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Objective: To determine whether a novel therapy for placental insufficiency could achieve orphan drug status by estimating the annual incidence of placental insufficiency, defined as an estimated fetal weight below the 10th centile in the presence of abnormal umbilical artery Doppler velocimetry, per 10 000 European Union (EU) population as part of an application for European Medicines Agency (EMA
We present further development and application examples of a thermometry approach capable of producing real-space temperature maps of operating nanoscale devices with sub-10nm resolution. The technique relies on scanning thermal microscopy with a resistive element coupled to a cantilevered tip. The resistive element acts both as integrated heater and as sensing element. A modulated temperature fie
The lamellar-to-sponge phase transition of fluorescently labelled large unilamellar vesicles (LUVs) of the non-ionic surfactant triethylene glycol mono n-decyl ether (C 10 E 3 ) was investigated in situ by confocal laser scanning microscopy (CLSM). Stable dispersions of micrometer-sized C 10 E 3 LUVs were prepared at 20 °C and quickly heated at different temperatures close to the lamellar-to-
One challenge to synthetic biology is to design functional machines from natural building blocks, from individual amino acids up to larger motifs such as the coiled coil. Here we investigate a novel bipedal motor concept, the Bar-Hinge Motor (BHM), a peptide-based motor capable of executing directed motion via externally controlled conformational switching between a straight bar and a V-shaped hin
This paper summarizes the state-of-the-art of the lattice matched GaInP/Ga(In)As/Ge triple-junction solar cell developed at the Solar Energy Institute of UPM (IES-UPM). Different research topics tackled over the last years about this structure are described. As result of this work, an efficiency of ∼ 40% at ∼ 415 × is presented.
Mass production of nanocrystals with accurate size control is a central problem in nanotechnology. Aerosol technology offers the possibility to produce nanocrystals with well-controlled composition and size distribution.An aerosol is defined as solid or liquid particles suspended in a gas, and aerosol science and technology has been used since over 60 years, primarily to study the size, shape and
ABSTRACT: Nanoimprint lithography (NIL) has the potential for low-cost andhigh-throughput nanoscale fabrication. However, the NIL quality and resolution areusually limited by the shape and size of the nanoimprint stamp features. Atomiclayer etching (ALE) can provide a damage-free pattern transfer with ultimate etchcontrol for features of all length scales, down to the atomic scale, and for all fea
In this work the impact of molecular inter-linker size on gold nanoparticle (AuNP) mono-/multilayer structural properties, density and homogeneity has been investigated. These characteristics are of great importance for functional binding of biomolecules. Positively charged high or low molecular weight inter-linkers, poly-L-lysine (PLL) or N-(6-mercapto)hexylpyridinium (MHP), were used to attach n
The development of microwave photon detectors is paving the way for a wide range of quantum technologies and fundamental discoveries involving single photons. Here, we investigate the photon emission from a microwave cavity and find that distribution of photon waiting times contains information about few-photon processes, which cannot easily be extracted from standard correlation measurements. The
Nonfullerene acceptors (NFAs)-based organic solar cells (OSCs) have recently drawn considerable research interests; however, their excitonic dynamics seems quite different than that of fullerene acceptors-based devices and remains to be largely explored. A random terpolymer of PBBF11 to pair with a paradigm NFA of 3,9-bis(2-methylene-(3-(1,1-dicyanomethylene)-indanone)-5,5,11,11-tetrakis(4-hexylp
In Sweden, leishmaniasis is an imported disease and its epidemiology and incidence were not known until now. We conducted a retrospective, nationwide, epidemiological study from 1993 to 2016. Probable cases were patients with leishmaniasis diagnoses reported to the Swedish Patient registry, collecting data on admitted patients in Swedish healthcare since 1993 and out-patient visits since 2001. Con
Effects of graphene ethylene glycol/water nanofluids as the hot side fluid on heat transfer and pressure drop characteristics in a brazed plate heat exchanger (BPHE) were experimentally investigated. Nanofluid properties, especially thermal conductivity and viscosity of the graphene nanofluids were measured at various graphene concentrations (0.01 to 1.0% wt.) and temperatures (10 to 60 °C). Dimen
Background: Controversy exists as to the health effects of exposure to asphalt and crumb rubber modified (CRM) asphalt, which contains recycled rubber tyres. Objective: To assess exposures and effects on airway symptoms, lung function and inflammation biomarkers in conventional and CRM asphalt road pavers. Methods: 116 conventional asphalt workers, 51 CRM asphalt workers and 100 controls were inve
Objective: Additional and comorbid diagnoses are common among suicide victims with major depressive disorder (MDD) and have been shown to increase the suicide risk. The aim of the present study was first, to investigate whether patients with severe depression/melancholia who had died by suicide showed more additional psychiatric disorders than a matched control group. Second, general rates of como
Partially premixed combustion aims to reduce NOx and particulate matter emission without fuel consumption penalty. Low temperature reactions are important for the partially premixed combustion. In the current study, a self-adaptive strategy is introduced to predict the motoring pressure by means of an equivalent isentropic index. The start of the low temperature reactions is detected when the pres
Human malignancies are often hallmarked with genomic instability, which itself is also considered a causative event in malignant transformation. Genomic instability may manifest itself as genetic changes in the nucleotide sequence of DNA, or as structural or numerical changes of chromosomes. Unrepaired or insufficiently repaired DNA double-strand breaks, as well as telomere shortening, are importa
Background: Increased blood pressure is the biggest contributor to the global burden of disease and mortality. Data suggest that less than half of the population with hypertension is aware of it. May Measurement Month was initiated to raise awareness of the importance of blood pressure and as a pragmatic interim solution to the shortfall in screening programmes. Methods: This cross-sectional surve
III-V semiconductor nanowires have attracted extensive research interests over the past few decades due to their unique geometry and great potential for promoting new functionalities in future electronics, light-emitting diodes and solar cells. However, in order to push this technology beyond the laboratory level, it is essential to combine it with the current Si-based semiconductor industry for a
Nod-like receptors (NLRs) are important innate pattern recognition receptors and regulators of inflammation or play a role during development. We systematically analysed 41 non-synonymous single nucleotide polymorphisms (SNPs) in 21 NLR genes in a Czech discovery cohort of sporadic colorectal cancer (CRC) (1237 cases, 787 controls) for their association with CRC risk and survival. Five SNPs were f
In this paper, heat transfer characteristics of natural convection in an enclosure are investigated by considering variable thermal properties. The heated enclosure with an aspect ratio of unity is full of an alumina-water nanofluid. To analyze the effect of different thermal properties on the flow and temperature distributions, many comparisons are conducted for various cases at various Rayleigh
