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Sweden surpasses the UNAIDS 95-95-95 target : estimating HIV-1 incidence, 2003 to 2022

BackgroundSweden reached the UNAIDS 90-90-90 target in 2015. It is important to reassess the HIV epidemiological situation due to ever-changing migration patterns, the roll-out of PrEP and the impact of the COVID-19 pandemic.AimWe aimed to assess the progress towards the UNAIDS 95-95-95 targets in Sweden by estimating the proportion of undiagnosed people with HIV (PWHIV) and HIV incidence trends.M

Virtual reality-assisted assessment of paranoid ideation in forensic psychiatric inpatients : A mixed-methods pilot study

Background: Reliable and valid assessment of paranoia is important in forensic psychiatry for providing adequate care. VR technology may add to current assessment procedures, as it enables observation within realistic (social) situations resembling the complexity of everyday life. VR constitutes a promising tool within forensics, due to the restricted nature of forensic psychiatric hospitals and e

Identification of JAZF1, KNOP1, and PLEKHA1 as causally associated genes and drug targets for Alzheimer's disease : a summary data-based Mendelian randomization study

BACKGROUND: There is a growing body of evidence indicating the significant role of the immune system and immune cells in the progression of Alzheimer's disease (AD). However, the exact role of genes from various immune cell types in AD remains unclear. We aimed to utilize summary data-based Mendelian randomization (SMR) to explore the potential causal relationships between genes in specific immune

Preterm or early term birth and risk of attention-deficit/hyperactivity disorder : a national cohort and co-sibling study

Purpose: To examine risks of attention-deficit/hyperactivity disorder (ADHD) in preterm and early term birth survivors, and potential sex-specific differences. Methods: A national cohort study was conducted of all 4061,795 singletons born in Sweden in 1973–2013 who survived infancy, followed up for ADHD identified from nationwide diagnoses and medications through 2018. Poisson regression was used

Addressing the Healthcare Needs of African Men who have Sex with Men: Barriers to Healthcare and Promoting HIV and STI Treatment in Sub-Saharan Africa.

Barriers to healthcare for men who have sex with men (MSM) in sub-Saharan Africa (SSA) are rooted in stigma and discrimination against MSM fuelled by the criminalization of homosexuality. These barriers are influenced by factors involving MSM and the healthcare workers (HCWs). MSM are uncomfortable disclosing their identities and conceal symptoms of sexually transmitted infections (STIs), especial

Provision of professional interpreters and Heart School attendance for foreign-born compared with native-born myocardial infarction patients in Sweden

Objective: Interactive patient education, referred to as Heart School (HS), is an important part of cardiac rehabilitation (CR) after myocardial infarction (MI), which has been associated with improved outcomes. Little is known about HS attendance among foreign-born patients. The aims were to assess; 1) HS attendance in foreign-born versus native-born patients, 2) the association between the provi

Active labour market policies in emerging adulthood may act as a protective factor against future depressiveness : an analysis of the long-term trajectories of depressive symptoms in the Northern Swedish Cohort

Introduction: Drawing upon the framework of life course epidemiology, this study aligns with research on the mental health consequences of significant social transitions during early adulthood. The focus is on the variation in initial labour market attachment and the development of depressiveness, assuming that a firm attachment is associated with decreasing depressiveness. Methods: The baseline i

Cationic Micelles in Deep Eutectic Solvents: Effects of Solvent Composition

Deep eutectic solvents (DES) are mixtures of hydrogen bond donors and acceptors that form strongly hydrogen-bonded room temperature liquids. Changing the H-bonding components and their ratios can alter the physicochemical properties of deep eutectic solvents (DES). Recent studies have shown p-toluene sulfonic acid (pTSA) forms room temperature liquids with choline chloride (ChCl) at different mola

Who changes what, when and where? Elaborating postponement when integrating hardware and software objects in global supply chains

Purpose: The postponement principle concerns defining when and where value is added, usually referring to hardware components for physical products. However, in modern supply chains, software’s importance is increasing, impacting the timing and location of value-adding operations. Lacking insights into software-driven implications for postponement, we aim at elaborating on the postponement princip

How do labour market conditions explain the development of mental health over the life-course? a conceptual integration of the ecological model with life-course epidemiology in an integrative review of results from the Northern Swedish Cohort

Background: The aim of this study was to contribute to the theoretical development within the field of labour market effects on mental health during life by integrating Bronfenbrenner’s ecological model with mainly earlier theoretical work on life-course theory. Methods: An integrative review was performed of all 52 publications about labour market conditions in relation to mental health from the

Alcohol use disorder and risk of specific methods of suicide death in a national cohort

Introduction: Alcohol use disorder (AUD) is among the strongest correlates of suicide death, but it is unclear whether AUD status is differentially associated with risk of suicide by particular methods. Methods: The authors used competing risks models to evaluate the association between AUD status and risk of suicide by poisoning, suffocation, drowning, firearm, instruments, jumping, or other mean

Adverse Pregnancy Outcomes and Long-Term Mortality in Women

Importance: Women with adverse pregnancy outcomes, such as preterm delivery or preeclampsia, have higher future risks of cardiometabolic disorders; however, little is known about their long-term mortality risks. A better understanding of such risks is needed to facilitate early identification of high-risk women and preventive actions. Objective: To determine long-term mortality risks associated wi

Effekter av branschöverenskommelsen för den fossilfria leveransen: nuläge och vägar framåt

The Swedish retail landscape is currently undergoing a transformative change with increased digitalization and a rapidly growing e-commerce sector, which creates both opportunities and challenges. The development towards omnichannel commerce creates a more complex customer journey and results in complex environmental challenges. E-commerce deliveries to consumers, in particular, pose a complex soc

Information sharing in extended supply chains : why does it have to be so difficult?

Theory and practice present opposing views on whether or not companies should strive for multi-tier information sharing (MTIS) in supply chains. The purpose of this study was to identify and explore factors that influence MTIS. We performed a longitudinal Delphi study with 29 supply chain experts, including in-depth interviews and quantitative as well as qualitative analyses. Twelve contextual fac

The impact of health insurance on maternal and reproductive health service utilization and financial protection in low- and lower middle-income countries : a systematic review of the evidence

Background: Low- and middle-income countries have committed to achieving universal health coverage (UHC) as a means to enhance access to services and improve financial protection. One of the key health financing reforms to achieve UHC is the introduction or expansion of health insurance to enhance access to basic health services, including maternal and reproductive health care. However, there is a

Evaluation of the dynamic patterns of sFlt−1, PlGF and their ratio in maternal plasma from diagnosis to postpartum as a new tool for preeclampsia management

Objective: To investigate the dynamic changes of soluble fms-like tyrosine kinase−1 (sFlt−1), placental growth factor (PlGF) and their ratio in maternal plasma, from preeclampsia diagnosis to postpartum, evaluating its clinical utility. Methods: Single-center prospective longitudinal cohort study with repeated sample collection in women with established preeclampsia (PE). Seventy-five (n = 75) wom