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Family history as a risk factor for recurrent hospitalization for lone atrial fibrillation: a nationwide family study in Sweden.

ABSTRACT: BACKGROUND: Although the heritability of atrial fibrillation (AF) has been determined, the relevance of family history of AF for the likelihood of recurrent hospitalization for AF is unknown. The aim of this nationwide study was to determine whether family history of AF is a risk factor of recurrent hospitalization for lone AF (LAF), i.e., AF with unknown etiology. The familial risk f

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22

Objectives Osteoarthritis (OA) is the most prevalent form of arthritis and accounts for substantial morbidity and disability, particularly in older people. It is characterised by changes in joint structure, including degeneration of the articular cartilage, and its aetiology is multifactorial with a strong postulated genetic component. Methods A meta-analysis was performed of four genome-wide asso

High Current Density InAsSb/GaSb Tunnel Field Effect Transistors

Steep-slope devices, such as tunnel field-effect transistors (TFETs), have recently gained interest due to their potential for low power operation at room temperature. The devices are based on inter-band tunneling which could limit the on-current since the charge carriers must tunnel through a barrier to traverse the device. The InAs/GaSb heterostructure forms a broken type II band alignment wh

Too many calories, too few nutrients? : a systems approach to food and nutrition security in Guatemala

Obesity levels in developing countries are increasing at an alarming rate, while “old” problems such as hunger and undernutrition still persist, creating a paradoxical situation of a double burden of malnutrition. Intertwined with new sustainability challenges such as climate change and land degradation, food, health and sustainability are interconnected in a complex web of relationships, spanning

Reseavdrag och miljöpolitik

Reseavdraget – Motverkar det politiska spelet incitament som kan förbättra miljön? Reseavdraget, att vara berättigad till att dra av en del av kostnaderna som uppkommer till följd av resor till och från arbetsplatsen på skatten, har förundrat mig under flera år. Är reseavdraget rättvist utformat, belönar det ett samhällsekonomiskt olönsamt val eller kan det skapa incitament för arbetspendlare attIncome Tax-deduction for commuting expenses has been criticised and discussed for a long time without having reached any conclusions or reformations. Critical opinions in the debate are that a reformation would disfavour taxpayers living in the countryside with no options except car commuting and decreasing size of labour market regions. At the same time tax evasion is a huge problem because taxpa

Lactoferrin-derived peptide PXL01 impacts nerve regeneration after sciatic nerve reconstruction in healthy and diabetic rats

INTRODUCTION: Although advanced surgical techniques are available, satisfactory functional outcomes after peripheral nerve injuries are uncommon. Hence, immune-modulating factors such as PXL01, a lactoferrin-derived peptide that improves axonal outgrowth in injured human digital nerves, have gained attention. We previously reported a short-term immunosuppressive effect of PXL01 after the repair of

Prospective Assessment of Clinically Relevant Fluid Balance Thresholds Associated With Postoperative Complications in Advanced Ovarian Cancer

Background: Reliable data on optimal fluid management in the perioperative period for patients with advanced ovarian cancer undergoing cytoreductive surgery is limited. These patients often present with malignant ascites and are prone to significant fluid shifts perioperatively. For this reason, our objective was to define clinical targets for optimal fluid balance and determine whether initial as

Mini-review of the EAT-Lancet planetary health diet and its role in cardiometabolic disease prevention

Human diets play a crucial role in both human health and environmental sustainability. In 2019, the EAT-Lancet Commission on healthy diets from sustainable food systems introduced the EAT-Lancet planetary health diet, a universal reference diet designed to promote human health while minimizing environmental degradation. It is a predominantly plant-based dietary pattern, rich in whole grains, veget

Protection Against Pneumonia Induced by Vaccination with Fimbriae Subunits from Klebsiella pneumoniae

Background: Klebsiella pneumoniae infections pose a great burden worldwide, causing high morbidity and mortality, which are worsened by the increase in multidrug-resistant strains. New therapeutic/prophylactic strategies are urgently needed to overcome antibiotic resistance and reduce the health and economic impacts of diseases caused by this pathogen. Fimbriae are important virulence factors invo

