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Gastroesophageal reflux disease (GERD) is a prevalent condition observed across various medical specialties, including gastroenterology, otorhinolaryngology, surgery and primary care. Despite the routine prescription of proton pump inhibitors, some patients fail to experience adequate symptom relief. This review delves into the multifactorial mechanisms of reflux, which extend beyond hydrochloric
Characterizing the onset and progression of Alzheimer’s disease pathologies relative to one another is important for biological staging and clinical trial design. Recent advances in blood plasma assays of Alzheimer’s disease amyloid and tau pathology have enabled detection of Alzheimer’s disease pathophysiology during life, but it remains unclear when plasma biomarker abnormalities are detectable
Peritoneal dialysis is a widely used, cost-effective and accessible renal replacement therapy. Theprimary aim of this thesis is to study and measure the mechanisms that govern fluid and electrolytetransport in peritoneal dialysis by combining theoretical models with experiments on rats and analysisof clinical datasets. Despite the apparent simplicity of the treatment, the physiological mechanisms
INTRODUCTION: Parents can act as important agents of change and support for healthy childhood growth and development. Studies have found that parents may not be able to accurately perceive their child's weight status. The purpose of this study was to measure parental perceptions of their child's weight status and to identify predictors of potential parental misperceptions.METHODS: We used data fro
Precise synchronization of paleoclimate records is essential for inferring the dynamics and past evolution of the climate system. For the last glacial period, the time scales of ice cores from the Greenland and Antarctic ice sheets have been synchronized by the use of cosmogenic radionuclides, atmospheric gas concentrations, and traces of large volcanic eruptions. Here we identify the sulfate depo
BACKGROUND: A significant proportion of acute myocardial infarction (AMI) patients have characteristics of high-bleeding -risk (HBR). Their influence on ischaemic and bleeding-events in AMI all-comers is not well described.METHODS: AMI Patients in England and Wales (E&W), and Sweden between 2005 and 2019 were included from MINAP and SWEDEHEART national registries. Patients were categorised acc
This article examines the transnational transfer and adaptation of the concept ‘work-related crime’ (WRC) in the Nordic context, focusing on its movement from Norway to Sweden. Drawing on interviews and document analysis, and employing the policy mobilities literature as a theoretical lens, it discusses how the WRC concept was introduced in Sweden at a time of policy-related uncertainty. The artic
This chapter summarizes the processes that are responsible for cosmogenic radionuclide variations in ice cores and the results that can be inferred from these records. The chapter starts with the production in the atmosphere caused by the influx of galactic cosmic ray particles and its modulation by the solar and geomagnetic field. Subsequently, the geochemical behavior of cosmogenic radionuclides
During periods of economic and social stability, retailers rarely need to address grocery hoarding. However, in times of crises, understanding the driving mechanisms behind hoarding becomes crucial. This study investigates the relationship between consumers’ personality traits and grocery hoarding in Sweden during the beginning of Covid-19, applying the Five-Factor Model of personality (FFM), whic
OBJECTIVES: We assessed the prevalence of neurodevelopmental disabilities (NDDs; cognition, cerebral palsy, vision/hearing, epilepsy), attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), developmental coordination disorder (DCD), behavior problems, and multimorbidity in a national cohort of children born extremely preterm (EPT, <27-week gestation) to provide a comprehe
Background: The impact of air pollution and road traffic noise on depression remains inconclusive. This study examined long-term residential exposure to air pollutants and road traffic noise in relation to dispensed antidepressant medications. Methods: A cohort study was conducted using the Swedish Malmö Diet and Cancer Study, with the outcome defined as a first dispensed antidepressant (ATC: N06A
Aims Cardiac allograft vasculopathy (CAV) is a significant complication that contributes to both morbidity and mortality after heart transplantation. The aim of this study was to (i) assess if quantitative cardiovascular magnetic resonance (CMR) myocardial perfusion could detect different stages of CAV and (ii) establish a myocardial perfusion reserve (MPR) cut-off for significant CAV. Methods and
The laterally and mutually constrained inversion (LCI and MCI) techniques allow for the combined inversion of multiple geophysical datasets and provide a sensitivity analysis of all model parameters. The LCI and MCI work with few-layered models, and are restricted to quasi-layered geological environments. LCI is used successfully for inversion of surface wave (SW) seismic data and MCI for combined
HIV-1 non-coding exon 3 can either be spliced to exons 4, 4a, 4b, 4c, and 5 to generate tat, rev, and nef mRNAs or remain unspliced to produce the 13a7 vpr mRNA. Here we show that serine-and arginine-rich proteins 55 and 75 (SRp55 and SRp75) inhibit splicing from the 5'-splice site of exon 3 thereby causing an accumulation of the partially unspliced 13a7 vpr mRNA. In contrast, serine- and arginine
Popular Abstract in Swedish Bakgrund Effekterna av en behandling vid lungsjukdomar såsom KOL (KOL = kroniskt obstruktiv lungsjukdom) och astma kan utvärderas på olika sätt och objektiva mätmetoder såsom lungfunktion används vanligen som mått på utfallet. Metoder som är rapporterade direkt av patienter är numera benämnda “Patient-reported outcome” (PRO) och är ett samlingsbegrepp för alla subjektivBackground - The effects of intervention can be evaluated in different ways, and objective measurements of changes in lung function are commonly used as the outcome measure. Patient-reported outcome (PRO) is an umbrella term used for all patient-based assessments. One important PRO is health-related quality of life (HRQL), which may be used as an evaluative or discriminative measure. Objectives -
The article investigates conceptions of freemasonry and civil society in the eighteenth century periodical Journal für Freymaurer (1784-1786).
