4+ T cells in atherosclerosis. Methods and results We transferred apoe-/-myd88\+/\+ or apoe-/-myd88-/- CD4+ T cells to T-A nd B-cell-deficient rag1-/-apoe-/- mice fed high f

Brevmall_Mac 2008 - Linnéuniversitetet Överenskommelse Datum: 2025-10-07 Dnr: Överenskommelse mellan Saco-S och Linnéuniversitetet om RALS-processen 2025 Arbetsgivarens delegation och Saco-S delegation är överens om följande inför genomförandet av lönesättande samtal vid Linnéuniversitetet. Revisionstidpunkten ska vara 2025-10-01. Överenskommelsen omfattar anställda som har lön 2024-10-01 eller ti

https://www.saco.se/globalassets/lokala-akademikerforeningar/statlig/linneuniversitetet/dokument/overenskommelse-rals--25.pdf - 2026-06-02

Background: Aortic stenosis (AS) is the most common valvular heart disease in developed countries, confers high mortality in advanced cases, but can effectively be reversed using endovascular or open-heart surgery. We evaluated the association between AS and neighborhood socioeconomic status (NSES). Methods: We used Swedish population-based nationwide registers and an echocardiography screening co

Popular Abstract in Swedish Den sydafrikanske författaren J. M. Coetzee, nobelpristagare 2003, är en komplex författare som räknas till en av samtidens största. Han har en unik politisk hållning i sina romaner och vägrar konsekvent att ge några enkla lösningar, istället drar han in läsaren och tvingar henne att bli delaktig i verkens problematik. I denna studie, den första avhandlingen på svenska This dissertation is a study of In the Heart of the Country (1977), Waiting for the Barbarians (1980), Age of Iron (1990), Disgrace (1999), Diary of a Bad Year (2007), and Summertime (2009) written by J. M. Coetzee. The aim of the dissertation is to analyze these works of fiction using four postcolonial aspects that function as consistent themes in the novels. The aspects are; the relationship bet

Blood vessels and adjacent cells form perivascular stem cell niches in adult tissues. In this perivascular niche, a stem cell with mesenchymal characteristics was recently identified in some adult somatic tissues. These cells are pericytes that line the microvasculature, express mesenchymal markers and differentiate into mesodermal lineages but might even have the capacity to generate tissue-speci

The climate is changing, something that many scientists correlate to increased emissions of greenhouse gases. The effluent that is considered to have the highest impact on global warming is carbon dioxide, when effect and quantity are taken into account. Most projections however, show that the effect is reversible if the amount of carbon dioxide emissions discharged to the atmosphere is decreased.

Based upon earlier experimental work by our group, we have started a human immuno-gene therapy study. The goal is to study the effects of immunisation with autologous tumour cells expressing gene sequences for human interferon-gamma For more than two decades we have sought for efficient treatment against malignant gliomas. Our most successful treatment in the animal models is immuno-gene therapy w

Abstract in Danish I et kursus med 12 studerende i 3 tropiske lande og 36 internationale studerende i Danmark arbejdede de studerende virtuelt sammen i grupper med deltagere i både Danmark og i udlandet. De studerende opnåede samme faglige udbytte som ved tidligere kursusgange med studerende kun i Danmark, men lærte mere om projektsamarbejde per distance og forskellige præsentationsformer. Der var

Aortic stenosis (AS) shares risk factors with atherosclerotic vascular disease. Carotid intima-media thickness (IMT) and plaque may reflect the cumulative damage from exposure to different atherosclerotic risk factors. We examined the relationship of carotid IMT and plaque with incident AS in a prospective population-based study.

BACKGROUND AND PURPOSE: The Coronary Artery Disease Genome-Wide Replication and Meta-Analysis Study (CARDIoGRAM) reported 25 single-nucleotide polymorphisms (SNPs) on 15 chromosomes to be associated with coronary artery disease (CAD) risk. Because common vascular risk factors are shared between CAD and ischaemic stroke (IS), these SNPs may also be related to IS overall or one or more of its pathog

Objective: IgG antibodies against apolipoprotein A-I (ApoA-I) have been found to be elevated in subjects from the general population with clinically manifest cardiovascular disease and in myocardial infarction patients with an adverse prognosis. Here, we investigated whether these antibodies are prospectively associated with carotid artery disease progression and with the risk for first-time cardi

Arbete kan vara en stor del av en individs liv och värderas ofta högt av samhället. Personer med psykisk ohälsa är en grupp som riskerar att hamna utanför arbetsmarknaden. Arbetsrehabilitering är ett sätt att minska utanförskap för denna grupp. Många som arbetar med arbetsrehabilitering för personer med psykisk ohälsa är arbetsterapeuter. Meningsfulla aktiviteter är ett koncept som genomsyrar all

Background: Imputation of untyped markers is a standard tool in genome-wide association studies to close the gap between directly genotyped and other known DNA variants. However, high accuracy with which genotypes are imputed is fundamental. Several accuracy measures have been proposed and some are implemented in imputation software, unfortunately diversely across platforms. In the present paper,

Background Metastatic melanoma is still one of the most prevalent skin cancers, which upon progression has neither a prognostic marker nor a specific and lasting treatment. Proteomic analysis is a versatile approach with high throughput data and results that can be used for characterizing tissue samples. However, such analysis is hampered by the complexity of the disease, heterogeneity of patients

6_Ingrid Holmberg9dec21final_mod LTHs 11:e Pedagogiska Inspirationskonferens, 9 december 2021 Abstract— Studie- och karriärvägledarna vid LTH har under många år arbetat aktivt med retentionsarbete (uppföljning av studieresultat). Jag har ofta undrat över hur studenterna upplever samtalen och vad samtalen har lett till. Vissa studenter träffar vi många gånger, andra träffar vi enskilt en gång eller

https://www.lth.se/fileadmin/cee/genombrottet/konferens2021/A4_Holmberg.pdf - 2026-06-02

Lokalt samarbetsavtal för AkademikerAlliansen i XX kommun Detta samarbetsavtal avser lokal samverkan mellan de förbund inom AkademikerAlliansen som väljer teckna detta avtal. 1.0 Ändamål 1.1 Avtalets syfte är att reglera förutsättningarna som ska gälla mellan de förbund som ingår i föreningen. 2.0 Bildande av den lokala föreningen 2.1 Utgångspunkten för att bilda lokal förening är att det är frivi

https://www.saco.se/globalassets/lokala-akademikerforeningar/kommun-och-region/akademikeralliansen/dokument/alliansforening/mall_lokalt-samarbetsavtal_akademikeralliansen_2023.docx - 2026-06-02