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Quinoline-3-carboxamides (Q substances) are small molecule compounds with anti-inflammatory properties. In this study, we used one of these substances, Paquinimod, to treat a novel model for chronic liver inflammation and liver fibrosis, the NOD-Inflammation Fibrosis (N-IF) mouse. We show that treatment of N-IF mice significantly reduced inflammation and resulted in the regression of fibrosis, eve
Water security offers to the local population an adequate quality and quantity of water for health, economy, livelihoods and ecosystems. Hence, achieving basic levels of water security should be a priority in areas where access to fresh water is scarce. The Punata alluvial fan (Bolivia) is a semiarid zone and an important agricultural zone, where the main source of water is groundwater. Therefore,
To assess the benefits of introducing Agile practices, it is important to get a clear understanding of the baseline situation, i.e. the situation before their introduction. Without a clear baseline, we cannot properly assess the extent of impacts, both positive and negative, of introducing Agile practices. This paper provides a preliminary guideline to help researchers in capturing and reporting b
This paper reports a search for triboson W±W±W∓ production in two decay channels (W±W±W∓→ ℓ±νℓ±νℓ∓ν and W±W±W∓→ ℓ±νℓ±νjj with ℓ= e, μ) in proton-proton collision data corresponding to an integrated luminosity of 20.3 fb - 1 at a centre-of-mass energy of 8 TeV with the ATLAS detector at the Large Hadron Collider. Events with exactly three charged leptons, or two leptons with the same electric charg
In October 2014, the European Council agreed on a target of improving overall energy efficiency by at least 27 per cent by 2030. According to the European Council's conclusions, this target should not be translated into nationally binding targets. Nevertheless individual Member States are free to set higher national objectives if desired. However, it is difficult to assess the degree of ambition o
The present study investigates the significance of potential slip in the bracings of simply supported slender timber members. Three bracing configurations are considered. The first case is that of a timber beam braced at one point at mid-span, the second one braced at two points and the third one braced at three points. Possible slip in the bracing members can for example be due to joint deformati
This study analyses the implementation and sustainability of evidence-based community mental health services in the form of publicly financed Individual Placement and Support programs. Critical implementation components and program fidelity were assessed after one year. After two years, program fidelity was assessed once again. After three years, the programs’ sustainability was assessed and semi-
The orientation towards grand societal challenges can be seen as a new wave or paradigm for innovation policy. Such policy aims at system-wide transformation and is often referred to as system innovation policy. While insights from transition studies have provided novel and useful rationales for innovation policy targeting system-wide transformation, it remains unclear how to design, implement and
In this paper, we present the findings of a Universitas 21 (U21) Graduate Research Project collaboration between Pontificia Universidad Católica de Chile, the University of Nottingham, England, and Lund University, Sweden. This project brought together six doctoral candidates at various stages in their postgraduate careers. The students had conducted qualitative and quantitative inquiry into diver
This work demonstrates the sensitivity of lens antenna arrays operating at millimeter-wave (mmWave) frequencies. Considering a Rotman lens array in receive mode, our investigation focuses on its most imperative defect: aberration of electromagnetic (EM) energy. Aberration leads to spillover of electric fields to neighboring ports, reducing the lens' ability to focus the EM energy to a desired port
Rapid urbanization and the growth in the number of motorized vehicles has dramatically marginalized cycling in Chinese cities since the end of the 1990s. The deterioration in air quality and the urban environment is severely challenging urban livability and public health. The cities are seeking effective policies to alleviate these problems, and revitalizing bicycle transport has received increasi
Idag behandlas de flesta patienter som diagnostiserats med gliom, en otäck hjärntumör, med fotoner producerade i en linjäraccelerator på någon av landets strålbehandlingskliniker. Tumören växer inuti hjärnan på ett mycket aggressivt sätt, vilket gör den nästan omöjlig att bota. Det normala är att strålningen kombineras med cellgifter och kirurgi för att ge patienten så lång tid som är möjligt, tilIncreased accuracy in patient dosimetry in BNCT is needed. This need for more accurate individual patient dose estimations initiated this project at the Swedish BNCT facility at Studsvik. One possible way to achieve this is to use an HPGe detector. This project involves the complete construction and testing of such a system in a treatment representative environment.The system builds on an ORTEC GM
This thesis investigates the virtual meetings characteristics and policy intervention options in Chinese organizations. Virtual meetings can enable the communication of two or more parities in different locations with assistance of ICT technologies. It is thus possible for virtual meetings to substitute conventional physical face- o-face meetings without business travel and the associated environm
As some insect groups are declining at alarming rates, accurate and automated insect monitoring is needed to prioritize habitats for conservation. The dual-band entomological Scheimpflug lidar technique is a promising candidate method for real-time insect monitoring: it allows the detection of thousands of flying insects per day at high temporal and spatial resolutions. The signals contain a pleth
Light extinction is widely used to study particles in sprays, soot-forming combustion, and multiphase reactive flows. However, quantitative interpretation of extinction signals remains challenging when particles have a sufficiently large scattering albedo, meaning that incident photons are scattered much more than they are absorbed. This is especially true when experiments involve large apertures
In this thesis we consider different tests for unit roots in the presence of structural change. We present the theory that lies behind unit roots, what we mean by structural change and try to detect the instances that “breaks” occur in the data. When performing a unit root test, when there is a structural change the results are biased toward accepting a unit root. Therefore, special care must be t
The main sustainability goal of many small islands in the North Sea is to become self supplied in renewable energy in 20-30 years. The majority of the islands are trying to repeat Samsø‘s success – to make a transition towards energy sustainable system by new energy production from local renewable sources such as wind, solar and biomass. However, for other islands like Spiekeroog island, a tourist
