Filetype
This chapter explores performances of emotion regulation through a dramaturgical lens, focusing on occupations with high performative demands. While reviewing research and theorizing on performance, we point to key intersections between sociological studies on emotion management and psychological studies on emotion regulation. First, we focus on the scaffolding of performance, how the script and t
Background and aimMany patients with depressive disorders do not improve with first-line treatment with selective serotonin inhibitors (SSRIs). Adverse drug reactions (ADRs) are common. However, there are no reliable methods to predict treatment response.The general aim of this thesis was to investigate the role of peripheral serotonin and the polymorphic CYP2D6 gene as potential biomarkers of tre
Aims: To examine the separate associations of glycemic control and chronic kidney disease with hospitalization days over one year in patients with type 2 diabetes (T2D). Materials and methods: A cross-sectional study using retrospective data on T2D patients in Region Halland, Sweden, during 2020. Data from the Region Halland database included hospitalizations, emergency visits, primary care encoun
Background There is a lack of contemporary data describing patients with left ventricular (LV) systolic dysfunction post myocardial infarction (MI) in terms of symptom burden and secondary prevention measures. The aim of this study was to describe patients with various degrees of LV systolic dysfunction after a first MI, their symptom burden, quality of life and adherence to recommended secondary
Aims: Drug–gene interactions (DGIs) modify drug response and safety, yet their influence on diabetic microvascular complications remains unclear. This study aimed to elucidate the role of DGIs in these complications. Materials and Methods: Using UK Biobank (UKB) data, we identified medications frequently prescribed to individuals with diabetes and defined DGIs based on the Food and Drug Administra
Introduction: Suturing is a fundamental component of surgical procedures, wherein training emphasises the significance of gentle tissue handling. The suturing process involves the pressure exerted by the forceps onto the tissue, as well as the medial traction force applied to stabilise the tissue during the needle bite. This study examined the forces involved in tissue handling during suturing, co
Background: Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) are frequently comorbid and are individually associated with increased risk of suicidal behavior. However, whether their comorbidity exacerbates this risk has not been adequately investigated. Methods: Using a Swedish birth cohort (born 1970–1990; N = 799,203–858,983), we employed Aalen’s linear hazards models to evalu
Background: Programmed death-ligand 1 (PD-L1) immunocytochemical (ICC) analysis of cell blocks (CBs) has recently emerged in clinical practice. Unlike standardized immunohistochemistry on formalin-fixed, paraffin-embedded tissues, cytology involves various preparation methods and fixatives. This study investigated how various fixatives influence PD-L1 immunoreactivity in CBs from malignant pleural
GOALS: To assess the incidence, type, and severity of infections in patients with IBD before and after starting thiopurine therapy.BACKGROUND: Thiopurines have been used for decades in the treatment of inflammatory bowel disease (IBD), yet real-world data regarding the extent and types of infections associated with their use are scarce.STUDY: We included all thiopurine-naive adults with IBD who in
Background: We aimed to assess the risk of serious infections in patients with inflammatory bowel disease (IBD) exposed to different advanced therapies. Methods: We linked nationwide registers and compared rates of incident serious infections in patients with Crohn’s disease (CD) and ulcerative colitis (UC) exposed to medical therapies versus matched general population comparators during 2007-2023
Introduction: Using time-limited trials of low-dose, sustained-release morphine to reduce chronic breathlessness to evaluate net effects may generate opioid withdrawal symptoms if medication is ceased. This sub-study of a larger randomized, placebo-controlled, double-blind trial aimed to evaluate if this occurred. Methods: People with modified Medical Research Council breathlessness scores of 3 or
BackgroundThe Job Demand–Control–Support (JD-C-S) model evaluates how psychosocial work factors affect health and performance. We examined how demographics, job title, and experience influence demand, control, and support among Ghanaian pharmacy staff.MethodsA cross-sectional survey of pharmacy personnel from Tamale and Sagnerigu was conducted using the JD-C-S questionnaire. Demand and control ite
Introduction Systemic inflammation is postulated to mediate heat stroke and heat-related organ injury, yet acute inflammatory responses among heat-stressed workers remains poorly understood. We aimed to describe neutrophil mobilisation and potential release of DNA during heat stress in multiple hot occupational settings and a controlled experimental setting. Methods Neutrophil:lymphocyte ratio (NL
Aims: Sorbitol and myo-inositol levels and morphology of sural nerve were compared with nerve function and clinical neuropathy in men with diabetic, impaired (IGT), and normal glucose tolerance. Methods: After neurography of sural nerve and determinations of sensory thresholds for vibration, warm and cold on the foot, whole nerve sural nerve biopsy was performed in 10 men with Type 1 diabetes mell
1. In the present study, the vasodilator actions of methanandamide and capsaicin in the rat isolated mesenteric arterial bed and small mesenteric arterial segments were investigated. 2. Methanandamide elicited concentration-dependent relaxations of preconstricted mesenteric arterial beds (pEC 50 = 6.0 ± 0.1, E(max) = 87 ± 3%) and arterial segments (pEC 50 = 6.4 ± 0.1, E(max) = 93 ± 3%). 3. In art
Background: To determine the association between time from injury to ACL reconstruction (TimeInjury-ACLR) and biochemical markers of cartilage metabolism and inflammation six months following ACL reconstruction (ACLR). Methods: Individuals with a unilateral ACL injury were enrolled at initial presentation in the orthopedic clinic; blood was collected six months following ACLR. Enzyme-linked immuno
OBJECTIVES: To assess whether sevoflurane provides better haemodynamic stability than propofol in acute right ventricular (RV) ischaemia-reperfusion. METHODS: Open-chest pigs (mean ± standard deviation, 68.8 ± 4.2 kg) anaesthetized with sevoflurane (n = 6) or propofol (n = 6) underwent 60 min of RV free wall ischaemia and 150 min of reperfusion. Haemodynamic parameters and blood flow in the 3 majo
BACKGROUND: A calcineurin inhibitor (CNI)-free immunosuppressive regimen has been demonstrated to improve renal function early after heart transplantation, but long-term outcome of such a strategy has not been well described. METHODS: In the randomized SCHEDULE trial, de novo heart transplant recipients received (1) everolimus with reduced-exposure CNI (cyclosporine) followed by CNI withdrawal at
Published meta-analyses indicate significant but inconsistent incident type-2 diabetes(T2D)-dietary glycemic index (GI) and glycemic load (GL) risk ratios or risk relations (RR). It is nowover a decade ago that a published meta-analysis used a predefined standard to identify validstudies. Considering valid studies only, and using random effects dose-response meta-analysis(DRM) while withdrawing sp
OBJECTIVE: To discover common genetic variants associated with poststroke outcomes using a genome-wide association (GWA) study. METHODS: The study comprised 6,165 patients with ischemic stroke from 12 studies in Europe, the United States, and Australia included in the GISCOME (Genetics of Ischaemic Stroke Functional Outcome) network. The primary outcome was modified Rankin Scale score after 60 to
