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INTRODUCTION: The ability to provide primary care with the help of a digital platform raises both opportunities and risks. While access to primary care improves, overuse of services and medication may occur. The use of digital care technologies is likely to continue to increase and evidence of its effects, costs and distributional impacts is needed to support policy-making. Since 2016, the number
Computed tomography (CT)-derived finite element (FE) models have been proposed as a tool to improve the current clinical assessment of osteoporosis and personalized hip fracture risk by providing an accurate estimate of femoral strength. However, this solution has two main drawbacks, namely: (i) 3D CT images are needed, whereas 2D dual-energy x-ray absorptiometry (DXA) images are more generally av
Proactive identification of chemicals with skin sensitizing properties is a key toxicological endpoint within chemical safety assessment, as required by legislation for registration of chemicals. In order to meet demands of increased animal welfare and facilitate increased testing efficiency also in nonregulatory settings, considerable efforts have been made to develop nonanimal approaches to repl
The Amazon rainforests and their biological diversity are being lost rapidly by the onslaught of extractive industries, large-scale agriculture and infrastructure development, which also undermines the integrity of indigenous territories and ethnicities, threatening the tremendous cultural diversity of the Amazon. The loss of forest, the disintegration of local communities and the increase of the
Powertrain efficiency is a critical factor in lowering fuel consumption and reducing the emission of greenhouse gases for an internal combustion engine. One method to increase the powertrain efficiency is to recover some of the wasted heat from the engine using a waste heat recovery system e.g. an organic Rankine cycle. Most waste heat recovery systems in use today for combustion engines use the w
Atmospheric inversions have been used for the past two decades to derive large-scale constraints on the sources and sinks of CO2 into the atmosphere. The development of dense in situ surface observation networks, such as ICOS in Europe, enables in theory inversions at a resolution close to the country scale in Europe. This has led to the development of many regional inversion systems capable of as
This paper presents a thorough manufacturing cost analysis for a powder metallurgy (PM) manufactured gear (using press and sintering technique—P/S), through a case study of a R&D 4th drive gear (a helical gearwheel) utilizing both real usage data from six companies and some estimated data from literatures. The chosen costs calculation method, performance part costing (PPC), is comprehensive an
A search is presented for four-top-quark production using an integrated luminosity of 139 fb- 1 of proton–proton collision data at a centre-of-mass energy of 13TeV collected by the ATLAS detector at the LHC. Events are selected if they contain a same-sign lepton pair or at least three leptons (electrons or muons). Jet multiplicity, jet flavour and event kinematics are used to separate signal from
In this study we illuminate and discuss the most recent developments in respect of the interpretation of the “industrial application” requirement with respect to gene and protein related inventions in Europe. The analysis will focus on the relevant provisions of the EPC and decisional practice from the European Patent Organisation (“EPO”), particularly decisions from the Technical Board of Appeal
Background. Efforts to identify specific variables that impact most on outcomes from interdisciplinary pain rehabilitation are challenged by the complexity of chronic pain. Methods to manage this complexity are needed. The purpose of the study was to determine the network structure entailed in a set of self-reported variables, examine change, and look at potential predictors of outcome, from a net
The four major satellites of Jupiter, known as the Galilean moons, and Saturn's most massive satellite, Titan, are believed to have formed in a predominantly gaseous circum-planetary disk during the last stages of formation of their parent planet. Pebbles from the protoplanetary disk are blocked from flowing into the circumplanetary disk by the positive pressure gradient at the outer edge of the p
Gene therapy to treat pharmacoresistant temporal lobe epilepsy in humans is now being developed using an AAV vector (CG01) that encodes the combination of neuropeptide Y and its antiepileptic receptor Y2. With this in mind, the present study aimed to provide important preclinical data on the effects of CG01 on the duration of transgene expression, cellular tropism, and potential side effects on bo
The humoral immune response to autologous leukemic cells was investigated in childhood ALL using a 125I protein A binding assay. In 5/7 patients antibodies were demonstrated at diagnosis and in 3/7 cases also after chemotherapy. Sera from 2/3 patients, which bound significantly to autologous leukemic cells, did not bind significantly to autologous remission cells. In allogeneic experiments sera bo
We report large-scale estimates of Amazonian gap dynamics using a novel approach with large datasets of airborne light detection and ranging (lidar), including five multi-temporal and 610 single-date lidar datasets. Specifically, we (1) compared the fixed height and relative height methods for gap delineation and established a relationship between static and dynamic gaps (newly created gaps); (2)
Purpose: To evaluate the outcome of referrals for suspected glaucoma based on elevated intraocular pressure (IOP) made by optometric practitioners in Sweden. Methods: This prospective study included 95 individuals referred to the Skåne University Hospital Malmö, Sweden, during 2019, by optometric practitioners, based on elevated IOP. Positive outcome was defined as a diagnosis of glaucoma, or a di
A search is presented for new phenomena in events characterised by high jet multiplicity, no leptons (electrons or muons), and four or more jets originating from the fragmentation of b-quarks (b-jets). The search uses 139fb-1 of s = 13 TeV proton–proton collision data collected by the ATLAS experiment at the Large Hadron Collider during Run 2. The dominant Standard Model background originates from
Laser-based fabrication of metal-halide perovskite mini-modules has recently been demonstrated using nanosecond (ns) laser pulses. However, it still suffers from high-resistance contacts due to remaining PbI2 residues at the bottom of the absorber-opening P2 scribe line. Therefore, in this study, we investigate the effect of shorter picosecond (ps) laser pulses, and thus lower heat input, on the c
