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BackgroundDietary shift is necessary for improving public health, mitigating climate change, and achieving the Sustainable Development Goals. Adaption of climate-friendly diets might prevent chronic diseases and reduce mortality; however, consuming diets with a low climate impact have been suggested to increase risk of some micronutrient deficiencies.ObjectivesThis study aimed to examine whether s

The presence of microplastics (MPs) in water represents a current problem for marine life and a future serious issue for human health. This is pushing towards new approaches for the removal of MPs and, hence, their characterization and evaluation, which up to now has represented a limit for tentative procedures for their degradation. Herein, we reported on a new facile, in situ and non-destructive

Background and Aims: Previous studies have shown that procalcitonin (PCT) concentration is elevated in patients with liver disease without evidence of bacterial infection. We aimed to investigate the association between elevated PCT and the future risk of liver disease. Method: PCT was measured in 3897 individuals without known liver disease in the Malmö Diet and Cancer Cardiovascular Cohort (MDC-

Background: Regular monitoring of healthcare quality and equity is crucial for informing decision-makers and clinicians. This study explores the application of generative AI, more specifically large language models (LLMs), to facilitate standardized monitoring of healthcare quality using the established framework Analysis of Individual Heterogeneity and Discriminatory Accuracy (AIHDA). The study i

BACKGROUND: Despite the high level of economic development in the Group of Seven (G7) countries, injury deaths remain a public health concern in these countries. This paper examines the contribution of injury deaths to changes in life expectancy (LE) and life disparity (LD) in the G7 countries.METHODS: We used annual data from the WHO mortality database to compute LE and LD during 2001-03 and 2017

Combining multiple III-V materials into axial nanowire heterostructures has enabled the fabrication of custom nanowire-based devices useful for a wide range of applications. However, our ability to form axial heterostructures between arbitrary combinations of III-V compounds is impeded by a lack of information on the dynamics of the heterojunction formation process, often resulting in suboptimal h

RNA modifying enzymes play a pivotal role in reshaping gene expression programs in response to diverse intracellular and extracellular cues, thereby maintaining cellular homeostasis. When dysregulated, these enzymes are increasingly implicated in the onset and progression of various diseases. While traditionally recognised for their catalytic functions, mounting evidence suggests that many RNA mod

Binary nanoparticles (BNPs), composed of two distinct materials, offer tailored properties advantageous for various applications, including enhanced catalytic, magnetic, and optical behavior. Among the synthesis methods for BNPs, spark ablation stands out for its capability to produce multicomponent nanostructures with tunable compositions. This study investigates the mixing dynamics of material v

Glial fibrillary acidic protein (GFAP) is a type-3 intermediate filament protein mainly expressed in astrocytes in the central nervous system. Mutations in GFAP cause Alexander disease (AxD), a rare and fatal neurological disorder. How exactly mutant GFAP eventually leads to white and gray matter deterioration in AxD remains unknown. GFAP is known to be expressed also in neural precursor cells in

Approaches to differentiating pluripotent stem cells (PSCs) into neurons currently face two major challenges-(i) generated cells are immature, with limited functional properties; and (ii) cultures exhibit heterogeneous neuronal subtypes and maturation stages. Using lineage-determining transcription factors, we previously developed a single-step method to generate glutamatergic neurons from human P

Droplet splitting plays an important role in droplet microfluidics by providing precise control over droplet size, which is essential for applications such as single-cell analysis, biochemical reactions, and the fabrication of micro- and nanosized material. Conventional methods of droplet splitting using obstructions or junctions in the microchannel have a clear limitation that the split ratio for

Background: The use of unique national personal identification numbers (PIN) for linkage of medical records across health facilities and population-based studies is limited in sub-Saharan Africa (SSA) countries. The disintegration of healthcare research with different participant identifiers creates methodological challenges in linking data from multiple sources to answer a diverse range of policy

Due to their high aspect ratio and increased surface-to-foot-print area, arrays of vertical semiconductor nanowires are used in numerous biological applications, such as cell transfection and biosensing. Here we focus on two specific valuable biosensing approaches that, so far, have received relatively limited attention in terms of their potential capabilities: cellular mechanosensing and lightgui

Majoriteten av världens extremt fattiga bor i rurala områden och 300 miljoner av dem i Indien och Kina. Trots att länderna kommit en bit på vägen i sin strukturella omvandling arbetar fortfarande runt hälften av befolkningen på landsbygden inom jordbruket. De direkta och indirekta effekterna som den primära sektorn skapar har visat sig viktiga av olika anledningar. Hur detta kommer sig undersöks n

Cell replacement therapies in Parkinson's disease (PD) aim to provide long-lasting relief of patients' symptoms. Previous clinical trials using transplantation of human fetal ventral mesencephalic (hfVM) tissue in the striata of PD patients have provided proof-of-principle that such grafts can restore striatal dopaminergic (DA-ergic) function. The transplants survive, reinnervate the striatum, and

Context: Robot-assisted laparoscopic radical prostatectomy (RALP) using the da Vinci Surgical System (Intuitive Surgical, Sunnyvale, CA, USA) is now in widespread use for the management of localised prostate cancer (PCa). Many reports of the safety and efficacy of this procedure have been published. However, there are few specific reports of the limitations and complications of RALP. Objective: Th

Patent foramen ovale (PFO) is present in approximately 25% of the general population. PFO is characterized by intermittent shunting of blood from the right to the left atrium, especially in the context of increased right-sided filling pressures, with risk of paradoxical embolism. We describe a 69-year-old woman presenting with acute chest pain, severe dyspnoea, and acute inferolateral ST-segment e

Although Rac and its activator Tiam1 are known to stimulate cell-cell adhesion, the mechanisms regulating their activity in cell-cell junction formation are poorly understood. Here, we identify beta 2-syntrophin as a Tiam1 interactor required for optimal cell-cell adhesion. We show that during tight-junction (TJ) assembly beta 2-syntrophin promotes Tiam1-Rac activity, in contrast to the function o