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Background: Pro-neurotensin (pro-NT) is the stable circulating precursor of neurotensin (NT), a neuropeptide expressed mainly in the central nervous system and small intestine that regulates key physiological processes like fatty acid absorption in the gut and suppresses appetite via central mechanisms. Studies in NT-deficient mice and humans implicate NT in obesity and insulin resistance, highlig
Hyperbolic phonon polaritons - hybridized modes arising from the ultrastrong coupling of infrared light to strongly anisotropic lattice vibrations in uniaxial or biaxial polar crystals - enable to confine light to the nanoscale with low losses and high directionality. In even lower symmetry materials, such as monoclinic (Formula presented.) -Ga2O3 (bGO), hyperbolic shear polaritons (HShPs) further
Aims: Testing insulin resistance could help improve physician assessment of patients’ risk of prediabetes or type 2 diabetes (T2D), even among normoglycemic individuals. Methods: The longitudinal study followed 16,333 normoglycemic participants in a nation-wide employer-sponsored health assessment program starting in August 2020 with a median follow-up time of 2.9 years for incident prediabetes or
The Swedish music and arts school (SAMS) has been described as “a foundation for Swedish culture, where children and youth are given opportunities to express themselves through dance, fine art, drama, music or other art forms” (Öhrman & Holmdahl, 2022, s. 103). Current debates have questioned SAMS capacity to meet contemporary needs, revolving around themes such as broadening of target groups,
Several factors contribute to the use, non-use, or inadequate use of personal protective equipment (PPE) in construction work. This study aimed to analyse correct usage of various PPE, such as helmet, ear protectors, goggles, respiratory mask, gloves, protective clothing, and a safety harness. Correct usage was assessed as guessability, which refers to human perceptions of how to don, adjust, use,
ObjectivesTo compare head acceleration between blind football players and non-disabled football players, and between anticipated and unanticipated conditions in blind football players.DesignLaboratory-based exploratory study.MethodsParticipants were ten football players (five blind football, five non-disabled; 80% female). Standardized head perturbations were applied in flexion, extension, lateral
Personal Protective Equipment (PPE) noncompliance has been addressed through various lenses. In current literature, there is a greater focus on improving training and safety culture. Improving PPE design to persuade PPE compliance is less explored, especially in sectors beyond healthcare. This study investigates the reasons behind PPE noncompliance across construction, maritime, and chimney sweepi
The energy system is undergoing significant changes and is expected to continue to evolve. Energy demand is anticipated to increase, as is renewable energy capacity, and technical solutions are advancing. For electrical power, traditionally centralized production is increasingly complemented by distributed production, transforming fundamental system functionality. These developing factors will aff
Objective: Interstitial lung disease (ILD) can occur in association with antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV-ILD) or as an isolated entity with positive ANCA (ANCA-ILD). However, data on the epidemiology and outcomes of these conditions remain limited. Methods: A European multicenter retrospective study encompassed patients with AAV-ILD or ANCA-ILD. Baseline and s
Bacteria encode diverse defence systems, including restriction-modification and CRISPR-Cas, that cleave nucleic acid to protect against phage infection. Bioinformatic analyses demonstrate that many recently identified antiphage defence operons comprise a nuclease and NTPase protein, suggesting that additional nucleic acid-targeting systems remain to be understood. Here we develop large-scale compa
Long RSH enzymes, Rel and RelA, are master regulators of bacterial (p)ppGpp alarmones levels. Bifunctional Rel transitions between a compact hydrolysis-competent (HD ON) state, a relaxed catalytically inactive (HD OFF/SYNTH OFF) state, and an elongated synthesis-competent (SYNTH ON) state, whereas RelA samples only the latter two. The distribution of these states is controlled by starved ribosomes
BACKGROUND: The major pathways contributing to cardiovascular disease among night shift workers remain poorly understood. MicroRNAs (miRNAs) have been identified as novel regulators of cardiovascular risk factors. Our objective was to examine whether night shift work was associated with altered expression of five cardiovascular-related miRNAs in night and day shift workers.METHODS: RNA was extract
A set of ultrawide bandgap single-crystal NdGaO3 samples cut with crystallographic surface orientations (001), (101), and (110) are investigated by using generalized spectroscopic ellipsometry. We report the complex anisotropic dielectric functions in the spectral range from 0.73 to 9.0 eV, for polarization along directions a, b, and c of the orthorhombic unit cell. A Kramers–Kronig consistent par
We investigate the temperature-dependent complex dielectric function of bulk single-crystal In2O3 over the spectral range of 1–6 eV and temperatures from room temperature to 600 °C under high-vacuum conditions using in situ spectroscopic ellipsometry. The dielectric function was modeled using wavelength-by-wavelength and critical-point model dielectric function analyses. The dielectric function ex
Begreppet adaptation to the adverse effects of climate change är relativt nytt in internationell miljörätt. Begreppet adaptation är inte definierat i UNFCCC. Den här uppsatsen analyserar adaptation i ljuset av begreppet reparation i internationell sedvanerätt. Uppsatsen undersöker vad begreppen adaptation och reparation har gemensamt. Kan adaptation i UNFCCC ses som en möjlig utveckling eller förlThe concept of adaptation to the adverse effects of climate change is relatively recent in international environmental law. Adaptation is not defined in the UNFCCC. This paper attempts to address adaptation in the UNFCCC from the perspective of reparation under customary international law. It investigates what the concepts of adaptation and reparation have in common. Could adaptation in the UNFCCC
Objective: This study assessed a national healthcare intervention launched in Sweden in 2015 to reduce the time between macroscopic haematuria, diagnosis and treatment of urinary tract cancer. Methods: The outcome of the first 11 months was evaluated in 1697 individuals referred to a standardized care pathway for urinary tract cancer compared with 174 patients with conventionally diagnosed urothel
