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The lack of research on why certain locations are perceived as unsafe has often been attributed to the scarcity of suitable data on place-based fear of crime. To address this gap, this study explores two spatial data collection methods applied in semi-rural areas of Kristianstad, Sweden. The first method uses a digital sketch map integrated with open-ended questions, accessed via an online web map
Functional p53 protein is essential for the cellular response to drug-induced DNA damage. We investigated p53 accumulation in tumour specimens from premenopausal breast cancer patients who were randomised to adjuvant chemotherapy (CMF) or postoperative radiotherapy. Of the tumours from 139 patients, 20 showed abnormal accumulation as judged with immunohistochemistry (> 10% positive tumour cells).
Abstract – Introduction: – Spinal disorders are among the biggest contributors to health care utilization (HCU).Objective: – To develop and externally validate a prediction model for high all-cause HCU (75th percentile during 1 year after the index date) among patients with spinal disorders visiting multidisciplinary secondary care clinics.Methods: – We developed and internally validated the model
Background: Tick-borne encephalitis (TBE) is a serious vector-borne neurological disease in Europe, with a complex transmission cycle involving ticks of genus Ixodes, animal hosts, environmental and climatic determinants. Methods: We modelled annual Geocoded Swedish TBE case data for the period 2005–2023 as a log-Gaussian Cox process in relation to population, environmental and climate data, and w
Bridges are critical assets within transportation networks, and their failure, whether due to accidental actions, extreme environmental events, or localized damage, can lead to consequences that extend far beyond the structure itself. In addition to direct safety implications, bridge failures often result in prolonged traffic disruption, economic losses, and reduced network resilience. As traffic
The urgency of addressing climate change has underscored the need for precise carbon management—an approach that precisely monitors, assesses, and manages carbon emissions and sequestration at fine spatial, temporal, and sectoral scales. This perspective paper examines the current state of precise carbon management, highlighting advancements in ground-based observations, remote sensing, process-ba
Globalized economics have resulted in intricate global value chains carrying systemic risks of adverse human rights impacts. To address this, the EU adopted the Corporate Sustainability Due Diligence Directive (CSDDD) in June 2024, establishing mandatory human rights due diligence for covered companies. However, following a regulatory simplification agenda aimed at reducing corporate administrativ
Urban pluvial flooding threatens transport accessibility, yet the spatial factors such as elevation, vegetation, and road density associated with accessibility loss remain insufficiently understood. This study assessed changes in nearest-facility travel time to hospitals, clinics, schools, supermarkets, and fire stations under a 100-year return period flood scenario in Stockholm, Sweden, for both
Urocanate reductase (UrdA) is a bacterial enzyme that converts urocanic acid to imidazole propionate. Its catalytic residue Arg411 undergoes a large conformational change in the substrate-bound versus product-bound states. In contrast to previously studied cryo-conditions, the room-temperature X-ray data of UrdA presented here show that the occupancy distribution of Arg411 is affected by crystal c
Background: Cardiac allograft vasculopathy (CAV) is one of the major long-term complications in patients after heart transplantation (HTx) limiting allograft function and longevity. CAV can be studied non-invasively by evaluating myocardial perfusion (MP). Aspirin is re--ed after Htx, but it is unclear whether it affects the development of CAV. The aim of this study was to investigate the associat
Background/Objectives: The surgeon’s subjective intraoperative evaluation is the standard of care to assess postoperative residual disease (RD) in advanced epithelial ovarian cancer (EOC). We investigated the feasibility of ctDNA as an objective marker for postoperative RD. Methods: This prospective study included 27 patients with advanced ovarian cancer (FIGO IIIA1–IVB) who underwent primary surg
This paper deals with the home-leaving of young adults in Gothenburg, Sweden, in the period 1915–1943. We used individual-level panel data from population registers and poll-tax records, taking a competing risk design for the analysis of the determinants of leaving home to marry, or for non-familial living. We found a transitional, marriage-driven pattern of leaving home that neither fits the old
Hydrological modelling is essential for effective water resources management, as it represents complex physical processes through mathematical equations to improve our understanding of the water cycle. FLEXG is a glacio-hydrological model that has been successfully applied and found to perform well in glacierized regions. This study seeks to improve the capability of classical FLEXG model for glac
This study utilizes advanced 3D imaging techniques, combining X-ray and neutron tomography, to investigate the hydromechanical evolution of Idaho Gray sandstone during coupled triaxial permeability tests. The analysis involved correlating mechanical and hydraulic bulk measurements, porosity fields, strain fields derived from Digital Volume Correlation analysis and fluid speed fields derived from t
Control of the microstructure of steel components during their processing is a crucial factor for reaching desired product properties. Realistic simulations of the microstructure evolution during processing can facilitate the improvement of existing processes as well as the design of new ones by reducing the need for time- and cost-intensive experimental investigations. This work focuses on the mo
The tyrosine residue in amyloid-β (Aβ) is susceptible to attack by various reactive nitrogen intermediates, leading to the formation of 3-nitrotyrosine (3-NT), a post-translational modification associated with the pathophysiology of Alzheimer's disease (AD). Although considered a “dead-end” product, emerging evidence suggests that 3-NT can be reduced to 3-aminotyrosine (3-AT) in vivo. This study a
Current trends aim at improving the surface integrity of aerospace Ni-based superalloys by reducing the temperature rise in the cutting zone in order to minimize tool wear, as well as reducing the thermally induced tensile residual stresses on the machined surface. The manufacturing industry is also driven by developing high performance sustainable machining processes. Cryogenic machining (CM) usi
