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Nuclear hormone receptors (NRs) regulate physiology by sensing lipophilic ligands and adapting cellular transcription appropriately. A growing understanding of the impact of circadian clocks on mammalian transcription has sparked interest in the interregulation of transcriptional programs. Mammalian clocks are based on a transcriptional feedback loop featuring the transcriptional activators circad

Using quasi-simultaneous insitu PXRD and XANES, the direct correlation between the oxidation state of Cu ions in the commercially relevant deNOx NH3-SCR zeolite catalyst Cu-CHA and the Cu ion migration in the zeolitic pores was revealed during catalytic activation experiments. A comparison with recent reports further reveals the high sensitivity of the redox-active centers concerning heating rates

In the hippocampus, impaired neurophysiology, compromised neurogenesis, and eventually apoptosis accompany cognitive deficits in insulinopenic (type-1) diabetes (T1D). The underlying pathological mechanisms remain to be defined. The hippocampus has a high density of the cannabinoid type 1 receptor (CB(1)R), which has been shown to control several brain functions affected by diabetes, such as synap

Cysteine is an important amino acid in the redox defense of Mycobacterium tuberculosis, primarily as a building block of mycothiol. Genetic studies have implicated de novo cysteine biosynthesis in pathogen survival in infected macrophages, in particular for persistent M. tuberculosis. Here, we report on the identification and characterization of potent inhibitors of CysM, a critical enzyme in cyst

This collection of essays explores the remarkable range and cultural significance of the engagement with 'infancy' during the Romantic period. Taking its point of departure in the commonplace claim that the Romantics invented childhood, the book traces that engagement across national boundaries, in the visual arts, in works of educational theory and natural philosophy, and in both fiction and non-

From a nanoscience perspective, cellular processes and their reduced in vitro imitations provide extraordinary examples for highly robust few or single molecule reaction pathways. A prime example are biochemical reactions involving DNA molecules, and the coupling of these reactions to the physical conformations of DNA. In this review, we summarise recent results on the following phenomena: We inve

It has been proposed that the local segregation of kinases and the tyrosine phosphatase CD45 underpins T cell antigen receptor (TCR) triggering, but how such segregation occurs and whether it can initiate signaling is unclear. Using structural and biophysical analysis, we show that the extracellular region of CD45 is rigid and extends beyond the distance spanned by TCR-ligand complexes, implying t

Denna rapport analyserar kommunala brukarråd rörande missbruks- ochberoendevård, äldreomsorg samt frågor kring psykiska och fysiskafunktionshinder. Rapporten utgår från en enkätundersökning av brukarråd i allaSkånes kommuner. Tjänstemän med ansvar för de kommunala brukarråden ficksvara på frågor om förekomst av brukarråd, vilka organisationer som medverkar ide olika kommunala brukarråden, vilka er

In the aggregate industry the use of geophysical measuring is rare. The aim of this project is to investigate how geophysical instruments can be a tool in prospecting for rock quarries, and also how they can be a help in which direction they should expand in. To have control over the quality of the aggregates is important and therefore to know when the rock mass is changing is of interest for the

Several studies have proposed aerobic methane (CH4) emissions by plants. If confirmed, these findings would further increase the imbalance in the global CH4 budget which today underestimates CH4 sinks. Oxidation by OH-radicals in the troposphere is the major identified sink followed by smaller contribution from stratospheric loss and oxidation by methano- and methylotrophic bacteria in soils. This