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Objectives Critically ill COVID-19 patients admitted to the intensive care unit (ICU) are at an increased risk of acquiring bacterial bloodstream infections (BSI). We aimed to describe patient characteristics, risk factors, and the microbiological spectrum in blood cultures and evaluate the impact of ICU-acquired BSI on outcomes in a Nordic setting. Methods A prospective multicenter cohort study w

AbstractBackgroundThe role of nutrient intake in celiac disease pathogenesis is poorly understood.ObjectiveTo examine whether longitudinal childhood intake of selected vitamins and minerals is associated with celiac disease autoimmunity (CDA, primary outcome) and celiac disease (secondary outcome) in genetically at-risk children.MethodsA total of 6,520 HLA-conferred at-risk children in the observa

Whereas the link between impaired male fertility and risk of testicular and prostate cancer is well established, studies investigating non-reproductive cancer risk among men with impaired reproductive function are scarce and show conflicting results. The aim of the study was to compare the risk of developing non-reproductive cancers in men achieving paternity through assisted reproduction as compa

Air pollution has been linked to reduced birthweight, but the association with black carbon (BC) remains insufficiently explored. This study examined the association of gestational exposure to BC with birthweight outcomes. We included data on all singleton births in Denmark between 2004 and 2016 (n = 690,898). BC and fine particulate matter (PM2.5) were estimated by high-resolution air pollution m

Growth and immune development—fundamental parts of any organism's ontogeny—depend critically on nutrient availability, particularly on essential amino acids that support protein synthesis and physiological processes. However, environmental variation can reduce prey diversity and nutrient quality, producing suboptimal diets that lack essential amino acids, potentially constraining development. In t

ObjectivesAutoantibodies against tissue transglutaminase (tTG) are serological markers of celiac disease. The aim was to study the applicability of human leukocyte antigen (HLA)-genotyping and tTG autoantibodies in the screening of celiac disease in a longitudinal birth cohort followed to age 15 years.MethodsIncluded were 13,860 HLA-DQ-genotyped children at birth and previously invited to a screen

ObjectivesOur aim was to study the association between residential land cover and greenness during childhood and risk of developing celiac disease (CeD).MethodsThe Celiac Prediction in Skåne study prospectively followed 5969 human leukocyte antigen (HLA)-genotyped children born 2001–2004 who were screened for CeD at ages 3, 9, and 15 years in Skåne, Sweden. Among these, 138 (2.3%) children only in

Lung transplantation (LTx) remains the only curative treatment for patients with end-stage lung disease, yet long-term outcomes remain inferior to those of other solid organ transplantations, with a 5-year survival below 70%. Major contributors to this limited outcome include primary graft dysfunction (PGD), the leading cause of early mortality, chronic lung allograft dysfunction (CLAD), and low u

Natural autoantibodies (NAAbs) are immunoglobulins generated in the absence of antigen provocation, with no inherent pathogenic effect, but instead involved in maintaining immune homeostasis. We aimed to evaluate the implication of immunoglobulin G (IgG) antibodies against heat shock protein 90α (HSP90α) in systemic lupus erythematosus (SLE) patients, focusing on how those NAAbs may interfere with

Controlling the surface morphology and chemical interaction is necessary for the development of advanced quantummaterials, particularly in low-dimensional systems. As the research increasingly focuses on miniature and nanoscaletechnologies, a fundamental understanding of localized or interface states becomes essential for successful integrationinto functional devices. This thesis investigates atom

Background: Celiac disease is associated with HLA-risk haplotypes, but non-HLA genes and environmental factors are also linked to disease susceptibility. In this study, we explore the molecular pathways involved in celiac disease by analyzing the differential expression of genes in both the gut and peripheral blood across various celiac disease phenotypes. Methods: Whole genome RNA sequencing was

The study aimed to investigate the unique lipid composition of Mycobacterium bovis BCG and its potential to enhance antimicrobial efficacy of lipid-coated mesoporous silica particles (MSPs). The bacterial lipids (BL) were extracted with petroleum ether and analyzed via LC-MS, revealing a complex mixture of phospholipids, including cardiolipin, phosphatidylcholine, phosphatidylethanolamine, and tri

Additives such as binders and hydrophobic agents are commonly introduced into the fibrous Gas Diffusion Layer (GDL) of proton exchange membrane fuel cells to enhance mechanical strength and facilitate water management. However, the effect of additive/fiber content and surface wettability on water removal, oxygen diffusion, and heat conduction remains insufficiently understood. In this work, we dev

Background: Microscopic colitis (MC) is characterized by non-bloody, watery diarrhea predominantly in elderly women. Known risk factors are smoking, medication with NSAIDs, PPIs or SSRIs, while data on hormonal factors is sparse. The aim of the present study was to investigate whether hormonal factors that disrupt the sex hormonal balance could have an impact on the disease course in MC. Methods:

Background: Evidence is limited on whether alterations in diabetes-related health parameters are detectable before clinical diagnosis in novel diabetes subtypes. We investigated trajectories of diabetes-related health parameters in individuals with recently diagnosed type 2 diabetes (T2D). Methods: Using data from the Stockholm Diabetes Prevention Programme cohort (SDPP) participants (n = 215) wit