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User generated content (UGC) makes up a significant portion of Internet traffic. As opposed to other content, UGC has so far been left outside over-the-top providing network operators content distribution networks (telco-CDN) due to the difficulty in determining optimised placement of such content. The side effect of this is that UGC content is not placed close to end users and therefore occupy un
Lipid nanoparticles (LNPs) are clinically approved for mRNA-based vaccines and liver-targeted siRNA delivery. However, poor nucleic acid delivery efficiency limits their application in extrahepatic tissues and tumors. Here, using live-cell and super-resolution microscopy, we identify multiple distinct steps of inefficiencies in the cytosolic delivery of both siRNA and mRNA cargoes. Membrane damage
Below you will find information regarding how to receive letters or larger parcels. Receive a letter or parcelPostcards and letters will be delivered to the recipient's letterbox. Parcels too large to fit in the letterbox, will need to be picked up at a "postombud", which is a grocery store or corner store that has been selected to provide postal services.When a parcel too large to fit the letterb
https://www.luaccommodation.lu.se/student-accommodation/moving/receiving-letters-and-parcels - 2026-06-23
Vi studerar blod- och immunsystemet och dess sjukdomar. Ett särskilt fokusområde är hur medfödd genetisk variation påverkar hur blod- och immunceller, och hur sådan variation kan utnyttjas kliniskt. Vilka gener och genmutationer styr t ex risken för blodcancer? Kan vi utnyttja dem för att förebygga och behandla? Vilka styr vår blodgruppsuppsättning? Kan vi utnyttja dem för säkrare transfusion? EttWe study the blood and immune system and its diseases. A particular focus area is how congenital genetic variation affects blood and immune cells, and how such variation can be utilized clinically. Which genes and gene mutations control, for example, the risk of blood cancer? Can we use them to prevent and treat? Who controls our blood group set? Can we use them for safer transfusion? Another impo
Poverty has a long history in Africa. Yet, the most conventional and influential history of African poverty is a very short one. As told by the World Bank, the history of poverty starts in the 1980s with the first Living Standard Measurement Study. This history of poverty by numbers is also a very narrow one. There is a disconnect between the theoretical and historical underpinnings of how academi
In this article we address the problem of projective reconstruction of structure and motion given only image data. In particular we investigate three novel minimal combinations of points and lines over three views, and give complete solutions and reconstruction methods for two of these cases: 'four points and three lines in three views', and 'two points and six lines in three views'. We show that
Incomplete lysosomal acidification in microglia inhibits the degradation of fibrillar forms of Alzheimer's amyloid β peptide (fAβ). Here we show that in primary microglia a chloride transporter, ClC-7, is not delivered efficiently to lysosomes, causing incomplete lysosomal acidification. ClC-7 protein is synthesized by microglia but it is mistargeted and appears to be degraded by an endoplasmic re
On this page, you will learn how to create and submit an exchange application in the SoleMove application system. Before you start your applicationThere are a few things you need to think about before you start your application, depending partly on whether you will be spending a semester or a full academic year (two semesters) at Lund University. Exchange studies are full-time studies As an exchan
Att insjukna i en reumatisk ledsjukdom innebär betydande förändringar i livet, särskilt när det sker under barndomen eller ungdomen. Vår forskning omfattar flera reumatiska och inflammatoriska tillstånd, med särskilt fokus på juvenil idiopatisk artrit (JIA), men även andra sjukdomar som Kawasakis sjukdom och MIS-C (hyperinflammation efter COVID-19-infektion). Vi bedriver både klinisk- och laboratoBeing diagnosed with a rheumatic disease entails significant life changes, especially when it occurs during childhood or adolescence. Our research encompasses several rheumatic and inflammatory conditions, with a particular focus on juvenile idiopathic arthritis (JIA), but also other diseases such as Kawasaki's disease and MIS-C (hyperinflammation following COVID-19 infection). We conduct both cli
Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC-epsilon in Fcgamma receptor (FcgammaR)-dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP m
Early Warning Systems (EWS) are crucial for safeguarding communities, but are vulnerable to failure due to a technocratic focus that excludes local communities. This thesis closes the gap between normative participatory principles and practical implementation by exploring the entry points or challenges that affect community participation. Adopting a complexity theory lens, the study conducts a qua
Flera forskningsprojekt vid vår avdelning är inriktade på att bättre förstå mekanismer som ligger bakom utvecklingen av svåra infektionssjukdomar, fr.a. orsakade av bakterier men också av virus och svampar. Utgångspunkten för arbetet har ofta varit upptäckten av bakteriella ytproteiner och enzymer som på olika sätt interagerar med människans försvarssystem (medfödd och förvärvad immunitet och blodSeveral research projects at our Division are focused on molecular and cellular mechanisms that contribute to the development of severe infections caused preferentially by bacteria, but also by viruses and fungi. The starting point for this work has often been the discovery of bacterial surface proteins and enzymes that interact with human defenses (innate and acquired immunity and blood coagulati
Although many therapeutically active peptides and proteins have been developed there is a lack of topical pharmaceutical products on the market containing these sensitive molecules. The main reasons may be lack of stability and a limitation of larger molecules to penetrate into the skin. In this study we investigated the possibility to develop a peptide formulation which enables follicular permeat
There is compelling evidence that more diverse ecosystems deliver greater benefits to people, and these ecosystem services have become a key argument for biodiversity conservation. However, it is unclear how much biodiversity is needed to deliver ecosystem services in a cost-effective way. Here we show that, while the contribution of wild bees to crop production is significant, service delivery is
