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Aresenic trioxide (ATO) is proven to be active against leukaemia cells by inducing apoptosis and differentiation. Even though ATO could effectively induce remissions of leukaemia cells, the drug resistance was observed occasionally. To further dissect the mechanism of ATO resistance, we selected the ATO-resistant SH-SY5Y cells and found that Bcl-2 controlled the sensitivity of ATO in SH-SY5Y cells
The ability to grow defect-free nanowires in lattice-mismatched material systems and to design their properties has made them ideal candidates for applications in fields as diverse as nanophotonics, nanoelectronics and medicine. After studying nanostructures consisting of elemental and binary compound semiconductors, scientists turned their attention to more complex systems - ternary nanowires. Co
Conversion of temperature gradients to charge currents in quantum dot systems enables probing various concepts from highly efficient energy harvesting and fundamental thermodynamics to spectroscopic possibilities complementary to conventional bias device characterization. In this work, we present a proof-of-concept study of a device architecture where bottom-gates are capacitively coupled to an In
We report Coulomb blockade transport studies of semiconducting InAs nanowires grown with epitaxial superconducting Al and ferromagnetic insulator EuS on overlapping facets. Comparing experiment to a theoretical model, we associate cotunneling features in even-odd bias spectra with spin-polarized Andreev levels. Results are consistent with zero-field spin splitting exceeding the induced superconduc
Demonstration of Majorana non-Abelian properties is a major challenge in the field of topological superconductivity. In this work, we propose a minimal device and protocol for testing non-Abelian properties using charge-transfer operations between a quantum dot and two Majorana bound states combined with reading the parity state using a second dot. We use an adiabatic perturbation theory to find f
Organisations that deviate from ethical expectations regarding their behaviour risk damaging their image and, hence, threatening their very survival (refs.). Contemporary representations of fashion retail in media and popular culture—which depict fashion retail as a key contributor to the climate crisis—are, therefore, a challenge for retailers in general and for fashion retailers in particular. I
BACKGROUND: Breathlessness is a multidimensional symptom prevalent in elderly affecting many aspects of life. We aimed to determine how different dimensions of breathlessness are associated with physical and mental quality of life (QoL) in elderly men.METHODS: This was a cross-sectional, population-based analysis of 672 men aged 73 years in a Swedish county. Breathlessness was assessed using Dyspn
PURPOSE OF REVIEW: Assessment of underlying conditions that contribute to breathlessness is fundamental for symptom management. This review aims to summarize the knowledge from the past two years on the most common underlying conditions among individuals with breathlessness in the general population and to identify research gaps. RECENT FINDINGS: Nine studies from the last two years were included
Objectives: To investigate early and long-term outcomes after treatment of carotid artery stenosis in patients with type 2 diabetes (T2D) compared to patients without T2D. Design/method: This observational nationwide population-based retrospective cohort study investigated all T2D patients treated for carotid stenosis registered in the National Swedish Vascular Surgery and the National Diabetes Re
As the most common type of defects in WO3, surface oxygen deficiencies have been widely investigated in terms of their structure as well as physicochemical properties. In general, oxygen vacancy on the surface may lead to the reconstruction of the surface structure due to the need for surface energy minimization, especially for the area with high oxygen vacancy concentration. However, such a pheno
Long-term stability is one of the major challenges for p-i-n type perovskite solar modules (PSMs). Here, we demonstrate the fabrication of fully laser-patterned series interconnected p-i-n perovskite mini-modules, in which either single Cu or Ag layers are compared with Cu/Au metalbilayer top electrodes. According to the scanning electron microscopy measurements, we found that Cu or Ag top electro
Active pre-chamber configurations are considered a valuable solution for improving the operation of the internal combustion engine, in the view to overcome the many challenges it has been made to face. Combining this technology with the use of natural gas, a fuel that has increasing availability and interest in the market share, it is possible to burn ultra-lean mixtures (with air-to-fuel ratios,
Particulate radioactivity, a characteristic of particulate matter, is primarily determined by the abundance of radionuclides that are bound to airborne particulates. Exposure to high levels of particulate radioactivity has been associated with negative health outcomes. However, there are currently no spatially and temporally resolved particulate radioactivity data for exposure assessment purposes.
Flies keep track of a food site by path integration. A novel behavioral paradigm has been combined with computational models to show that Drosophila can track at least three food patches simultaneously by using the center of gravity of all food sites as the reference point for their path integrator.
Vertical III-V heterostructure MOSFETs exhibit outstanding performance at reduced supply voltages. In this paper, we report on a novel process of extending high-speed device operation towards higher voltages. The device vertical geometry allows for engineering a field plate by covering the nanowire drain area with a 10-nm-thick SiO2 film. The film acts as a field moderator in the device drain regi
Background Alcohol use disorder (AUD) is clinically heterogeneous. We examine its potential genetic heterogeneity as a function of sex, age, clinical features and mode of ascertainment. Methods In the Swedish population born 1932-1995 (n = 5 829 952), we examined the genetic risk profiles for AUD, major depression (MD), anxiety disorders, bipolar disorder, drug use disorder (DUD), attention defici
BACKGROUND: Patient-reported outcome measures (PROMs) are validated questionnaires that are completed by patients. Arthroplasty registries vary in PROM collection and use. Current information about registry collection and use of PROMs is important to help improve methods of PROM data analysis, reporting, comparison, and use toward improving clinical practice. QUESTIONS/PURPOSES: To characterize PR
Controlled generation and detection of quantum entanglement between spatially separated particles constitute an essential prerequisite both for testing the foundations of quantum mechanics and for realizing future quantum technologies. Splitting of Cooper pairs from a superconductor provides entangled electrons at separate locations. However, experimentally accessing the individual split Cooper pa
Natural sounds, and bird song in particular, play a key role in building and maintaining our connection with nature, but widespread declines in bird populations mean that the acoustic properties of natural soundscapes may be changing. Using data-driven reconstructions of soundscapes in lieu of historical recordings, here we quantify changes in soundscape characteristics at more than 200,000 sites
