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Abstract in Undetermined Background: Measured or modeled levels of outdoor air pollution are being used as proxies for individual exposure in a growing number of epidemiological studies. We studied the accuracy of such approaches, in comparison with measured individual levels, and also combined modeled levels for each subject's workplace with the levels at their residence to investigate the influe
Assessment of health-related quality of life (HRQoL) in haemophilia is important in order to provide information for clinical decision making and to verify the impact of haemophilia on patients and their families. Advances in haemophilia care and prophylactic treatment have improved HRQoL for the patients and where treatment is available, patients with haemophilia have almost reached the same life
Popular Abstract in Swedish Endokrina och metabola sjukdomstillstånd har många gemensamma komponenter. Att förstå de signalvägar som ligger till grund för dessa sjukdomar hjälper oss att utveckla bättre behandlingsmetoder. Det övergripande syftet med min forskning är att undersöka den roll s.k. G-protein kopplade receptorer spelar i endokrina metaboliska sjukdomar, mer specifikt de signalvägar somThe aims of this dissertation were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) throug
Climate change will alter the hydrological cycle in the 21st century with implications for the water balance and water quality. As characteristics of the landscape may vary significantly between nearby locations, hydrological models need to be able to delineate responses attributed to specific landscape characteristics, to estimate their responses to altered climatic drivers. Small streams are the
This experimental study investigates how individual variation in cognitive functioning, specifically working memory, previous experience with language learning but also language background, influence language aptitude, in particular grammatical inferencing - the capacity to spot patterns in grammar - as measured by the LLAMA_F test. Firstly, the study explores individual factors hypothesised to in
Particle size can be an important variable to know in many different areas, be it smoke simulations, toxicity of materials or tests of face masks. Fires in a reduced oxygen environment can occur for ventilation-controlled fires or in areas with artificially lowered oxygen levels. The effects of lower concentrations of oxygen on heat release rate, smoke production etc. has been studied, but any eff
Generella skatteflyktsregler, eller GAARs (general anti-avoidance rules), är legislativa åtgärder mot skatteflykt. GAARs typiska struktur består av två förutsättningar: skattebetalarens syfte och lagstiftarens syfte. Om det huvudsakliga syftet med en transaktion är att minimera skatteutgifter på ett sätt som lagstiftaren inte hade avsett får transaktionen bortses ifrån vid beskattningen. GAARs potGeneral anti-avoidance rules, or GAARs, are legislative measures against unacceptable tax avoidance. The typical structure of a GAAR refers to two prerequisites: the intent of the taxpayer and the intent of the legislator. If the main purpose of a transaction is to minimize tax expenses in a way unintended by the legislator, the transaction can be disregarded from a tax perspective. The potentiall
This thesis is a comparative legal research of the enforcement of maritime claims in two countries of the Baltic sea region - Russia and Latvia. It focuses on substantive and procedural aspects of enforcement of maritime claims. Thorough analysis of the ship arrest possibilities provided under Russian and Latvian law and of encumbrances of maritime property (maritime liens and ship mortgages) is s
Uppsatsen utforskar vad som händer med ett narrativ som World of Warcraft när det återges i andra former än i dess ursprungliga medium. En problemställning som uppsatsen undersöker är vilka delar av ett narrativ som följer med från den ursprungliga medieformen och hur det sker. I studiens fall innebär det vilka delar eller aspekter av online-spelet World of Warcrafts narrativ som återskapas i tidn
Pritam Kumarsingh A Case Study to develop and test GIS/SDSS methods to assess the production capacity of a Cocoa Site in Trinidad and Tobago Trinidad and Tobago has achieved world-wide affirmation for its unique fine and flavour cocoa (Theobroma cacao). This classification of cocoa commands price premiums on the global market. However, the industry has declined over years. Investors and farmers
In the central Himalayas, water dynamics are expected to change due to multiple factors like climate change, hydro power development and shifting land use practices. This thesis looks at possible changes in water dynamics in Marsyandi river basin, Nepal, as well as causes to those changes and how they are perceived locally. Grounded in critical physical geography, the study uses mixed methods an
Fully precise static analysis of program behavior is undecidable in theory and infeasible in practice. While individual static analyses can prove specialized invariants about program behavior or resolve narrow ambiguities, real programs are complex composites of many different abstractions and programming patterns. State-of-the-art approaches to program analysis thus generally rely on composite an
BACKGROUND: This study aimed to evaluate the prevalence of pathogenic/likely pathogenic cardiomyopathy variant carriers in a multiancestry US population and examine the risk of adverse clinical outcomes. METHODS: This retrospective cohort study included multiancestry US adults aged ≥18 years with sequencing data from the All of Us Research Program. Pathogenic/likely pathogenic variants in cardiomy
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and cardiac transplantation. We report a genome-wide association study and multi-trait analysis of DCM (14,256 cases) and three left ventricular traits (36,203 UK Biobank participants). We identified 80 genomic risk loci and prioritized 62 putative effector genes, including several with rare variant DCM associations (MAP3K7, NEDD4L a
Instructions for First and Second-Cycle Syllabi Approved by the Faculty Board’s working committee on 11 December 2024 Valid from 13 January 2025 Reg. no STYR 2024/2625 Contents Introduction.......................................................................................................................... 2 Working process and authorisation in Lubas ...........................................
This chapter deals with the need to intentionally support staff in developing evidence-based skills. While formal teaching has a place, most activity will be mentor based. We present a suggested minimum skill set and discuss ways of maintaining developments.
This paper compares two flow routing algorithms' influences on ecohydrological estimations in a northern peatland catchment, within the framework of an arctic-enabled version of the dynamic ecosystem model LPJ-GUESS. Accurate hydrological estimations are needed to fully capture vegetation dynamics and carbon fluxes in the subarctic peatland enviroment. A previously proposed distributed hydrologica
Background: Neutrophil gelatinase-associated lipocalin (NGAL) has been suggested as the most promising biomarker of acute kidney injury. However, there are no reliable data on analytical sensitivity and reference limits of urinary NGAL (uNGAL) assay in pediatric age. The aim of the present study is to evaluate the analytical sensitivity and the reference range of uNGAL measured in urine specimens
