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Cytoreductive nephrectomy (CN) has been the standard of care in patients with metastatic clear-cell renal cancer who present with the tumour in place. The CARMENA trial compared systemic therapy alone with CN followed by systemic therapy. This article outlines the new guidelines based on these data. Patient summary: The CARMENA trial demonstrates that immediate cytoreductive nephrectomy should no
Over the past years, the installations of Shallow Geothermal Energy (SGE) systems are increasing throughout Europe, and it is indicating that a specific and detailed legal framework is necessary. Towards this direction, this paper consists of an overview of legislation issues on SGE at European level, based on concise reviews from fourteen countries, i.e., Croatia, Cyprus, France, Greece, Italy, L
A follow-up study of 12 patients who had undergone Stephens rectoplasty for high imperforate anus is presented. Clinical assessment and anal electromyography were performed more than 7 years after surgery, both before and after a year's physiotherapeutic training of the perianal musculature. Electromyography showed correlation between faecal continence and tonus of the anal sphincter, the anocutan
OBJECTIVE. Previous studies have shown the possibility to reduce radiation dose in abdominal CT by 25–50% without negatively affecting detection of liver lesions. How radiation dose reduction affects characterization of liver metastases is not as well known. The objective of this study was to investigate how different levels of simulated dose reduction affect the detection and characterization of
In butterflies, male reproductive success is highly related to the quality and the size of the spermatophore transferred to the female. The spermatophore is a capsule produced by the male during copulation, which in many species contains sperm in addition to a nuptial gift, and which is digested by the female after copulation. The nuptial gift may contribute to egg production and offspring quality
1. Outbreaks of herbivorous insects can have large impacts on regional soil carbon (C) storage and nutrient cycling. In northernmost Europe, population outbreaks of several geometrid moth species regularly cause large-scale defoliation in subarctic birch forests. An improved understanding is required of how leaf C and nutrients are processed after ingestion by herbivores and what this means for th
Objective: To study the impact of common noncomposite disease activity measures on sick leave in biologics-treated patients with rheumatoid arthritis (RA). Methods: Data from study visits by biologics-treated RA patients of working age (<65 years) in the observational South Swedish Arthritis Treatment Group Register between 2005 and 2011, were included (5,118 visits by 941 patients). We performed
Correct electrode placement - a prerequisite for correct ECG interpretation Different lead misplacements may present with typical ECG changes, which may influence the management of the patient, if not identified and corrected. It is important, both for the ECG technician and for the interpreting physician, to recognize typical patterns of lead misplacement to avoid misinterpretation of the ECG.
Volatile organic compounds (VOCs) in biological samples have gained popularity for disease monitoring and diagnosis. Celiac disease (CD) is one of the many prevalent health conditions which are challenging to diagnose. The aim of this study was to optimize a solid phase microextraction followed by gas chromatography-mass spectrometry, for quantitative analysis of a wide range of VOCs in the urine
Partially premixed combustion aims to reduce NOx and particulate matter emission without fuel consumption penalty. Low temperature heat release (LTHR) is an important process to be investigated. A novel motoring pressure prediction algorithm based on variable polytropic exponents was introduced and utilized to estimate average heat transfer coefficient as well as heat dissipation for real-time app
A search for charged Higgs bosons heavier than the top quark and decaying via H± → tb is presented. The data analysed corresponds to 36.1 fb−1 of pp collisions at s=13 TeV and was recorded with the ATLAS detector at the LHC in 2015 and 2016. The production of a charged Higgs boson in association with a top quark and a bottom quark, pp → tbH±, is explored in the mass range from mH± = 200 to 2000 Ge
Fragmin and heparin were studied in pigs during 120 min of cardiopulmonary bypass (CPB) and up to 240 min postoperatively, with respect to clotting, bleeding and the effects of protamine. Thirty-three pigs received bolus injections of 300 IU/kg with or without additional dosage during CPB and with or without subsequent protamine sulphate. Doses of Fragmin 60% higher were necessary to prevent clott
Solen är den primära källan för jordens klimatsystem, som driver den atmosfäriska och oceana cirkulationen. Förutom att solens varierande instrålning påverkan jordens klimat, så bestämmer instrålningen även den atmosfäriska produktionen av kosmogena partiklar (t. ex. 10Be, 14C, 36Cl) som sedan lagras i diverse klimatarkiv på jorden. Förändringar i solinstrålningen över tid kan därför undersökas ocThe Sun is the primary source for Earth’s climate system. Its fluctuations in irradiance are also known to have an impact on climate. In addition, changes in solar activity modulate the atmospheric production rates of cosmogenic radionuclides (e.g. 10Be, 14C, 36Cl) that all eventually deposit to different environmental archives. The signal of the changing solar activity through time can thus be re
Lactobacillus reuteri metabolizes glycerol through propanediol-utilization (Pdu) pathway to 1,3-propanediol (1,3-PD) via 3-hydroxypropionaldehyde (3-HPA) as intermediate. In the resting cells, the oxidized co-factor obtained in the reaction is regenerated by simultaneous oxidation of 3-HPA to 3-hydroxypropionic acid (3-HP) using propionaldehyde dehydrogenase (PduP), phosphotransacylase (PduL) and
