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For many years, a connection between circadian clocks and cancer has been postulated. Here we describe an unexpected function for the circadian repressor CRY2 as a component of an FBXL3-containing E3 ligase that recruits T58-phosphorylated c-MYC for ubiquitylation. c-MYC is a critical regulator of cell proliferation; T58 is central in a phosphodegron long recognized as a hotspot for mutation in ca
The article is a result of field studies on the transformations of multicultural heritage in the east-central European cities of Cracow, Wrocław, Lviv and Chernivtsi. In all these cities, a majority of the pre-war populations (and in Wrocław, practically all pre-war residents) disappeared as a result of WWII. After decades of silence imposed by the ruling communist elites, collective memories of t
Methane is a powerful greenhouse gas and growing concern regarding global climate changes over the last years has pointed out the need to quantify and control the leaking of methane into the atmosphere. Landfill gas is regarded as one of the major sources for methane migration to the atmosphere. In this study we present research work with the objective to evaluate the use of geoelectrical resistiv
The research history and conditions in experimental archaeology up until today show a heavy emphasis on technological studies within a hypothetical-deductive theoretical paradigm. How is it possible to enhance the conditions for experimental archaeology so that it can also develop as a humanistic area of research, more closely related to existential perspectives of human life? We argue for the int
Desiccation of the Sahara since the middle Holocene has eradicated all but a few natural archives recording its transition from a "green Sahara" to the present hyperarid desert. Our continuous 6000- year paleoenvironmental reconstruction from northern Chad shows progressive drying of the regional terrestrial ecosystem in response to weakening insolation forcing of the African monsoon and abrupt hy
Hexokinase 2 (Hxk2p) from Saccharomyces cerevisiae is a bi-functional enzyme being both a catalyst and an important regulator in the glucose repression signal. In the presence of xylose Hxk2p is irreversibly inactivated through an autophosphorylation mechanism, affecting all functions. Consequently, the regulation of genes involved in sugar transport and fermentative metabolism is impaired. The ai
In recent years a new generation of tracking particle detectors has been developed for particle physics experiments. One such detector, the microstrip gas counter (MSGC) is similar to the multiwire proportional chamber but consists of fine strips of metal on a substrate rather than suspended wires. The main feature of this device is the sub-millimetre readout spacing. When filled with tissue-equiv
To investigate the feasibility of transplanting human neural progenitor cells (hNPCs) to the retina of nonimmunosuppressed pigs, cultured hNPCs were injected into the subretinal space of 5 adult pigs after laser burns were applied to promote donor cell integration. Postoperatively, the retinal vessels appeared normal without signs of exudation, bleeding, or subretinal elevation. Eyes were harveste
The St Louis aerosol was sampled during the period 16-22 August 1973 simultaneously at two locations using cascade impactors for sequential 12-hour samples. The six particle size fractions of each sampling were individually analyzed using PIXE for elements from S to Br and beyond and for heavy elements including Pb which permitted time variations of concentrations and particle size distributions t
Bra inomhusklimat och effektiv energianvändning är av yttersta vikt när nya hus ska byggas. Ny teknik har fått ner behovet av energi för uppvärming till ungefär hälften sedan 70-talet. Men elförbrukningen har ökat kraftigt. Här presenterar författarna en systematisk helhetssyn att både spara energi och åstadkomma ett behagligt inneklimat när nya hus utformas eller gamla renoveras. Byggteknik och
The gamma-brass related phase CrZn17+delta(-0.75 <= delta <= 2.00) in the Cr-Zn binary system has been synthesized and the structure has been analyzed by powder and single crystal X-ray diffraction. The compound crystallizes in the cubic space group F (4) over bar 3m (216). The unit cell contains 400-403 atoms. The phase width arises due to a disorder phenomenon. The structure can be described as
