Filetype
Introduction: Mycobacteria have a unique hydrophobic membrane with several lipid-enriched layers that are low in permeability, setting them apart from other bacteria. This complex structure, consisting of three distinct layers is crucial for cell growth, virulence, and providing a barrier to antibiotics. Previously, we identified a plectasin variant, NZX, which showed activity against Mycobacteriu
BACKGROUND: Chronic obstructive pulmonary disease (COPD) has many known dysregulated inflammatory proteins. A disintegrin and metalloproteinase 17 (ADAM17) is a protease that sheds several proteins involved in COPD pathogenesis. The aim was to investigate ADAM17, its phosphorylated form (pADAM17) and its substrates in bronchoalveolar lavage (BAL) and blood from COPD and control subjects. METHODS:
Globally, road traffic accidents (RTAs) remain a major cause of death, particularly among individuals aged 15–30 years. While Sweden has been at the forefront of traffic safety through the Vision Zero initiative, in-hospital management remains crucial in determining RTA outcomes. Drawing on North American evidence suggesting improved survival at trauma centres, the Swedish healthcare system has in
Supersolids formed from dipolar Bose Einstein condensates (BECs) exhibit spontaneous density modulation while maintaining global phase coherence. This state of matter supports gapped amplitude (Higgs) excitations featuring a quadratic dispersion relation. While Higgs modes are typically strongly damped due to coupling with other amplitude and phase modes, imposing an experimentally realistic toroi
ISSUES: Although alcohol consumption is linked to atrial fibrillation (AF), the relationship across different intake levels and between sexes remains unclear. This study presents the first network meta-analysis of prospective cohort studies bringing greater precision to these associations.APPROACH: A systematic review identified five meta-analyses on alcohol and AF risk. From these, 13 cohort stud
Epilepsy is a prevalent neurological disorder characterized by spontaneous recurrent seizures (SRS). Epileptogenesis is a multifaceted pathophysiological process that transforms a normal brain into one prone to chronic seizures. Targeting epileptogenesis is a compelling line of epilepsy therapy. Thus, discovering new drugs that oppose, mitigate, or modify epileptogenesis is a significant challenge
Aims/hypothesis: The aim of this work was to investigate whether baseline uric acid (UA) is associated with future complications among young individuals with newly diagnosed type 1 diabetes. Methods: UA levels were analysed in individuals, aged 15–34 years with newly diagnosed type 1 diabetes, from the nationwide Diabetes Incidence Study in Sweden (DISS) cohort to assess the relationship with macr
The twin transition, which combines green and digital innovation in economic activities, is increasingly central to policy agendas and is also receiving growing attention in regional research. However, accurately mapping green, digital and twin (both green and digital) economic activities across regions remains challenging, particularly due to data constraints. In this study, we advance this resea
Stiffening of tissue is a hallmark of cancer progression, promoting invasive phenotypes through altered cell-extracellular matrix (ECM) interactions. However, how fully formed epithelial structures respond to mechanical cues within their native ECM environment remains poorly understood. Here, using a 3D in situ stiffening hydrogel system that enables modulation of stiffness around mature normal ma
A classical state-preparation device cannot generate states in relative superposition. We introduce classical models in which devices that are individually unable to generate states with relative superposition can be stochastically coordinated to simulate sets of quantum states. These models have natural operational interpretation in prepare-and-measure scenarios and they can account for many non-
Ultracold quantum gases with long-range anisotropic interactions host novel exotic phases of matter, such as supersolids, exhibiting both rigid and superfluid characteristics. The impact of this interplay on the out-of-equilibrium dynamics of dipolar gases, and in particular its connection with universal turbulent behavior, remains highly unexplored. Here, upon considering a dipolar Bose-Einstein
The growing challenge of antibiotic resistance calls for alternative therapeutic strategies beyond conventional antibiotics. Antibacterial Photodynamic Therapy (aPDT), based on the light-induced generation of Reactive Oxygen Species (ROS), offers a non-specific approach that is detrimental to bacterial cells at multiple levels. Here, we explore the photocatalytic properties of nitrogen-doped titan
Professor Contact details Email: ulf [dot] gerdtham [at] med [dot] lu [dot] se Phone: +46 46 222 48 10 Mobile: +46 76 887 12 04Organisation Health Economics Room number: alfa 4005, BMC E15 WebpageUlf Gerdthams profile in Lund University research portalPersonal website:https://sites.google.com/site/ulfgerdtam/Other affiliations Research team manager Health Economics Professor Department of Economic
https://www.lusem.lu.se/ulf-gerdtham - 2026-07-24
Further characterization of the post-cardiac arrest syndrome (PCAS) is essential to better understand the mechanisms resulting in injury and death. We investigated serial serum concentrations of the stress hormone c-terminal provasopressin (CT-proAVP or copeptin), the cardiac biomarker MR-proANP and a biomarker of oxidation injury, Peroxiredoxin 4 (Prx4) in patients treated with mild hypothermia (
Merkel cell carcinoma (MCC) is a rare type of skin cancer that has a characteristically increased incidence among immunosuppressed subjects. The DNA of Merkel cell polyomavirus (MCV) is regularly found in most MCC tumors. We investigated whether Merkel cell polyomavirus (MCV) infection increases the risk for future Merkel cell carcinoma (MCC). Two large biobank cohorts (Southern Sweden Microbiolog
OBJECTIVETo investigate associations of maternal gestational weight gain and body composition and their impact on offspring body composition and adipocytokine, glucose, and insulin concentrations at age 4 months.RESEARCH DESIGN AND METHODSThis was a prospective study including 31 mother-infant pairs (N = 62). Maternal body composition was assessed using doubly labeled water. Infant body compositio
Reliable and effective verification of soil carbon sequestration is required for quantification of project-based greenhouse gas mitigation. Direct soil sampling is necessary for measurements at field level. In this study, soil samples from a semiarid agroecosystem of the Sudan were statistically analyzed to evaluate if changes in soil organic carbon (SOC) over time or space were detectable or not,
Objectives: The aim of the study was to assess whether bone mass and metabolism are impaired in genetically at-risk children with screening-detected celiac disease. Methods: Included were 71 children with screening-detected celiac disease diagnosed at 10.0 ± 0.7 (mean ± standard deviation) years and 142 matched controls and 30 children with screening-detected celiac disease diagnosed at 3.3 ± 0.4
