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The aim of this investigation was to assess the Ku70/Ku80 complex as a potential target for antibody imaging of prostate cancer. We evaluated the in vivo and ex vivo tumor targeting and biodistribution of the (111)In-labeled human internalizing antibody, INCA-X ((111)In-DTPA-INCA-X antibody), in NMRI-nude mice bearing human PC-3, PC-3M-Lu2 or DU145 xenografts. DTPA-conjugated, non-labeled antibody

OBJECTIVE: Serum and glucocorticoid regulated kinase 1 (SGK1) expression is increased by aldosterone and is a key regulator of the amiloride-sensitive sodium channel (ENaC) in the distal nephron. We have previously shown that two SNPs in SGK1 (rs1057293 and rs1743966) are associated with blood pressure variation and blood pressure progression in the general population. Therefore, we tested the ass

Frågor kring tillit i det digitala, tycks det, ställs oftare och oftare: Hur ska vi hantera integritets- och övervakningsfrågor? Hur ska vi hantera den mätbarhet som följer av vår digitaliserade tillvaro? Vad är det som avgör vilka tjänster vi litar på och vilka vi inte litar på, i vilken mån spelar den tekniska säkerheten en roll? Liknande frågor kan ställas om vilka kunskapsinstitutioner vi lita

Popular AbstractJordbruksmarken representerar i det beskogade boreala landskapet en aktiv åtgärd som håller skogstillväxten borta. I avhandlingen undersöks lantbrukares praktiska beslutsfattande i samband med den öppna marken på gårdar som i Sverige ofta består av både jordbruks- och skogsmark. Som teoretiska ramverk används begreppen tidrum, landskap, orientering och åtagande för att förstå lantbThe human-induced open land (cropland, pasture) in the predominantly forested boreal landscapes relies on arable land use; it thus represents an active intervention to hold back forest regrowth. The thesis investigates the practical management decisions by landholders on discrete farms, which in Sweden often comprise both forest and arable lands. The theoretical framework utilizes the concepts tim

Popular Abstract in Swedish Att få inopererat en höft- eller knäprotes är numera ett vanligt ingrepp. Under 80-talet visade svenska och utländska studier att 10-15% av de patienter som genomgick en sådan höftoperation drabbades av försämrad njurfunktion efter operationen. Denna försämring var övergående men kunde vara allvarlig för patienten, och kostsam för sjukvården, under den tid den kvarstod.Total hip replacement (THR) is a common procedure, generally performed in elderly persons. Previous studies indicated that the use of isoxazolyl penicillins could induce a transient post-operative renal dysfunction in these patients. By measuring urinary levels of markers for glomerular (albumin, IgG) and tubular (protein HC) function we studied the influence of systemic cloxacillin, the gentamic

Emergence of multiple-function products (MFPs) poses a variety of challenges and risks for achieving sustainable consumption and production as well as fair consumer society and universal design. We overviewed MFPs from these viewpoints and then, focusing on product standard as a means to create mechanisms to reduce environmental loads from products, elucidated advantages and limitation of five app

Internationalisation of higher education is a current theme in research and politics of higher education. The theme in this paper is related to present developments and concerns of the growing border-crossing activities that take place between nations and their systems of Higher Education. Higher education is expected to be based on research, research to be an international activity, and the unive

A low-weight aerosol sampler has been developed and tested. Internal losses for both sub-micron and large particles ( < 10 tam) are of the order of 5 %. The size fractionation patterns indicate that the sampler may be used to collect a separate respirable fraction in good agreement with the BMRC standard and a coarse fraction deternuned by the inlet design.

Popular Abstract in Swedish Cerebral pares (CP) drabbar drygt 2 barn per 1000 födda och är den vanligaste orsaken till rörelsehinder hos barn och ungdomar. På latin betyder CP "förlamning från hjärnan" och är ett samlingsnamn för ett följdtillstånd efter en skada i den omogna hjärnan under dess utveckling från fosterstadiet t o m 2-års ålder. Skadan är av engångskaraktär men de olika symtomen föräCerebral palsy (CP) is a term for a group of conditions associated with motor disabilities, that are very heterogeneous, i.e. symptoms, severity, associated impairments, functional outcome and needs. The overall purpose of this thesis was to study the prevalence and gross motor function and to evaluate and adapt measurements in children with CP. The prevalence in Southern Sweden was 2.4 per 1000 c

We present novel coupling schemes for partitioned multiphysics simulation that combine four important aspects for strongly coupled problems: implicit coupling per time step, fast and robust acceleration of the corresponding iterative coupling, support for multirate time stepping, and higher-order convergence in time. To achieve this, we combine waveform relaxation—a known method to achieve higher-

Writing is a central activity at university. Writing in English at University: A Guide for Second Language Writers is a textbook designed to accompany the MOOC Writing in English at University. It can also be used as a stand-alone handbook, with links to online resources, such as instructional videos on key aspects of academic writing provided throughout.Just like the MOOC, this textbook targets u

The distinct lineage potential is a key feature of hematopoietic stem cell (HSC) heterogeneity, but a subset of HSCs specialized for a single lymphoid compartment has not been identified. Here we report that HSCs expressing junctional adhesion molecule 2 (Jam2) at a higher level (Jam2high HSCs) have a greater T cell reconstitution capacity. Jam2high HSCs are metabolically dormant but preferentiall