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BACKGROUND: Different adiposity traits may be causally related to hypertension in different ways. By using genetic variants as randomly allocated proxies for studying the effect of modifying adiposity traits, the Mendelian randomization approach can be used to investigate this. METHODS AND RESULTS: In this study, we used 4 different genetic risk scores (GRS; GRS-BMI 565, GRS-WHR 324, GRS-VAT 208,
The uptake of diversified farming systems is constrained by a scarcity of evidence regarding financial costs, benefits, and risks. Here, we evaluate the productivity and projected farm income of an agroforestry system, where apples are integrated with arable crops, by combining primary data with ecosystem service and cost-benefit models. Our ecosystem service assessments included: 1) weed and pest
Knowledge remains limited on how the structure of microbial community in paddy soils changes in relation to different types of fertilizers with same amount of nutrients. Thus, here, soil samples were collected at 0–10, 10–20, 20–30, and 30–40 cm depths from a paddy field subjected to four long-term fertilization treatments (no fertilization, mineral fertilization, mineral fertilization combined wi
Pooling metabolomics data across studies is often desirable to increase the statistical power of the analysis. However, this can raise methodological challenges as several preanalytical and analytical factors could introduce differences in measured concentrations and variability between datasets. Specifically, different studies may use variable sample types (e.g., serum versus plasma) collected, t
Wild bees are declining in many parts of the world, which poses a risk for crop pollination and ecosystem health. Land use and climate change are two of the main drivers of the decline, and understanding the interactive effects of these two drivers and wild bees is very important to be able to develop proper responses and mitigate future negative effects. In this thesis I have investigated the ef
The available carbon (C) to phosphorus (P) ratio in soil is regulated by extracellular hydrolases for C and P acquisition by microbes and plants. However, the stoichiometric relationship between acquiring C and P in paddy rhizosphere and bulk soils remains unclear. The objective was to explore the underlying mechanisms of C and P acquisition stoichiometry in rhizosphere and bulk soils in response
The effect of nutrient availability on plant growth and the terrestrial carbon sink under climate change and elevated CO2 remains one of the main uncertainties of the terrestrial carbon cycle. This is partially due to the difficulty of assessing nutrient limitation at large scales over long periods of time. Consistent declines in leaf nitrogen (N) content and leaf δ15N have been used to suggest th
There is an increasing interest in landscape-scale perspectives of ecosystem functioning to inform policy and conservation decisions. However, we need a better understanding of the stability of ecosystem functioning (e.g. plant productivity) at the landscape scale to inform policy around topics such as global food security. We investigate the role of the ecological and environmental context on lan
Background: Obesity is a major public health problem of our time as a risk factor for cardiometabolic disease and the available pharmacological tools needed to tackle the obesity pandemic are insufficient. Neurotensin (NTS) is a 13 amino acid peptide, which is derived from a larger precursor hormone called proneurotensin or Long Form NTS (LF NTS). NTS modulates neuro-transmitter release in the cen
Background: The impact of body mass index (BMI) on mortality varies with age and disease states. The aim of this research study was to analyse the associations between BMI categories and short- and long-term mortality in patients with or without diabetes seeking care at the emergency department (ED) with acute dyspnoea. Population and methods: Patients aged ≥18 years at ED during daytime on weekda
To determine the drivers of phytoplankton biomass, we collected standardized morphometric, physical, and biological data in 230 lakes across the Mediterranean, Continental, and Boreal climatic zones of the European continent. Multilinear regression models tested on this snapshot of mostly eutrophic lakes (median total phosphorus [TP] = 0.06 and total nitrogen [TN] = 0.7 mg L−1), and its subsets (2
BACKGROUND: Corin is a protease expressed in cardiomyocytes that plays a key role in salt handling and intravascular volume homeostasis via activation of natriuretic peptides. It is unknown if Corin loss-of-function (LOF) is causally associated with risk of coronary artery disease (CAD). METHODS: We analyzed all coding CORIN variants in an Italian case-control study of CAD. We functionally tested
Updated information on child feeding practices, nutritional status, and trends related to parental sociodemographic variables is required in developing countries. The objective of this study was to describe infant feeding practices and associated sociodemographic factors among Ethiopian children with an emphasis on complementary feeding (CF). Information on infant feeding and anthropometric measur
This text discusses the professional development of academic developers. It is based on the authors’ reflections and observations in the context of a semi-formal programme, Strategic Academic Development, held for academic developers in different regions of the world. Most recently the programme participants were academic developers in Singapore. In this text, we as authors share what we notice as
Cities are experiencing numerous challenges, adversely affecting human health and wellbeing. Urban green space provides ecosystem services that are important to meet urban challenges. One type of urban green space is private gardens (yards) that make up an essential part of many urban areas. Gardens can support urban biodiversity and provide cultural ecosystem services (CES) to its owner. However,
Scientists have warned decision-makers about the severe consequences of the global environmental crisis since the 1970s. Yet ecological degradation continues and little has been done to address climate change. We investigated early-career conservation researchers' (ECR) perspectives on, and prioritization of, actions furthering sustainability. We conducted a survey (n = 67) and an interactive work