Uppdragsunderskridanden och feltolkning av processhandlingar

17 kap. 3 § rättegångsbalken (RB) omgärdas av omfattande begrepps- och teoribildning. Som exempel har det skrivit tre svenska avhandlingar som har bestämmelsen som huvudtema. När det kommer skiljeförfaranden enligt lagen (1999:116) om skiljeförfarande (LSF) är det en omdebatterad fråga i vad mån tvistemålsprocessens begrepps- och teoribildning bör tillämpas analogt. LSF har ingen uttrycklig bestäm

Solution and Interfacial Properties of Cyclic Containing Anionic Surfactants

The bulk micellar and surface adsorption behaviour of a bio-derived cyclic-containing anionic surfactant, sodium tetradecyl furan sulfonate (STFS), has been studied in this work. To determine its viability as an alternative to petrochemically derived surfactants in detergents, the self-assembly andadsorption properties were measured both alone and in binary and ternary mixtures with a common anion

Prognostic performance of preoperative cardiac troponin and perioperative changes in cardiac troponin for the prediction of major adverse cardiac events and mortality in noncardiac surgery : A systematic review and meta-analysis

Background Increased postoperative cardiac troponin (cTn) independently predicts short-term mortality. Previous studies suggest that preoperative cTn also predicts major adverse cardiovascular events (MACE) and mortality after noncardiac surgery. The value of preoperative and perioperative changes in cTn as a prognostic tool for adverse outcomes has been sparsely investigated. Methods and findings

Arbetstagares kritikrätt - Skillnader mellan offentlig och privat sektor samt implikationer av Europadomstolens praxis

Det ena syftet med denna uppsats är att undersöka skillnaderna mellan den offentliga och den privata sektorn ifråga om arbetstagares kritikrätt. Det andra syftet är att undersöka konsekvenserna för denna rättighet av en dom från Europadomstolen, Fuentes Bobo mot Spanien. Offentligt anställda har en grundlagsskyddad yttrandefrihet, som kan utnyttjas i princip i vilken situation som helst. Begränsni

In early rheumatoid arthritis, patients with a good initial response to methotrexate have excellent 2-year clinical outcomes, but radiological progression is not fully prevented: data from the methotrexate responders population in the SWEFOT trial

Objective To investigate the 2-year clinical and radiological outcomes of patients with early rheumatoid arthritis (RA; symptom duration <1 year) who had initially responded well to methotrexate monotherapy. Methods In the SWEFOT trial, all 487 patients started methotrexate (target dose 20 mg/week). After 3-4 months, 147 had low disease activity, 28-joint based disease activity score (DAS28) <= 3.

A healthy diet with and without cereal grains and dairy products in patients with type 2 diabetes: study protocol for a random-order cross-over pilot study - Alimentation and Diabetes in Lanzarote -ADILAN.

Research on the role of nutrition in type 2 diabetes has largely focused on macro/micronutrient composition and dietary fiber intake, while fewer studies have tested the effects of differing food choice. Some observational studies and short-term intervention studies suggest that a food pattern mimicking the diet with which humans evolved positively influences glucose control and associated endocri

Fluid and Highly Curved Model Membranes on Vertical Nanowire Arrays

Sensing and manipulating living cells using vertical nanowire devices requires a complete understanding of cell behavior on these substrates. Changes in cell function and phenotype are often triggered by events taking place at the plasma membrane, the properties of which are influenced by local curvature. The nanowire topography can therefore be expected to greatly affect the cell membrane, emphas

Evaluation of A2BP1 as an Obesity Gene

OBJECTIVE-A genome-wide association study (GWAS) in Pima Indians (n = 413) identified variation in the ataxin-2 binding protein 1 gene (A2BP1) that was associated with percent body fat. On the basis of this association and the obese phenotype of ataxin-2 knockout mice, A2BP1 was genetically and functionally analyzed to assess its potential role in human obesity. RESEARCH DESIGN AND METHODS-Variant

The massive O(N) non-linear sigma model at high orders

We extend our earlier work on the massive O(N) non-linear sigma model to other observables. We derive expressions at leading order in the large N expansion at all orders in the loop expansion for the decay constant, vacuum expectation value, meson meson scattering and the scalar and vector form factors. This is done using cactus diagram resummation using a generalized gap equation and other recurs