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Polycrystalline diamond (PCD) is currently under development as a new generation of cutting tool material for titanium alloy machining applications. The unrivaled high temperature hardness possessed by PCD offers the potential for higher levels of productivity compared to tungsten carbide, the current industry standard tool material, through facilitating higher cutting speeds. This study investiga
Dihydropyrimidinase (DHPase) is a key enzyme in the pyrimidine pathway, the catabolic route for synthesis of β-amino acids. It catalyses the reversible conversion of 5,6-dihydrouracil (DHU) or 5,6-dihydrothymine (DHT) to the corresponding N-carbamoyl-β-amino acids. This enzyme has the potential to be used as a tool in the production of β-amino acids. Here, the reaction mechanism and origin of ster
The role of time-dependent freezing of ice nucleating particles (INPs) is evaluated with the “Aerosol–Cloud” (AC) model in 1) deep convection observed over Oklahoma during the Midlatitude Continental Convective Cloud Experiment (MC3E), 2) orographic clouds observed over North California during the Atmospheric Radiation Measurement (ARM) Cloud Aerosol Precipitation Experiment (ACAPEX), and 3) super
BACKGROUND: The St Gallen 2019 guidelines for primary therapy of early breast cancer recommend omission of completion axillary lymph node dissection (cALND), regardless of histological type, in patients with one or two sentinel lymph node (SLN) metastases. Concurrently, adjuvant chemotherapy is endorsed for luminal A-like disease with four or more axillary lymph node (ALN) metastases. The aim of t
Context. The light curves of tidally locked hot Jupiters transiting fast-rotating, early-type stars are a rich source of information about both the planet and star, with full-phase coverage enabling a detailed atmospheric characterisation of the planet. Although it is possible to determine the true spin-orbit angle ψ-a notoriously difficult parameter to measure-from any transit asymmetry resulting
Due to limited groundwater resources in arid and semi-arid areas, conjunctive use of surface water and groundwater is becoming increasingly important. In view of this, there are needs to improve the methods for conjunctive use of surface and groundwater. Using numerical models, optimization algorithms, and machine learning, we created a new comprehensive methodological structure for optimal alloca
The electronic excitation spectra of pyridine and phosphabenzene have been studied using theoretical methods. The electronic states are described by wave functions derived from second-order perturbation theory based on multiconfigurational reference functions. The study includes singlet and triplet valences excited states as well as a number of Rydberg states. For both molecules the transitio
The relationship between gender and mortality in nineteenth-century Europe has been highly debated. In particular, historians disagree about the manner and degree to which gender discrimination affected the mortality risk of the female population. This article contributes by examining the evidence of gendered mortality differences among children and adolescents in nineteenth-century Denmark. It ma
The transport and oxidation of glucose, the content of fructose 1,6-diphosphate, and the release of insulin were studied in microdissected pancreatic islets of ob/ob mice incubated in Krebs-Ringer bicarbonate medium. Under control conditions glucose oxidation and insulin release showed a similar dependence on glucose concentration with the steepest slope in the range 5-12mm. The omission of Ca(2+)
β-1,4-Galactosyltransferase 7 (β4GalT7) is a key enzyme in the synthesis of two classes of glycosaminoglycans (GAG), i.e., heparan sulfate (HS) and chondroitin/dermatan sulfate (CS/DS). GAG chains are linear polysaccharides of alternating hexuronic acid and N-acetylhexosamine residues, commonly linked to core proteins to form proteoglycans with important roles in the regulation of a range of biolo
Acylation of 1D-myo-inositol 1,2,6-trisphosphate (α-trinositol) followed by alkylation of the phosphate groups with benzyl bromoacetate or 2-benzyloxyethyl iodide and deprotection provides a route to analogues with modified phosphate groups. The modifications made alter steric and ionisation properties but the possibility to participate in hydrogen bonding and ionic interaction is retained.
This cross-country study investigates the potential to improve pig welfare by exploiting consumer demand, domestically and in export markets, for welfare pork produced in indoor production systems. The analysis is based on questionnaire data collected in 2019 focusing on demand for Danish welfare pork both in Denmark and in two nearby export markets, Sweden and Germany. To reduce hypothetical biasThis cross-country study investigates the potential to improve pig welfare by exploiting consumer demand, domestically and in export markets, for welfare pork produced in indoor production systems. The analysis is based on questionnaire data collected in 2019 focusing on demand for Danish welfare pork both in Denmark and in two nearby export markets, Sweden and Germany. To reduce hypothetical bias
BACKGROUND: Meal-induced metabolic changes trigger an acute inflammatory response, contributing to chronic inflammation and associated diseases. OBJECTIVES: We aimed to characterize variability in postprandial inflammatory responses using traditional (IL-6) and novel [glycoprotein acetylation (GlycA)] biomarkers of inflammation and dissect their biological determinants with a focus on postprandial
Weather conditions affect animals in many different ways. Variation in temperature, rainfall, wind, and other environmental variables can have an impact at a range of temporal and spatial scales and at every level from individual behavior to species distributions. The interactions between these variables may be particularly important but are often overlooked. Hence, understanding how animals respo
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Prostate-specific antigen (PSA) and human glandular kallikrein 1 (hGK-1) are structurally similar products of the human glandular kallikrein gene locus on chromosome 19 that become selectively expressed by human prostate tissue. PSA is one of the most abundant prostate-derived proteins in the seminal fluid. The mature form of PSA, a single-chain glycoprotein of 237 amino acids, is a serine proteas
The structural and dielectric properties of gadolinium oxide (Gd2O3) grown on Si(001) depending on the epitaxial growth conditions were investigated. Gd2O3 layers were grown at temperatures between 250 °C and 400 °C with an oxygen partial pressure between 2 x 10-7 mbar and 5 x10-7 mbar. The crystal structure of the Gd2O3 turns out to be monoclinic with rotational domains as revealed by x-ray diffr
