Search results

Recombinant amorpha-4,11-diene synthase from Artemisia annua, expressed in Escherichia coli, was incubated with the deuterium-labeled farnesyl diphosphates, (1R)-[1-H-2]FPP, (1S)-[1-H-2]FPP, and [1,1-H-2(2)]FPP. GC-MS analysis of amorpha-4,11-diene formed from the deuterated FPPs shows that the deuterium atoms are retained in the product. Furthermore, analysis of the MS-spectra obtained with the d

A blend of rapeseed and butter oil was transesterified using immobilized Thermomyces lanuginosus lipase (Lipozyme (R) TL IM) as catalyst. The reaction was followed by reversed-phase HPLC and the triacylglycerol peaks were tentatively identified from their elution times by calculating equivalent carbon numbers. Further identification was made using HPLC-electrospray tandem mass spectrometry. A few

Leflunomide is a low molecular weight immunosuppressive drug which inhibits the enzymes dehydroorotate dehydrogenase and protein tyrosine kinase, both of which are important components in the immune response. As the mechanisms of action of leflunomide and tacrolimus are different, we postulated an additive or synergistic effect of the two drugs and investigated the effects of leflunomide alone, or

Objective: To assess overall resource consumption, work capacity and quality of life of patients with multiple sclerosis in nine European countries. Methods: Information on resource consumption related to multiple sclerosis, informal care by relatives, productivity losses and overall quality of life (utility) was collected with a standardised pre-tested questionnaire from 13186 patients enrolled i

This paper reports speech articulator gestures in Swedish, Bulgarian, and Greenlandic to study universal and language-specific components in articulation. This work is based on analysis of movements of individual articulators from x-ray motion films of speech, and continues from previous reports from this study by Wood [J. Phon. 7, 25–43 (1979); 19, 281–292 (1991); Proc. 3rd Conf. I.C.P.L.A., 191–

We analyzed 34 cases of urothelial carcinomas by miRNA, mRNA and genomic profiling. Unsupervised hierarchical clustering using expression information for 300 miRNAs produced 3 major clusters of tumors corresponding to Ta, T1 and T2-T3 tumors, respectively. A subsequent SAM analysis identified 51 miRNAs that discriminated the 3 pathological subtypes. A score based on the expression levels of the 51

Populärkulturen spelar en viktig roll i att forma föreställningar om romantiska relationer, kärlek och intimitet. Denna uppsats syftar till att undersöka hur filmen “Fifty Shades of Grey” romantiserar makt och kontroll genom sina visuella och narrativa uttryck. Studien ägnar särskild uppmärksamhet åt hur kontroll legitimeras och hur könsroller representeras i relationen mellan de två protagonister

With modern day interest to continue the reduction of harmful emissions and improve the efficiency of combustion devices, the need to further improve upon accuracy and ability to describe combustive processes is of high value. Nowadays, multiple capable point (0D) and two-dimensional measurement (2D) techniques exist for flame investigation, however as combustion nearly always is a three-dimension

This thesis orbits around the changes in the Swedish abortion laws during the last century, and the relation to religion. The aim is to make visible the values enshrined in the first abortion law, and those in the current abortion law, as the legislation made a volte-face in the 1970’s. Today, abortion is a right and the state is the duty-bearer. This construction collides with the conscience of r

Flyktingströmmen 2015 medförde en stor ökning av antalet asylsökande till Sverige, varav många anförde att de var ensamkommande minderåriga. Inte sällan ifrågasatte myndigheterna sökandenas åldrar, vilket medförde ett behov av åldersbedömningar. Regeringen gav då i uppdrag att skyndsamt utveckla och påbörja medicinska åldersbedömningar, och en metod för detta utvecklades hastigt. Enbart under 2017In 2015, Sweden saw a large influx of asylum-seekers into the country, many of whom claimed to be unaccompanied minor. Without personal documents to attest their age, the authorities often doubted these claims of minority, prompting a need for age assessment. The government called for medical age assessments to be developed and introduced and a method for medical age assessment was hastily develop

Background: Clinical signs are a core outcome domain for atopic dermatitis (AD) trials. The current lack of standardization of outcome measures in AD trials hampers evidence-based communication. Objective: We sought to provide evidence-based recommendations for the measurement of clinical signs in AD trials and to inform the Harmonising Outcome Measures for Atopic Dermatitis Initiative. Methods: W

The hematopoietic stem cell (HSC) is postulated to be the ultimate hematopoietic precursor providing production of mature blood cells, and is characterized by a life long capacity for self-renewal and multilineage differentiation. In a healthy human, the HSC produces 1,000,000,000,000 cells per day, illustrating the high turnover within the hematopoietic system and the need for replenishments by H

Abstract in Undetermined Background: Measured or modeled levels of outdoor air pollution are being used as proxies for individual exposure in a growing number of epidemiological studies. We studied the accuracy of such approaches, in comparison with measured individual levels, and also combined modeled levels for each subject's workplace with the levels at their residence to investigate the influe

BackgroundEvidence suggests that lifestyle activities impact cognitive and mental health in older populations. However, how lifestyle factors are associated with one another, and which factors are most important for cognitive function and mental health has received comparatively little attention.DesignBayesian-Gaussian network analysis was used to investigate unique associations between mental act

Regular exercise leads to widespread salutary effects, and there is increasing recognition that exercise-stimulated circulating proteins can impart health benefits. Despite this, limited data exist regarding the plasma proteomic changes that occur in response to regular exercise. Here, we perform large-scale plasma proteomic profiling in 654 healthy human study participants before and after a supe