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The present work is mainly focused on the development of enzyme-based bioanalytical devices, which can further be applied as analytical tools for industrial, medical and environmental applications. The first part of the work deals with the practical applications of thermometric biosensors for determination of various sugars (fructose and lactose) in a real samples. Thermometric biosensors possess

Inflammation is a well-established risk factor for the development of coronary artery disease (CAD) and acute coronary syndrome (ACS). However, less is known about its influence on the outcome of ACS. The aim of this study was to determine if blood biomarkers of inflammation were associated specifically with acute myocardial infarction (MI) or unstable angina (UA) in patients with ACS.

ABSTRACT: BACKGROUND: Hip dislocation after arthroplasty for femoral neck fractures remains a serious complication. The aim of our study was to investigate the dislocation rate in acute femoral neck fracture patients operated with a posterior approach with cemented conventional or dual articulation acetabular components. METHODS: We compared the dislocation rate in 56 consecutive patients operated

Abstract Data from arthroplasty registers are often analyzed using survival methods. Several methodological problems exist, for example relating to competing events, non-random censoring, non-proportional hazards and dependent observations. League tables and ranking of specific survival results leds to further methodological difficulties. Most of these problems are, however, well known and a numbe

BACKGROUND: The genes caspase-8 (CASP8) and caspase-10 (CASP10) functionally cooperate and play a key role in the initiation of apoptosis. Suppression of apoptosis is one of the major mechanisms underlying the origin and progression of cancer. Previous case-control studies have indicated that the polymorphisms CASP8 D302H and CASP10 V410I are associated with a reduced risk of breast cancer in the

OBJECTIVES: Meniscal pathology in which the aetiology is often unclear is a frequent finding on knee MRI. This study investigates potential risk factors for medial meniscal lesions or extrusion in middle-aged and elderly persons. METHODS: Prospective cohort study using population-based subjects from Birmingham, Alabama and Iowa City, Iowa, USA (the Multicenter Osteoarthritis Study). 644 men and

OBJECTIVES: /st> To investigate the association between meniscal pathology and incident or enlarging bone marrow lesions (BML) in knee osteoarthritis. METHODS: /st> The authors studied subjects from the Multicenter Osteoarthritis Study aged 50-79 years either with knee osteoarthritis or at high risk of the disease. Baseline and 30-months magnetic resonance images of knees (n=1344) were scored for

Supersolidity—a coexistence of superfluidity and crystalline or amorphous density variations—has been vividly debated ever since its conjecture. While the initial focus was on helium-4, recent experiments uncovered supersolidity in ultracold dipolar quantum gases. Here we propose a self-bound supersolid phase in a binary mixture of Bose gases with short-range interactions, making use of the nontri

After demonstration of a 23% power conversion efficiency, a high operational stability is the next most important scientific and technological challenge in perovskite solar cells (PSCs). A potential failure mechanism is tied to a bias-induced ion migration, which causes current–voltage hysteresis and a decay in the device performance over time. Herein, alkali salts are shown to mitigate hysteresis

The present work has been carried out with the aim to design and develop an efficient light harvesting inorganic-organic hybrid nanoscale material by employing a less toxic, environment friendly inorganic substance and also to understand the mechanism of inter-particle electronic interaction between the inorganic and organic components of the nanomaterial. Specifically, the inorganic-organic hybri

A human molecular chaperone protein, DnaJ heat shock protein family (Hsp40) member B6 (DNAJB6), efficiently inhibits amyloid aggregation. This inhibition depends on a unique motif with conserved serine and threonine (S/T) residues that have a high capacity for hydrogen bonding. Global analysis of kinetics data has previously shown that DNAJB6 especially inhibits the primary nucleation pathways. Th

Organic solar cells (OSCs) consisting of an ultralow-bandgap nonfullerene acceptor (NFA) with an optical absorption edge that extends to the near-infrared (NIR) region are of vital interest to semitransparent and tandem devices. However, huge energy-loss related to inefficient charge dissociation hinders their further development. The critical issues of charge separation as exemplified in NIR-NFA

Air pollution is estimated to cause more than 7000 deaths annually in Sweden alone. To reduce the impact of air pollution and to plan and build sustainable cities, it is vital that research is translated into efficient decisions and practice. However, how do civil servants in a municipality access research results? How do they normally find relevant information, and what obstacles are there to acc