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Hereditary syndromes causing colorectal cancer include both polyposis and non-polyposis syndromes. Overlapping phenotypes between the syndromes have been recognized and this make targeted molecular testing for single genes less favorable, instead there is a gaining interest for multi-gene panel-based approaches detecting both SNVs, indels and CNVs in the same assay. We applied a panel including 19

Background Comparison of patients with coronary heart disease and controls in genome-wide association studies has revealed several single nucleotide polymorphisms (SNPs) associated with coronary heart disease. We aimed to establish the external validity of these findings and to obtain more precise risk estimates using a prospective cohort design. Methods We tested 13 recently discovered SNPs for a

Background Ezrin is a cytoskeletal protein involved in tumour growth and invasion. Ezrin expression has been suggested to play a role in metastasis in paediatricosteosarcoma and rhabdomyosarcoma. Aim To evaluate the prognostic role of ezrin in a large series of soft tissue sarcoma of the extremities and trunk wall. Methods Ezrin expression was evaluated by immunohistochemistry on tissue microarray

BACKGROUND: Although 2-20% of breast cancer patients develop a contralateral breast cancer (CBC), prognosis after CBC is still debated. Using a unique patient cohort, we have investigated whether time interval to second breast cancer (BC2) and mode of detection are associated to prognosis. METHODS: Information on patient-, tumour-, treatment-characteristics, and outcome was abstracted from patien

In 2007, a new regulatory framework in the European economic area opened up to a less regulated market. Now, share trading was not only done on the main stock markets but could also take place at alternative trading facilities. The deregulation led to greater competition, better consumer protection and a fragmented market with alternative trading facilities, which are subject to less regulation. T

Title: Shopper Mode - Shopper marketing from a shopper perspective Date of the Seminar: Lund, 2012-05-30 Course: BUSN29. Master thesis Authors: Charlotte Borgeke Nilsson & Caroline Lundström Ek Advisor: Karin Alm Keywords: Shopper Marketing, shopper perspective, shopper mode, Swedish pharmacy market, Apoteket Hjärtat The thesis purpose: The purpose of this research is to contribute to a greate

From the year of 2000 to 2010 the increase in expenditures for the Swedish households on furnishings, household equipment and routine maintenance of the house is 67%, for clothing and footwear the increase is 50%. Our total consumption from the same years has increased by 23%. I started this project by researching on the human sociology in relation to private consumption. Why do we spend so much

At present there are no concrete guidelines how to calculate the pressure resistance capacity of the timber at the load perpendicular to grain. The test options ASTM, CEN and ICO gives three different results in testing of an equal body. With this knowledge the value for the characteristic compressive strength capacity of the pressure perpendicular to the grain will be reduced to 2.7 MPa. The reduc

Ickekonstitutionella regeringsförändringar har varit ett stort problem i Afrika sen avkoloniseringen och militärkupper har varit en minst lika vanlig form av regeringsbyte som demokratiska val. Afrikanska unionen (AU) har sen den bildades 2001 utvecklat den afrikanska internationella rätten för att kunna hantera dessa situationer. AU:s föregångare Organisationen för afrikansk enighet (OAU) hade inUnconstitutional changes of government has been a major problem in Africa since decolonization with military coups being a more common way of changing government than democratic elections. The African Union (AU) was established in 2001 and has since then provided a significant development of the African law, not the least in the branch of law covering the AU response to unconstitutional changes of

Det finns ett stort mörkertal vid våldtäkter, vilket betyder att väldigt få anmäler att de har blivit våldtagna. Överlag är det ett stort mörkertal vid sexualbrott och underökningar tyder på att endast 10-20 % av alla sexualbrott anmäls. Ett problem är att många inte vill erkänna att de blivit utsatta, vilket gör att det blir svårt att få reda på hur stort mörkertalet faktiskt är. För att få fram There is a large dark figure of rapes, which means that very few report that they have been raped. Overall is it a large dark figure of sexual crimes and it is estimated that only 10-20 % of all sexual crimes are reported. One problem is that many do not want to admit that they are exposed, so it becomes difficult to know how large the dark figure of crime actually is. To obtain the dark figure of

Background and Purpose: Coagulation factor XI (FXI) has an important role in the propagation and stabilization of a thrombus upon vessel injury. High FXI levels have been implicated in thrombotic diseases including ischemic stroke. The aim of our study was to investigate whether FXI gene (F11) variants are associated with ischemic stroke. Methods: The discovery sample, the Sahlgrenska Academy Stud

Background: We have previously demonstrated that elevated concentrations of tumour-associated trypsin inhibitor (TATI) in both tumour tissue (t-TATI) and in serum (s-TATI) are associated with a poor prognosis in colorectal cancer patients. It was also found that s-TATI concentrations were lower in patients with rectal cancer compared to patients with colon cancer. In this study, we investigated th

Background: We have previously reported that expression of the RNA-and DNA-binding protein RBM3 is associated with a good prognosis in breast cancer and ovarian cancer. In this study, the prognostic value of immunohistochemical RBM3 expression was assessed in incident cases of malignant melanoma from a prospective population-based cohort study. Methods: Until Dec 31(st) 2008, 264 incident cases of

The high false negative rates for initial prostate biopsies refer a large number of the men for repeat biopsies each year. Therefore, biomarkers associated with high risk of the presence of malignancy in histologically benign biopsies could provide a tool to discriminate the patients who need repeat biopsy or intensive follow-up from those who do not. Here we examined the diagnostic applicability

Rationale: Atherosclerotic plaques that give rise to acute clinical symptoms are typically characterized by degradation of the connective tissue and plaque rupture. Experimental studies have shown that mechanisms to repair vulnerable lesions exist, but the rate of remodeling of human plaque tissue has not been studied. Objective: In the present study, we determined the biological age of different

Folate's role in breast cancer development is controversial. Not only estrogen receptor (ER) alpha status, but also ERbeta status of tumors may have confounded results from previous epidemiological studies. We aimed to examine associations between plasma folate concentration and postmenopausal breast cancer defined by ER status. This nested case-control study, within the Malmö diet and cancer coho

Most acute cardiovascular events are caused by rupture of an atherosclerotic plaque. The incidence of cardiovascular events increases with age and inflammation is generally considered to be the main cause of increased plaque vulnerability. However, the relationship between age and plaque inflammation has not yet been fully clarified. The aim of our study was to determine if age-dependent plaque vu

Ulceration of primary melanomas is associated with poor prognosis yet is reported to predict benefit from adjuvant interferon. To better understand the biological processes involved, clinicopathological factors associated with ulceration were determined in 1804 patients. From this cohort, 348 primary tumor blocks were sampled to generate gene expression data using a 502-gene cancer panel and 195 b

Recent epidemiological investigations have reported on the association between telomere length (TL) and a number of malignancies, including B-cell lymphoma (BCL). The reported results for BCLs are however inconsistent. We carried out a nested case-control study to determine whether TL is associated with future risk of BCL. Using quantitative polymerase chain reaction, the relative TL (i.e. the rat