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α-CGRP 8-37 is a peptide fragment of calcitonin gene-related peptide and is commonly used as a CGRP antagonist in pharmacological research. CGRP signaling has been discussed in relation to neuroimmune mechanisms in psoriasis, but a practical development of α-CGRP 8-37 requires analytical methods and formulation strategies that can handle peptide instability, adsorption, and matrix effects. The aim
This thesis investigates the design and evaluation of Large Language Model (LLM) agent assistants for industrial maintenance, developed in cooperation with SSAB. The study focuses on identifying what combinations of tools and architectures best serve the needs of maintenance technicians, with an emphasis on practical usability and factual correctness. Multiple agents were developed and compared,
Cybersecurity has never been more relevant than it is today, as attacks become increasingly sophisticated. To keep devices safe from threats, a new type of smart firewall has become an active area of research. This type of firewall can dynami- cally configure itself based on incoming network traffic using reinforcement learn- ing. This research has shown promising results; however, its impact on r
Energy management in cold logistics is critical for sustainable cold chain transportation. However, conventional reactive temperature control strategies often induce excessive energy consumption and mechanical wear due to rigid air temperature tracking and inability to anticipate system thermal dynamics. Guided by the Design Science Research (DSR) methodology, this study proposes a simulation-base
This thesis develops a Fourier-feature DeepONet surrogate model for predicting two-dimensional steady laminar flow fields around a rotating triangular obstacle. The aim is to learn the mapping from the obstacle rotation angle to the corresponding pressure, x-velocity, and y-velocity fields. A CFD dataset containing 121 cases was generated using ANSYS Fluent, covering rotation angles from 0° to 120
Non-terrestrial networks (NTNs) are expected to become an important component of future sixth-generation (6G) wireless systems by extending broadband coverage to remote, maritime, aerial, and underserved areas. Among different NTN platforms, low Earth orbit (LEO) satellite constellations are particularly attractive due to their lower propagation delay compared with geostationary systems. However,
Many consumers say they want to shop more sustainably. But most retail websites do not make that easy. Walk through a typical online furniture store, and you will find sustainability information buried in product specifications or tucked away behind a separate filter tab. This happens right when you are already trying to balance price, looks, and whether the thing will actually fit in your living
This study aimed to examine how interrogation techniques in the form of alpha and omega strategies, as well as a rapport-based approach by the interviewer, were related to engagement and information disclosure in intelligence interviews. The study was conducted through observation and coding of 66 interviews involving a total of 19 interviewees and 6 interviewers in a training-based and realistica
Milk protein compositions play a pivotal role in physicochemical and technological properties of milk, particularly in rennet coagulation in cheese production. Conventional analytical methods such as sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and liquid chromatography–high resolution mass spectrometry (LC-HRMS) provide detailed protein characterization but require long an
This thesis presents an automated pipeline developed for reconstructing the 3D flight trajectories of bats navigating a cave environment purely from multi-channel audio recordings. The pipeline was developed and validated using the Ushichka dataset which contains multiple simultaneous audio and video recordings of bats in their natural habitat, the Orlova Chuka cave in Bulgaria. The proposed pipel
This project involved the testing and establishment of a base combustion procedure for the newly acquired Raddec Gen IV PYROLYSER and focused on the optimization and correction of the laboratory’s previous liquid scintillation counting (LSC) procedure using the Hidex 300 SL. The pyrolyser was verified to be operational and achieve satisfactory and consistent recoveries across the 6 combustion tub
This guide Addressing Inner Dimensions for Sustainability in Higher Education is aimed at Higher Education faculty from diverse disciplines. The target group is interested in expanding their sustainability knowledge and perspectives, integrating sustainability into their teaching practices, and enhancing their sustainability-related teaching approach by addressing inner dimensions. By inner dimens
Studien undersöker hur vi kan förstå AI för emotionellt- eller mentalt stöd, genom användares egna berättelser och diskussioner om denna typ av AI-användning. Syftet med undersökningen är att bidra till fördjupad sociologisk kunskap om hur användare upplever och tolkar stödet för att det ska bli meningsfullt och användbart för emotionellt- eller mentalt välbefinnande. Ämnet är fortfarande relativt
När ett nedslag gräver upp och modifierar Mars yta, genom att medföra material från djupare delar till ytan, öppnar det fönster ner till äldre geologi. Att försöka förstå ytegenskaper på Mars och hur källmaterialet beter sig vid ett nedslag kräver en metod från flera perspektiv. Tidigare forskning har främst fokuserat på ejecta och ejektamorfologi som en indikator på ytegenskaper. Däremot kan ävenWhen an impact excavates and modifies the Martian surface, by bringing deeper lying material to the surface, it opens a window into past geology. Trying to understand surface properties on Mars and how target material behaves during impact requires a multi-view approach. Previous research has focused mainly on ejecta emplacement and morphologies as a proxy for surface properties. However, interior
Dark matter remains a largely elusive phenomenon, particularly its composition. Several candidate particles have been proposed, including axions and axion-like particles (ALPs). Detection of axions and ALPs have been attempted but none so far have yielded positive results. The High Intensity Baryon Extraction and Measurement instrument (HIBEAM) at the European Spallation Source (ESS) will be used
Direct-to-Device (D2D) communication in Non-Terrestrial Networks (NTNs) enables smartphones to connect directly to satellites, extending wireless coverage beyond terrestrial networks. This thesis presents the design of a smartphone antenna optimized for NTN operation, followed by a link budget analysis and Electromagnetic Field (EMF) exposure assessment. The proposed solution is a dual-band circu
OBJECTIVE: Avacopan (AVAC), an oral selective C5a receptor inhibitor, has been approved for treatment in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Outside randomized controlled studies, real-world data are scarce. The aim of this study was to provide further insight into the clinical experience of AVAC.METHOD: We analysed data from 16 patients with severe AAV include
Accurate mapping of earthquake-damaged buildings is essential for rapid post-disaster assessment and urban recovery planning. Very high-resolution (VHR) satellite imagery enables large-scale geospatial damage detection; however, conventional convolutional neural networks (CNNs) often struggle to model complex spatial dependencies and nonlinear damage patterns efficiently. To address these limitati
