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Background: Sepsis is a leading cause of death worldwide and a major challenge for physicians to predict and manage. Proenkephalin A 119-159 (penKid) is a reliable surrogate marker for the more unstable endogenous opioid peptide enkephalin, which has previously been shown to predict both acute and chronic kidney disease. The aim of this prospective observational study was to assess penKid as a pre
We demonstrate the generation and in-situ measurement of the electric field and CEP of intense near-single-cycle laser pulses using the new optical technique of CEP dispersion-scan.
Here, we show a new diketopyrrole based polymeric hole-transport material (PBDTP-DTDPP, (poly[[2,5-bis(2-hexyldecyl)-2,3,5,6-tetrahydro-3,6-dioxopyrrolo[3,4-c]pyrrole-1,4-diyl]-alt-[[2,2′-(4,8-bis(4-ethylhexyl-1-phenyl)-benzo[1,2-b:4,5-b′]dithiophene)bis-thieno[3,2-b]thiophen]-5,5′-diyl]])) for application in perovskite solar cells. The material performance was tested in a solar cell with an optim
Background: Observational studies suggest an inequitable prescription of biologics in psoriasis care, which may be attributed to geographical differences in treatment access. Sweden regularly ranks high in international comparisons of equitable healthcare, and is, in connection with established national registries, an ideal country to investigate potential inequitable access. Objective: The aim wa
Objectives: We have observed clinical cases where bone is formed in the overlaying muscle covering surgically created bone defects treated with a hydroxyapatite/calcium sulphate biomaterial. Our objective was to investigate the osteoinductive potential of the biomaterial and to determine if growth factors secreted from local bone cells induce osteoblastic differentiation of muscle cells. Materials
Background: Mesenchymal stromal cells (MSCs) are currently being evaluated in numerous pre-clinical and clinical cell-based therapy studies. Furthermore, there is an increasing interest in exploring alternative uses of these cells in disease modelling, pharmaceutical screening, and regenerative medicine by applying reprogramming technologies. However, the limited availability of MSCs from various
Nutritional epidemiology is an inherently complex and multifaceted research area. Dietary intake is a complex exposure and is challenging to describe and assess, and links between diet, health, and disease are difficult to ascertain. Consequently, adequate reporting is necessary to facilitate comprehension, interpretation, and generalizability of results and conclusions. The STrengthening the Repo
Noncoding RNAs control critical cellular processes, although their contribution to disease remains largely unexplored. Dyskerin associates with hundreds of H/ACA small RNAs to generate a multitude of functionally distinct ribonucleoproteins (RNPs). The DKC1 gene, encoding dyskerin, is mutated in the multisystem disorder X-linked dyskeratosis congenita (X-DC). A central question is whether DKC1 mut
Objectives To describe the development, implementation and lessons learned of lifestyle intervention to promote appropriate gestational weight gain among Hispanic pregnant women. Design The intervention was informed by an empowerment oriented theoretical framework, and targeted women in the Pregnancy and Early Life Improvement Study. Methods The nutrition component consisted of recommendations for
Konvergensen är ett starkt sätt att skapa ökat kundvärde på befintliga eller nya produkter och tjänster. Detta adderande värde för kunden sker huvudsakligen på två nivåer av konvergensen.: Tjänstekonvergensen, där man genom att erbjuda tjänster såväl fast som mobilt ökar tjänsens värde och på så sätt ger kunden ett ökat värde. Det ökade värdet av tjänsterna grundar sig i att de kommer att vara til
This report is about the housing situation in Manila, capital of the Philippines. 25% of the inhabitants in this mega city live in informal settlements, often on places unsuitable for living. The target area of this paper is Baseco, a large slum area near the outlet of Pasig River and home to 47 000 people according to the 2002 census. Among its many problems including overpopulation and poverty i
In this report, methods for risk and vulnerability analysis of technological infrastructure and transport are examined. Fault Tree Analysis, Event Tree Analysis, and QRA can, along with Anticipatory Failure Determination, Hierarchical Holographic Modelling, and System Action Management, be used as methods for risk and vulnerability analysis of technical infrastructure. For risk and vulnerability a
Studiens syfte var att undersöka betydelsen av joint engagement för tre-fyraåringars prestation på false belief-testet Maxi. Joint engagement, som beskriver upplevelsen av att dela ett objekt eller händelse med någon annan, har i tidigare studier associerats med perspektivtagande. En testsituation designades där false belief-testet administrerades i form av en film om karaktären Maxi. Ett nytt tesThe aim of this study was to investigate the effect of joint engagement on three- to four year old children’s performance on the false belief-task Maxi. Joint engagement has been associated with perspective taking in previous studies and refers to the child’s and the adult’s mutual engagement in an object. The false belief-task in this study was designed as a film about the character Maxi. Another
The political participation of women is an important indicator of the degree of gender equality in certain country. In India, which is often referred to as the world’s largest democracy, the national parliament consists of only 11 % women. In a vast majority of India’s 28 states the female representation in their respective legislative assemblies is even less. However, when five states were holdin
Current trends show that the number of people affected by natural disasters is likely to increase in coming decades. Today, more than half the world's population lives in cities and the number is expected to rise in the future. To make cities safe is therefore vital. Making Cities Resilient is an ongoing global campaign in the area of disaster risk reduction and aims to build resilient cities
Shale gas extraction commonly known as fracking had support from the UK government with their ‘all out for shale’ policy. Despite this industry has struggled to establish itself mainly due to strong opposition from communities concerned about environmental and health impacts. Most research into the impacts of fracking is concerned with either environmental degradation or physical health impacts wh
