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Popular Abstract in Swedish Den organiska kemin har spelat en viktig roll i samhällsutvecklingen. Förmågan att på ett kontrollerat sätt kunna syntetisera substanser är en nyckelkunskap för vetenskap och industri. Utvecklingen har idag kommit så långt att man även för kommersiellt bruk kan syntetisera mycket avancerade molekyler som t. ex. läkemedel. På senare år har den organiska syntesen fått en A route from epoxy alcohols to cis- and trans-trisubstituted vinylaziridines has been developed. The vinylaziridines have been used as substrates in the base induced aza-[2,3]-Wittig rearrangement to substituted 1,2,3,6-tetrahydropyridines. The influence of the anion-stabilising group on the reaction outcome has been investigated and it was found that tert-butyl ester enolate promotes a clean conv

OBJECTIVE: To examine the expression pattern of some novel matrix metalloproteinases (MMPs) in cycling endometrium. DESIGN: Experimental study. SETTING: Department of Obstetrics and Gynecology of the Palacky University Medical School and University Hospital, Olomouc, Czech Republic, Department of Obstetrics and Gynecology, University Hospital, Lund, Sweden. METHODS: We studied MMP-12, -16, -17, -1

BACKGROUND: Glibenclamide (Gb) may provoke long-lasting hypoglycaemic reactions, and one of the known risk factors is impaired renal function. We have demonstrated Gb to have a terminal elimination half-life of 15 h, and the main metabolites have a hypoglycaemic effect. With few exceptions, detailed studies on second generation sulphonylureas in diabetics with impaired renal function are lacking.

AIMS/HYPOTHESIS: Type 1 diabetes in children is characterised by autoimmune destruction of pancreatic beta cells and the presence of certain risk genotypes. In adults the same situation is often referred to as latent autoimmune diabetes in adults (LADA). We tested whether genetic markers associated with type 1 or type 2 diabetes could help to discriminate between autoimmune and non-autoimmune diab

Aim: Less invasive surfactant administration (LISA), namely surfactant instillation through a thin catheter in the trachea during spontaneous breathing, is increasingly used for premature infants. We surveyed the use of this technique in the Nordic countries in autumn 2015. Methods: A link to a web-based survey of surfactant administration methods was emailed to the directors of all neonatal units

A joint analysis of five paternal half-sib Holstein families that were part of two different granddaughter designs (ADR- or Inra-design) was carried out for five milk production traits and somatic cell score in order to conduct a QTL confirmation study and to increase the experimental power. Data were exchanged in a coded and standardised form. The combined data set (JOINT-design) consisted of on

This article contributes to the emerging literature on possibilities to disseminate agonistic narratives in seemingly deadlocked conflict settings. In this context, conflict parties’ existence is often perceived as being under threat, which makes it demanding to question the current societal order. However, even in the most protracted of conflicts, narratives exist that challenge concurring undersThis article contributes to the emerging literature on possibilities to disseminate agonistic narratives in seemingly deadlocked conflict settings. In this context, conflict parties’ existence is often perceived as being under threat, which makes it demanding to question the current societal order. However, even in the most protracted of conflicts, narratives exist that challenge concurring unders

Bias-based bullying (i.e., bullying due to marginalized identities) is a significant and ongoing challenge within contemporaryeducational settings. Teachers are crucial in mitigating such harmful behaviors and cultivating positive peer relationships. Thepresent study explores teachers’ perceptions of and intervention intentions in bias-based bullying situations across diversecultural and educationBias-based bullying (i.e., bullying due to marginalized identities) is a significant and ongoing challenge within contemporary educational settings. Teachers are crucial in mitigating such harmful behaviors and cultivating positive peer relationships. The present study explores teachers’ perceptions of and intervention intentions in bias-based bullying situations across diverse cultural and educat

Purpose: Tau pathology is associated with concurrent atrophy and decreased cerebral blood flow (CBF) in Alzheimer’s disease (AD), but less is known about their temporal relationships. Our aim was therefore to investigate the association of concurrent and longitudinal tau PET with longitudinal changes in atrophy and relative CBF. Methods: We included 61 individuals from the Amsterdam Dementia Cohor

In this paper, design and measurements of a fully integrated power amplifier (PA) are presented. The PA consists of two amplifying chains each having a driver and a power stage. A low loss on chip power combiner combines the outputs from two amplifying chains, and also performs impedance transformation and differential to single-ended conversion. To linearize the PA, the driver stage is biased in

This paper examines the connection between inflation and long-term economic growth in the European Union by using a panel data analysis over the period 1983-2023. The study is built on earlier research which indicates that inflation may have a negative impact on economic growth but especially at higher levels. Relying on both exogenous and endogenous growth theories, this study also highlights the

Background: It is recommended that patch-test readings include a day (D)7 reading. Substitution of the D7 reading with a photo may be a valid option. Objectives: To compare the sensitivity of digital photos at D7 to clinical readings, to assess the number of positive reactions appearing at D7 only (late reactions), and after D7 only (delayed reactions). Methods: Patients patch tested in six Europe

Title: Proletarian polyphony - Western harmony in Chinese music from the first half of the 20th century The aim of this essay is to examine the use of harmony and polyphony in Chinese music from the first half of the 20th century. Traditional Chinese music contains no chords and no polyphony. At the turn of the 20th century China showed an increasing interest in European culture and music. Many C

We observe that, while predicting returns remain difficult and uncertain, volatility exhibit more persistence and predictability due to well-known patterns such as volatility clustering (Mandelbrot, 1967). We test whether short-horizon volatility forecasts can be used to time leverage in a passive index strategy so as to mitigate the growth penalty from volatility drag in leveraged exchange-traded

Background: The global plant-based food shift puts high pressure on manufacturing capacity at facilities like Oatly's Landskrona site. This environment faces high combinatorial complexity due to growing product variety and sequence-dependent cleaning requirements. Relying on manual, experience-based planning to navigate these rules limits throughput and introduces organisational risk. Purpose

Background: MR-generated acoustic noise may be particularly concerning at 7-Tesla (T) systems. Noise levels can be reduced by altering gradient output using software optimization. However, such alterations might influence image quality or prolong scan times, and these optimizations have not been well characterized. Purpose: To evaluate image quality, sound pressure levels (SPLs), and perceived noi

Background: Eating disorders significantly impact physical health and have negative psychosocial consequences. The global burden of anorexia nervosa and bulimia nervosa among young females is estimated to account for 1.9 million disability-adjusted life years. Early identification of disordered eating attitudes is critical for preventing the progression to more severe forms of eating disorders; ho