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Disruption of intracellular calcium homeostasis is thought to play a role in neurodegenerative disorders such as Huntington's disease (HD). To study different aspects of putative pathogenic mechanisms in HD, we aimed to establish an in vitro model of calcium-induced toxicity in striatal neurons. The calcium ionophore A23187 induced a concentration- and time-dependent cell death in cultures of embr

There is a well-documented large positive correlation between education and health and yet it remains unclear as to whether this is a causal relationship. Potential reasons for this lack of clarity include estimation using different methods, analysis of different populations and school reforms that are different in design. In this paper we assess whether the type of school reform, the instrument a

Objective: The decline in suicide rates has leveled off in many countries during the last decade, suggesting that new interventions are needed in the work with suicide prevention. Learnings from investigations of suicide should contribute to the development of these new interventions. However, reviews of investigations have indicated that few new lessons have been learned. To be an effective tool,

Flicker can be annoying, but above all it can have a negative effect on human health; causing irritation, headaches, eye strain and migraines. With the introduction of LED lamps, flicker has once again become a problem. In addition to the unnecessary suffering caused to individuals, the negative consequences create an obstacle to the wide and rapid adoption of new LED technology and thus also an oFlicker can be annoying, but above all it can have a negative effect on human health; causing irritation, headaches, eye strain and migraines. With the introduction of LED lamps, flicker has once again become a problem. In addition to the unnecessary suffering caused to individuals, the negative consequences create an obstacle to the wide and rapid adoption of new LED technology and thus also an o

A number of deleterious health effects have been identified from exposure to outdoor air-borne particulate matter. This issue is complicated by the fact that people are spending most of the time indoors, where particles of both indoor and outdoor origin are present. The aim of this work was to assess the differences in particle chemical composition inside and outside of the residence and gain bett

BackgroundThe literature on the relationship between anxiety and suicidal behaviors is limited and findings are mixed. This study sought to determine whether physicians noted anxiety symptoms and suicidality in their patients in the weeks and months before suicide.MethodsData were derived from a nationwide medical record review of confirmed suicides in Sweden in 2015. Individuals with at least one

BACKGROUND: Exertional breathlessness is a major symptom in cardiorespiratory disease and is often assessed using the modified Medical Research Council (mMRC) questionnaire. The mMRC might underestimate exertional breathlessness in people with impaired exercise capacity who have reduced their physical activity to avoid the symptom. We aimed to evaluate the ability of mMRC to detect abnormally high

Deaths of despair (DoD), encompassing suicide, drug overdose, and alcohol-related mortality, are often linked to social and psychological distress. This study examined the long-term risk of DoD among individuals previously hospitalized for suicide attempts, with a focus on substance use problems and psychiatric disorders as potential risk factors. A prospective cohort of 1044 individuals admitted

Background: Access to contraception can be a transformational intervention towards advancement of education, health, and freedom of choice. Countries have committed to improving access to contraception enshrined in the sustainable development goals (SDGs), indicator 3.7.1. Our study seeks to investigate the level of inequality in current use of modern contraception and unmet need for contraception

Syfte: Syftet med studien är att undersöka effekten av ett kartläggningsbesök med efterföljande telefonuppföljning på användande av kommunikationsstrategier och hörselrelaterad livskvalitet för individer med betydande hörselnedsättning (TMV4 60-69 dB HL på bättre örat). Metod: Ett kartläggningsbesök utformades där fokus låg på individen och dennes upplevda besvär kring den egna hörselnedsättningen

Popular Abstract in Swedish Blodbildande stamceller förekommer i mänsklig benmärg i en frekvens på ca 1/100 000 celler. Med hjälp av cellytemarkörer, t.ex. CD34, kan man rena fram cellpopulationer som är anrikade på stamceller, men det saknas exakt kunskap om hur enskilda stamceller ser ut. De blodbildande stamcellerna har förmåga att vid celldelning antingen förnya sig själva eller att mogna ut. Hematopoietic stem cells (HSCs) have the capacity to maintain hematopoiesis throughout life. HSCs are ideal targets for permanent gene transfer, as the transgene will be expressed in all the progeny of the gene-modified stem cells. The aim of this thesis was to optimize conditions for retroviral gene transfer to human candidate HSCs and to study mechanisms interfering with efficient gene transfer.

Background: In most resource poor countries, particularly sub-Saharan Africa, modern contraceptive use and prevalence is unusually low and fertility is very high resulting in rapid population growth and high maternal mortality and morbidity. Current evidence shows slow progress in expanding the use of contraceptives by women of low socioeconomic status and insufficient financial commitment to fami

Syftet med HörNet var att undersöka om vi med hjälp av en strukturerad, individuell internetutbildning kunde minska hörselskadades handikappupplevelse. Vidare ville vi undersöka om internetutbildningen ledde till forbättrad hörapparatnytta, om deltagarna upplevde minskad oro och nedstämdhet samt om de var mer nöjda med sina hörapparater efter utbildningen. Utbildningen bestod av fem veckornoduler

De senaste 15-20 åren har övervikt och fetma blivit ett växande folkhälsoproblem i västvärlden. Befolkningen har en allt mer stillasittande fritid och en tredjedel uppfyller inte den föreslagna rekommendationen om 30 minuters fysisk aktivitet om dagen. Användning av stegräknare kan vara ett sätt att motivera och inspirera till ökad fysisk aktivitet. På ett stort processföretag med dag- och skift a

Syftet med uppsatsen är att fastställa utifrån ett konsultperspektiv vilka kritiska framgångsfaktorer som konsultbolagen har möjlighet att påverka vid en implementering av ett affärssystem. Valet att se KFF ur ett konsultperspektiv baserar sig på en saknad av forskning inom området på det vis att tidigare gjorda studier inte riktat sig mot denna grupp. Genom intervjuer med representanter från kons