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Background: The aim was to evaluate whether an artificial intelligence (AI)-based tool for the automated quantification of the total metabolic tumour volume (tMTV) in patients with Hodgkin lymphoma (HL) could support nuclear medicine specialists in lesion segmentation and thereby enhance inter-observer agreement. Methods: Forty-eight consecutive patients who underwent staging with [18F]FDG PET/CT
Chemical pollution is identified as a significant driver of biodiversity loss, raising concerns about the effectiveness of current environmental risk assessment (ERA) practices. Conventional ERA approaches primarily rely on the endpoints of mortality, growth, and reproduction, often failing to capture the full scope of potential effects that chemicals can have on organisms. This is potentially pro
INTRODUCTION: Amyloid-positron emission tomography (PET) is pivotal to Alzheimer's management, with the Centiloid standardizing measurements across tracers. AMYPAD trials (Diagnostic and Patient Management Study [DPMS] and Prognostic and Natural History Study [PNHS]) aimed to validate robust quantification in clinical settings. We report our comprehensive approach to amyloid-PET implementation, co
Aims/hypothesis: Type 1 diabetes develops gradually, and previous exposures may influence incidence. We aimed to assess the geographical variation in type 1 diabetes incidence in Sweden by considering all residential locations from birth to diagnosis in individuals aged 0–30 years, diagnosed between 2005 and 2022. Significant high- and low-risk clusters were identified for different life stage exp
Background: Anaemia is frequently recorded during preoperative screening and has been suggested to affect outcomes after surgery negatively.Objectives: The objectives were to assess the frequency of moderate to severe anaemia and its association with length of hospital stay.Design: Post hoc analysis of the international observational prospective 'Local ASsessment of VEntilatory management during G
OBJECTIVES: This study investigates the expansion of CAR T-cells and its association to treatment outcome.METHODS: Patients with aggressive B-cell lymphomas treated with anti-CD19 CAR T-cell therapy axicabtagene ciloleucel (axi-cel) at Skåne and Sahlgrenska University Hospitals from 2019 to October 2024 were included. CAR T-cells in peripheral blood were measured by flow cytometry. Association bet
Long-distance migrants face numerous challenges during their migration, with the spring migration timing being particularly important, as early arrival at the breeding grounds often enhances breeding success. Both innate and environmental factors influence migration timing in birds, and the earlier arrival of males than females is common among songbirds breeding in temperate zones. The great reed
Blood biomarkers have the potential to revolutionize Alzheimer's disease diagnosis, offering advantages over CSF and PET due to their accessibility, scalability and cost-effectiveness. This study evaluated the effectiveness of individual plasma biomarkers, such as phosphorylated Tau (pTau) 217, as well as biomarker combinations, with a focus on the pTau 217/β-Amyloid (Aβ) 1–42 ratio to predict amy
Background: Atrial fibrillation (AF) is a major risk factor for atherothrombotic complications but is often asymptomatic and undiagnosed. This study aimed to develop a machine learning model to distinguish between individuals with low and high risk of AF, using routinely collected diagnostic data from Swedish primary health care. Methods: Cases (n = 42,607, aged ≥ 45 years) with diagnosed new onse
Death is the prerequisite of life, life the prerequisite of death, just like chaos and order, light and shadow, joy and despair, love and grief, are each other's premises. When life breaks into pieces, despair may ensue, but darkness offers possibilities to tap into the light. The use of experiential somatic practices and creative expressions can reach deep and help illuminate conscious and uncons
This Further engagement article takes up Blok and Jensen's recent call, made through a Dialogues in Sociology Forum, to ‘invent around’ the work of Bruno Latour to highlight his continued relevance and contribution to the practice of sociology. It is proposed that one way in which Latour might be usefully invented around is by bringing his work, particularly on matters of concern, into greater rel
In 1993 the 73rd Amendment to the Indian Constitution came into force, affecting the Indian rural governing bodies, the Panchayati Raj Institutions (PRIs). The Amendment, at focal point for this thesis, provides a 33% reservation for women as members and as chairperson in the PRI's three-tier system. The reservation has led to a tremendous mobilization of women in the countryside, resulting in
Three new genera in the lichen family Teloschistaceae, i.e.: Josefhafellia for the former Caloplaca bellemerei group, Bagliettoella for the former Gyalolechia marmorata branch and Tsarenkoella for the former Caloplaca obscurella group are described and compared with closely related genera. The positions of the species Lacrima apostatica (basionym: Loekoesia apostatica) and Neoplaca sideritis (basi
Male childlessness in late adulthood is increasingly prevalent in rural China, indicating a critical need to understand the factors contributing to childlessness among rural men—an often-overlooked group in gerontological and childlessness research. While existing studies have explored individual-level predictors of childlessness over the life course and the implications of broader societal condit
BACKGROUND: Despite the high level of economic development in the Group of Seven (G7) countries, injury deaths remain a public health concern in these countries. This paper examines the contribution of injury deaths to changes in life expectancy (LE) and life disparity (LD) in the G7 countries.METHODS: We used annual data from the WHO mortality database to compute LE and LD during 2001-03 and 2017
Objective: Although patients prefer describing their problems using words, mental health interventions are commonly evaluated using rating scales. Fortunately, recent advances in natural language processing (i.e., AI-methods) yield new opportunities to quantify people's own mental health descriptions. Our aim was to explore whether responses to open-ended questions, quantified using AI, provide ad
Background: Surface electromyography is commonly used to elucidate the effect of anterior cruciate ligament injury on neuromuscular function. For comparisons, electromyography is normalized to a known value, such as peak activation during maximum voluntary isometric contractions. However, a knee injury may compromise one's ability to achieve a true maximal effort. A simple musculoskeletal model ma
Background: Developmental exposures to neurotoxic insecticides, as pyrethroids and chlorpyrifos are of growing concern. Objective: To study associations between low prenatal and childhood exposure to pyrethroids and chlorpyrifos and motor skills at age 7. Materials and methods: Data consisted of sub-samples of women and children from the Odense Child Cohort; 883 mother-child pairs with maternal ur
