Filetype
Aims/hypothesis. Fat accumulation in the liver has been shown to be closely correlated with hepatic insulin resistance and features of insulin resistance, also independently of body weight. It remains to be established how fat in the liver correlates with that in other depots, and whether any association differs between men and women. Methods. Liver fat (assessed using proton spectroscopy), intra-
The R2 protein subunit of class I ribonucleotide reductase (RNR) belongs to a structurally related family of oxygen bridged diiron proteins. In wild-type R2 of Escherichia coli, reductive cleavage of molecular oxygen by the diferrous iron center generates a radical on a nearby tyrosine residue (Tyr122), which is essential for the enzymatic activity of RNR, converting ribonucleotides into deoxyribo
Purpose: Hypoxia in breast cancer is associated with poor prognosis and down-regulation of the estrogen receptor. Carbonic anhydrase IX (CA IX) is a hypoxia-inducible gene that has been associated with poor outcome in many epithelial cancers. Previous studies of CA IX in breast cancer have been carried out on mixed cohorts of premenopausal and postmenopausal patients with locally advanced disease
Data from finished projects may stay in a researcher’s mind for many reasons: a fascination for a field, members’ charm, odd circumstances in the collecting process, analytical frustration etc. Yet the possibility of bringing back one’s attention to these data in order to understand them in new conceptual contexts is rarely as valued as the opposite: a quest for new data to be put in one’s famili
Objective. To study frequency of dose escalation in infliximab-treated patients and to identify possible predictors thereof. Methods. Patients with chronic arthritis initiating their first course of anti-TNF treatment with infliximab at Lund University Hospital were included in a structured clinical follow-up protocol. Information on diagnosis, drug dosage, disease duration, previous and ongoing D
The starting point in this thesis is stroke inflicted individuals’ stories about their experience of stroke, relations in everyday life, and their relations and attempts to return to paid work with the objective of gaining a further understanding of what happens when inflicted by illness and/or disability in working age. Furthermore, it aims at understanding how social relations and ruling relatio
Multiple-quantum spin relaxation is a sensitive probe for correlated conformational exchange dynamics on microsecond to millisecond time scales in biomolecules. We measured differential H-1-N-15 multiple-quantum relaxation rates for the backbone amide groups of the E140Q mutant of the C-terminal domain of calmodulin at three static magnetic field strengths. The differential multiple-quantum relaxa
An easy and rapid hollow-fibre supported liquid membrane method (HFSLM) has been developed to extract and determinate the total concentration of four dinitrophenols in environmental water at ng L-1 level. This extraction method provides a high selectivity, short extraction time and very low cost for real samples. It is a three-phase system, aqueous-organic-aqueous, where the organic solvent is hel
BACKGROUND: Although age is associated with increasing blood pressure, there is a substantial heterogeneity within a certain birth cohort. Whether increase in systolic and diastolic blood pressure is related to pulmonary function is largely unknown. OBJECTIVE: To study blood pressure elevation between 55 and 68 years of age in relation to vital capacity (VC) and forced expiratory volume (FEV1.0) a
Popular Abstract in Swedish Störd magsäcksfunktion är en vanligt förekommande komplikation bland den snabbt tilltagande populationen av diabetiker i världen, också inkluderande andra patient grupper så som de många patienter med diffusa besvär från magen (funktionell dyspepsi). Fördröjd magsäckstömning (gastropares) kan dels leda till en rad obehagliga symtom förknippade med födointaget (tidig mätAbnormal gastric motor function, a frequent complication among the increasing diabetic population of the world, also includes other patient groups such as those many patients with functional dyspepsia. These facts stress the need for a reliable, safe, cost-effective, and simple technique for measuring gastric emptying. To date the ultrasound technique for measuring gastric emptying has been regard
Globaliseringen och den teknologiska utvecklingen som nya möjligheter innebär en teknologi som producerar elektroniskt avfall. Industriländerna producerar, konsumerar och tar del av förtjänsterna för att sedan olagligt transportera avfallet till utvecklingsländer. I samband med dumpning av elektroniskt avfall uppkommer risker vilka vi ämnar att undersöka. För att förstå konsekvenserna av dumpninge
Immigrants, particularly unskilled ones from less developed countries, are identified as one of the most vulnerable groups worldwide. They face various difficulties in order to integrate into their new countries in virtue of cultural differences and inadequate competence and knowledge. An increasing group of them are excluded from the labour market and society which in turn exacerbate their vulner
The European Union aims at being an ethical actor on the global arena and the EU development-policy is directed towards achieving long-term socio-economic development, with a specific focus on Sub-Saharan Africa, where development is showing little progress, and food security and agricultural development is at the top of the agenda. The EU is both the biggest market and the biggest aid-donor for
Patentlagstiftningen är en lagstiftning med syfte att, i det allmännas intresse, främja den industriella utvecklingen. Lagstiftaren anser att patentmöjligheten är av särskild vikt för läkemedelsindustrin då den främjar läkemedelsutvecklingen, en utveckling som även är av intresse för allmänheten. I propositionerna till patentlagen menar lagstiftaren att patentmöjligheten främjar läkemedelsindustriThe Swedish Patent Law is a legislation with the purpose to help the industrial growth to the benefit of society. According to the legislator the Patent Law is particularly important for the pharmaceutical industry since it encourage the development of new medicines, a development that also benefits the society. Therefore, the legislator has, in the proposal to the Patent Law, emphasized the impor
Abstract Failures in achieving the 2010 goals of slowing down or halting the loss of biodiversity, and the setting of new biodiversity targets set for 2020, stress an urgent need to expand current reserve networks and to improve their effectiveness in protecting species and habitats. Habitat suitability models, and derived maps from them, are among the broadest used tools for identifying the ecol
Human Capital is deemed as an imperative factor for economic growth, however, it is argued the extent of this interrelation. Acemoglu, Gallego and Robinson (2014) claim that the institutional framework of a nation, in specificthose of private property are deemed as pivotal for a nation’s development. In this sense, in order to contectualise this argument, the current thesis focuses on the case of
Reindeer husbandry has long been a central element of the traditional livelihood and culture of indigenous Sami people in northern Sweden. However, it faces several challenges from competing land uses, primarily forestry. Different forest conditions are desired by forestry and reindeer husbandry to accommodate each sectors’ distinct interests, promoting high timber and pulp production or improved
Background In the surroundings of the Dadaab Refugee Camps in Kenya lives a large pastoral population under less favourable conditions than the people inside the refugee camps. Many international NGO’s have started to support the hosting community, but there seems to be a lack of long term oriented development work. This project is based on a wonder over why it apparently is difficult for an inter
