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Interferon-g-inducible protein 10 (IP-10) has been suggested as a marker for targeted viral load (VL) monitoring during antiretroviral treatment (ART). We aimed to determine the kinetics of IP-10 during the initial year of ART, with particular regard to the impact of tuberculosis (TB) co-infection on IP-10 secretion. Longitudinal plasma IP-10 levels were quantified in 112 treatment-naive HIV-posit

Background: Ethiopia is one of the sub-Saharan countries hit hard by the HIV epidemic. Previous studies have shown that subtype C dominates the Ethiopian HIV-1 epidemic, but the evolutionary and temporal dynamics of HIV-1 in Ethiopia have not been closely scrutinized. Understanding the evolutionary and epidemiological pattern of HIV is vital to monitor the spread, evaluate and implement HIV preven

Background: In clinic, a subjective visual estimation of a patient’s general health often guides interventions, yet little is known of how this assessment relates to objectively measured frailty. Aims: To characterize the relationship between these two assessments and explore the implication of discordance. Methods: The study was performed in the OPRA cohort of 75-year old community-dwelling women

Nanowire geometries are leading contenders for future low-power transistor design. In this study, low-frequency noise is measured and evaluated in highly scaled III-V nanowire metal-oxide-semiconductor field-effect transistors (MOSFETs) and in planar III-V MOSFETs to investigate to what extent the device geometry affects the noise performance. Number fluctuations are identified as the dominant noi

Background: Nerve growth factor (NGF) and brain-derived neural factor (BDNF) are important for brain function and detectable in the blood. This study explored the longitudinal associations of physical activity and body fat with serum NGF and BDNF in children. Methods: Two waves of measurements were performed 2 years apart in 8- to 11-year-old children, including physical activity using the ActiGra

Stretching of DNA in nanoscale confinement allows for direct visualization of the genetic contents of the DNA on the single DNA molecule level. DNA stretched in nanoscale confinement also allows for studies of DNA-protein interactions and DNA polymer physics in confined environments. This chapter describes the basic steps to fabricate the nanostructures, to perform the experiments, and to analyze

The gas flow field design plays a vital role in the cell performance of proton exchange membrane fuel cells, especially at high current densities. In this study, wavy flow channels are designed and adopted on the cathode side to enhance the mass transport process. Results demonstrate that the wavy flow channels proposed in this paper significantly improve cell performance at high current densities

For internal cooling of a turbine blade, various advanced rib turbulators can markedly contribute to the heat transfer enhancement while suffering a great increase in pressure loss. In those designs, ribs with the same configuration are periodically and evenly mounted on the channel wall. In this context, this work proposes a hierarchical design concept to optimize the rib arrangement with the des

This thesis concerns the creation of Majorana bound states (MBSs) -- a type of condensed matter excitations theorized to have exotic and technologically valuable properties. In particular, they could be used to store and manipulate quantum information in a protected way, forming the building blocks of a topological quantum computer. The search for MBSs has been intense since it was realized that t

In a VUCA world, characterized by complex, unpredictable, ambiguous and rapidly changing conditions, organizations and their managers are constantly faced with interpreting and responding to disruption. While research has investigated how disruption can be navigated, the perspective of how individual managers more concretely navigate disruption remains comparatively underexplored. The purpose

INTRODUCTION: This study examined trends in socioeconomic inequalities in obesity among Portuguese women and men using data from National Health Surveys (NHSs).METHODS: We analysed weighted data from adults aged 20-64 years from the 1998/1999 (n = 20,581), 2005/2006 (n = 13,088), 2014 (n = 7284), and 2019 (n = 5959) NHSs. Obesity was defined as body mass index (BMI) ≥30 kg/m 2, based on self-repor

Purpose: To describe the prevalence of neck pain (NP) and low back pain (LBP) of varying severity in older community-dwelling men, identify associated factors, and evaluate whether prevalent NP/LBP are risk factors for experiencing pain 5 years later. Patients and Methods: MrOS Sweden is a prospective observational study that included 3014 community-dwelling men aged 69–81 years, of whom 1962 atte

OBJECTIVE: To examine temporal changes in late diagnosis of HIV (LD) among migrant and non-migrant people with HIV in Sweden 2003-2023 and to assess demographic and socioeconomic risk factors for LD in these two populations.METHODS: People with HIV diagnosed with HIV-1 in Sweden 2003-2023 were included (n = 6278). LD was defined as a first CD4+ T-cell count <350 cells/μL or an AIDS-defining event

Background: The prevalence of urinary incontinence (UI) and fecal incontinence (FI) are conditions that increase with age. Apart from few larger studies data on prevalence and severity of UI and FI is scarce, especially among the > 80 yrs. and data of birth cohort effects is lacking. Methods: The purpose of this study was to evaluate birth cohort effects on prevalence of UI and FI in the general o

Objective: To examine temporal changes in late diagnosis of HIV (LD) among migrant and non-migrant people with HIV in Sweden 2003–2023 and to assess demographic and socioeconomic risk factors for LD in these two populations. Methods: People with HIV diagnosed with HIV-1 in Sweden 2003–2023 were included (n = 6278). LD was defined as a first CD4+ T-cell count <350 cells/μL or an AIDS-defining event