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Despite the crucial role of various insulin analogs in achieving satisfactory glycemic control, a comprehensive understanding of their in-solution dynamic mechanisms still holds the potential to further optimize rapid insulin analogs, thus significantly improving the well-being of individuals with Type 1 Diabetes. Here, we employed hydrogen-deuterium exchange mass spectrometry to decipher the mole
För att främja ett aktivt och hälsosamt åldrande (AHA) är det avgörande att förstå hur olika generationer använder digitala teknologier, då dessa verktyg blir en alltmer integrerad del av vardagen. Detta avhandlingsprojekt undersökte teknikanvändning bland kvinnor och män i tre åldersgrupper som representerar olika generationer (30–39, 50–59 och 70–79 år), med fokus på attityder, användningsmönsteTo promote active and healthy ageing (AHA), it is essential to understand how different generations engage with digital technologies, as these tools are becoming increasingly integral to everyday life. This thesis project explored technology adoption among men and women from three age groups representing different generations (30–39, 50–59 and 70–79 years), focusing on attitudes, usage patterns, a
BACKGROUND: Omentectomy has traditionally been performed in gastric cancer surgery, but omental preservation has become increasingly common. It is unclear whether omentectomy leads to additional survival benefit compared with omental preservation. This nationwide population-based cohort study aimed to assess survival and surgical outcomes comparing omental preservation to omentectomy in curative-i
In mouse early pachytene spermatocytes, the X and Y chromosomes undergo rapid non-homologous (NH) synapsis and desynapsis, but the functional significance remains unknown. Here, we report that pachynema-specific knockout of Speedy A (SpdyA) from telomeres caused persistent Y-X NH synapsis, with the entire Y axis synapsed onto the X axis. This persistent Y-X NH synapsis did not interrupt meiotic se
Naturvetenskap, teknik, ingenjörsvetenskap och matematik, på engelska ofta grupperade under akronymen STEM, är traditionellt mansdominerade områden. Särskilt inom ingenjörsvetenskap och teknologi är kvinnor fortfarande kraftigt underrepresenterade. Bristen på kvinnor inom STEM innebär utmaningar i att möta arbetsmarknadens behov, för produktkvalitet på grund av brist på olika perspektiv i designprScience, technology, engineering and mathematics, often grouped under the acronym STEM, are traditionally male dominated fields. Especially in engineering and technology, women continue to be heavily underrepresented. The lack of women in STEM poses challenges for meeting the labor market demands, for product quality due to a lack of diverse perspectives in the design process, and for gender equal
How we teach is strongly influenced by the culture we teach in, especially what (we believe) our colleagues think is good and acceptable. Understanding the reluctance to changes in teaching practice, including fear of disapproval from colleagues and students, investigating and reappraising those fears, and starting to talk about alternative interpretations is a first step towards overcoming the in
A novel concept of cold neutron source employing chessboard or staircase assemblies of high-aspect-ratio rectangular para-hydrogen moderators with well-developed and practically fully illuminated surfaces of the individual moderators is proposed. An analytic approach for calculating the brightness of para-hydrogen moderators is introduced. Because the brightness gain originates from a near-surface
BACKGROUND: Low back pain (LBP) is a leading cause of work absence globally. Digital interventions have the potential to increase access to self-management support for individuals with persistent LBP.OBJECTIVE: This study aims to evaluate the feasibility, usability, and acceptability of a digital educational program (MyRelief) designed to support self-management strategies for people with persiste
Over the last decade it has been pointed out by several philosophers that not all Status Function Declarations are synchronic: some such declarations are directed toward the absolute past. Such Status Function Declarations are perplexing if one is an ontic realist with respect to institutional properties and states of affairs. If successful, such Status Function Declarations seem to change the absOver the last decade it has been pointed out by several philosophers that not all Status Function Declarations are synchronic: some such declarations are directed toward the absolute past. Such Status Function Declarations are perplexing if one is an ontic realist with respect to institutional properties and states of affairs. If successful, such Status Function Declarations seem to change the abs
Introduction: Most cervical cancer cases in Sweden are diagnosed among women who have failed to attend screening. The objective of this study was to analyze the effectiveness of offering vaginal HPV (human papillomavirus) self-samples to long-term non-attendees as a routine in this screening program, in which non-attendees had already been the targets of several interventions. Material and Methods
Anxiety disorders are common in children and adolescents, but access to evidence-based treatment is limited. Most clinical guidelines recommend stratified care, where less complex patients are offered low intensity interventions and complex patients more intensive options. Stepped care, where all patients initially receive low-intensity treatment, has gained traction due to its potential cost-effe
Gamified virtual reality (VR) environments are increasingly used to enhance engagement and learning, yet most designs still adopt a one-size-fits-all approach that overlooks motivational diversity. The HEXAD framework, which classifies users into six player types, provides a promising lens for addressing this gap, but its predictive validity in immersive VR remains contested. This study investigat
Recent studies provide insights about local agency in regional development. While acknowledging non-local actors and drivers, these studies have not systematically discussed the link between extra-regional relations and local agency. This paper first discusses three key arguments in the literature on extra-regional relations covering context-specific dependencies, strategic coupling and open innov
The implementation of water-related environmental measures (WREMs) in agricultural businesses presents an opportunity to align food production with sustainable value creation through ecosystem services. However, the complexity of adopting these measures, and making them a part of business models, necessitates the involvement of intermediaries to facilitate business opportunities that align with go
Syftet med denna rapport är att belysa potentialen i offentlig upphandling, för att främja ett mer inkluderande och jämställt näringsliv, genom att stärka kvinnors företagande i Sverige. Offentlig upphandling är ett betydande verktyg för den offentliga sektorn, inte bara för att anskaffa varor, tjänster och entreprenader, utan också som ett potentiellt styrmedel för att uppnå samhällspolitiska mål
Background: Serially interconnected microfluidic devices enable advanced applications such as multi-step chemical processing and multi-organ-on-chip systems. However, managing these systems presents challenges due to interdependent fluid dynamics in their connecting channels, where even minor disturbances can propagate throughout the network, affecting overall system performance. Methods: This stu
BACKGROUNDDistinguishing wide complex tachycardia (WCT) as ventricular tachycardia (VT) or supraventricular WCT (SWCT) is critical yet challenging. Manual ECG algorithms require substantial expertise and are inconsistently applied, and contemporary computerized ECG interpretation (CEI) systems often return only a generic “wide complex tachycardia” label. Novel machine learning–based ECG models (So
Background: Available fluid biomarkers, neuroimaging techniques, and clinical assessments may enhance prediction of conversion to secondary progressive multiple sclerosis (SPMS). Objectives: : To identify robust real-world predictors of MS progression in the literature. Methods: : A systematic review was conducted in EMBASE. A total of 20,338 MS patients from 64 eligible studies were included. A p
