Filetype
Introduction: This study evaluated lipid identification using mass spectrometry. Background: Three main modes of acquisition are used in mass spectrometry of lipids; data-independent acquisition (DIA), data-dependent acquisition (DDA) and targeted acquisition. DIA is the most including one, yielding a complete but complex data set, while targeted is the least including one, basing acquisition on
The focus of this thesis is to examine how the civic identity of the second-generation migrants in Italy is constructed through media representations of migration, citizenship, and national belonging. Previous studies focused on migrants’ integration, which was based on their socio-economic situation, mobility, and assimilation process. I argue that these approaches are insufficient to explain how
Urban meteorology, the study of atmospheric phenomena in urban areas, is vital for understanding the dynamic interactions between rapid urbanization and environmental changes. Over the past two decades (2004–2024), urban heat islands (UHIs), extreme rainfall, pollution, and temperature anomalies have intensified, adversely affecting human health, infrastructure, and ecosystems worldwide. The prese
Abstract – Introduction: – Spinal disorders are among the biggest contributors to health care utilization (HCU).Objective: – To develop and externally validate a prediction model for high all-cause HCU (75th percentile during 1 year after the index date) among patients with spinal disorders visiting multidisciplinary secondary care clinics.Methods: – We developed and internally validated the model
Background Drug use disorder (DUD) clusters in families due partly to shared environment, including sibling influences. Low academic achievement (AA) in adolescence increases DUD risk. This study examined whether low AA in an older sibling causally increases DUD risk in younger siblings. Methods We studied all Swedish full sibling pairs (n = 309,666) born 1972–1985 and ≤ 5 years apart. Older sibli
Background: Tick-borne encephalitis (TBE) is a serious vector-borne neurological disease in Europe, with a complex transmission cycle involving ticks of genus Ixodes, animal hosts, environmental and climatic determinants. Methods: We modelled annual Geocoded Swedish TBE case data for the period 2005–2023 as a log-Gaussian Cox process in relation to population, environmental and climate data, and w
Background: Quantitative fecal immunochemical test (FIT) is widely used for colorectal cancer (CRC) screening, with substantial variation in positivity thresholds across countries. This study examines how these thresholds affect FIT's diagnostic performance for detecting CRC and advanced precancerous lesions (APCL). Methods: We analyzed data from a single round screening of 7398 men and women aged
The Swedish public library was founded in the years when the society in Sweden went from being a society of agriculture to industrialism. Modernism was sweeping over the country, everything was possible, which influenced the new society that was built. Now Sweden was going to be a true democracy with responsible and empathic citizens. One of the main tools in this process was to educate people, to
Background: Obesity is suggested to underlie development of other metabolic aberrations, but longitudinal relationships between metabolic factors at various ages has not been studied in detail. Methods: Data from 27,379 men and 32,275 women with in total 122,940 health examinations in the Västerbotten Intervention Project, Sweden and the Vorarlberg Health Monitoring and Prevention Programme, Austr
PURPOSE: To study newly diagnosed glaucoma patients given mono- or multi-therapy regarding differences in initial intraocular pressure (IOP) reduction, target IOP levels reached and influence of untreated baseline IOP on IOP reduction.METHODS: Patients newly diagnosed with manifest primary open-angle glaucoma and included in the Glaucoma Intensive Treatment Study (GITS) were randomized to immediat
Paleogeographic proximity of Baltica and Laurentia in the supercontinent Rodinia has been widely accepted. However, robust paleomagnetic poles are still scarce, hampering quantitative tests of proposed relative positions of the two cratons. A recent paleomagnetic study of the early Neoproterozoic Blekinge-Dalarna dolerite (BDD) dykes in Sweden provided a 946–935 Ma key pole for Baltica, but earlie
Background: Novel efficacious treatments with long-term tolerability are needed for transplant-ineligible, newly diagnosed multiple myeloma (NDMM) patients. This phase 2 study evaluated the safety and efficacy of all-oral ixazomib-cyclophosphamide-dexamethasone (ICd) followed by single-agent ixazomib maintenance. Patients and methods: Patients were randomised (1:1) to receive 4.0 mg of ixazomib, 3
Bicuspid aortic valve (BAV) is the most common congenital cardiac abnormality, occurring in 1% to 2% of the general population. Adults with degenerative aortic valve (AV) disease have been shown to have an elliptical shaped AV annulus. The goal of this study was to investigate the shape of the aortic annulus in children with BAV, coarctation of the aorta (CoA) with or without BAV, and normal contr
Background: Adjuvant chemotherapy (ACT) for breast cancer improves relapse-free survival (BCRFS) and overall survival. Differences in terms of efficacy and toxicity could partly be explained by the significant interpatient variability in pharmacokinetics which cannot be captured by dosing according to body surface area. Consequently, tailored dosing was prospectively evaluated in the PANTHER trial
INTRODUCTION: Differences in treatment and outcome have been reported for persons with haemophilia (PWH) on intermediate-dose (Dutch) and high-dose (Swedish) prophylaxis, but the potential influence of sports participation has not been considered.AIM: To compare sports participation and clinical outcome between adult Dutch and Swedish PWH.METHODS: Self-reported sports participation (type and frequ
Introduction: The potential association between hypo-and hyperthyroid disorders and breast cancer has been investigated in a large number of studies during the last decades without conclusive results. This prospective cohort study investigated prediagnostic levels of thyrotropin (TSH) and triiodothyronine (T3) in relation to breast cancer incidence in pre- and postmenopausal women. Methods: In the
PURPOSE: To compare progressive dynamic, relative quantitative changes in glycans associated with retinal proteins of wild type (wt) and retinal degeneration 1 (rd1) mice during neonatal development and degeneration of retinae. METHODS: Proteins extracted from retinae of postnatal day 2 (PN2), PN7, PN14 wt and rd1 mice were labeled with Cy3-fluorescent dye. Glycome of these proteins was quantified
Purpose: To assess and correlate the levels of inflammatory mediators in the eyes from non-diabetic and diabetic subjects without retinopathy (NDR), with non-proliferative diabetic retinopathy (NPDR) or with proliferative diabetic retinopathy (PDR) to corresponding erum levels. Methods: The levels of interleukin 1β, interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) were analysed by an EL
