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A 61-year-old male patient presented with rest pain and ulceration in his left leg 1 week after a hybrid procedure with bilateral external iliac stenting, common femoral artery thromboendarterectomy, and left-sided femoral popliteal bypass with an in situ saphenous vein. The bypass had been stented intraoperatively but had again become occluded directly after surgery. In the present report, we dem
In the purple phototrophic bacterium Rhodobacter sphaeroides, light harvesting LH2 complexes transfer absorbed solar energy to RC-LH1-PufX core complexes, which are mainly found in the dimeric state. Many other purple phototrophs have monomeric core complexes and the basis for requiring dimeric cores is not fully established, so we analysed strains of Rba. sphaeroides that contain either native di
Treatment of chronic osteomyelitis by radical debridement and filling of the dead space with antibiotic containing calcium sulphate/hydroxyapatite (CaS/HA) bone substitute has shown excellent long-term outcomes. However, in extensive infections, sessile bacteria may remain in bone cells or soft tissues protected by biofilm leading to recurrences. The primary aim of this study was to evaluate if sy
Ice-marginal moraines are widely used as indicators of palaeoclimate in mountainous regions, yet the genetic processes of their formation remain incompletely understood. Here, we present new data on the geomorphology and sedimentology of annually formed moraine ridges in the foreland of Gornergletscher, Switzerland, with the aim of reconstructing the processes of their formation, assessing their p
Universities are increasingly being seen as a positive vehicle for territorial development and regional transformation, with an important role in enhancing Social, Economic and Sustainable Development of territories. The world’s sustainability challenges are listed in the United Nation’s Agenda 2030, that includes Higher Education Institutions (HEIs) as actors that can work in partnership with oth
We obtain large n asymptotics for the m-point moment generating function of the disk counting statistics of the Mittag-Leffler ensemble, where n is the number of points of the process and m is arbitrary but fixed. We focus on the critical regime where all disk boundaries are merging at speed n − 1 2 , either in the bulk or at the edge. As corollaries, we obtain two central limit theorems and preci
Pebble accretion is recognized as a significant accelerator of planet formation. Yet only formulae for single-sized (monodisperse) distribution have been derived in the literature. These can lead to significant underestimates for Bondi accretion, for which the best accreted pebble size may not be the one that dominates the mass distribution. We derive in this paper the polydisperse theory of pebbl
The advent and popularity of shared electric scooters in many urban areas worldwide offer new opportunities and challenges to be addressed by the research community, especially as far as safety and accessibility issues are concerned. This paper proposes a methodology, based on geofencing technology (i.e., virtual geographic boundaries) to define in which urban areas the speed of shared electric sc
Background. We investigated how varying the treatment margin and applying hippocampal sparing and proton therapy impact the risk of neurocognitive impairment in pediatric medulloblastoma patients compared with current standard 3D conformal radiotherapy. Methods. We included 17 pediatric medulloblastoma patients to represent the variability in tumor location relative to the hippocampal region. Trea
This study investigated the dosimetric impact of uncompensated motion and motion compensation with dynamic multileaf collimator (DMLC) tracking for prostate intensity modulated arc therapy. Two treatment approaches were investigated; a conventional approach with a uniform radiation dose to the target volume and an intraprostatic lesion (IPL) boosted approach with an increased dose to a subvolume o
Recent advances in therapeutics are now providing a wide range of options for adults and children living with hemophilia. Although therapeutic choices are also increasing for the youngest individuals with severe disease, challenges remain about early management decisions, as supporting data are currently limited. Parents and healthcare professionals are tasked with helping children achieve an incl
Responsible internationalization has become an increasingly used term to promote relationship building in a world which is increasingly shaped by the growing impact of global challenges and geopolitical competition. Amidst these changing global conditions researchers and universities have started to learn that they need to adhere to an expanded set of norms related to the research endeavor. Today
Analysis of an individual's immunoglobulin or T cell receptor gene repertoire can provide important insights into immune function. High-quality analysis of adaptive immune receptor repertoire sequencing data depends upon accurate and relatively complete germline sets, but current sets are known to be incomplete. Established processes for the review and systematic naming of receptor germline genes
Purpose: Medical imaging is crucial in modern radiotherapy, aiding diagnosis, treatment planning, and monitoring. The development of synthetic imaging techniques, particularly synthetic computed tomography (sCT), continues to attract interest in radiotherapy. The SynthRAD2025 dataset and the accompanying SynthRAD2025 Grand Challenge aim to stimulate advancements in synthetic CT generation algorith
Motivation Efforts to address health disparities are often limited by the lack of robust computational tools for inferring genetic ancestry by calculating an individual's genetic similarity to continental groups. We have already shown that a preferred alternative to self-described race is using ancestry-informative markers (AIMs) that can be classified into ancestral components and used to estimat
According to previous research, young children’s numeracy skills may be scaffolded by practicing on the number line. A number line estimation task (NLET) is often conducted with pen and paper, while linear number games are often implemented on a computer or a tablet. If and how the format—physical or digital—influences the accuracy of the estimations is, however, not well-known. If regarding NLET
