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Size Exclusion Chromatography (SEC) is a crucial analytical tool employed by Novo Nordisk for the assessment of potential aggregation in active pharmaceutical ingredients (API) derived from peptides and protein biopharmaceuticals. This investigation focuses on SEC analyses conducted under denaturing conditions, utilizing Ultra High-Performance Liquid Chromatography (HULK) adapted columns. Intrigui
1 Gastrointestinal infections modulate the risk for insulin autoantibodies as the first-appearing autoantibody in the TEDDY Study Short Running Title: GI infections modulate autoantibody-risk Maria Lönnrot MD PhD1, Kristian F. Lynch PhD2, Marian Rewers MD PhD3, Åke Lernmark PhD4 Kendra Vehik PhD2, Beena Akolkar PhD5, William Hagopian MD PhD6, Jeffrey Krischer PhD2, Rickhard A. McIndoe PhD7, Jorma
https://www.teddy.lu.se/sites/teddy.lu.se/files/2023-12/155_MP22b_Lonnrot_Diab%20Care_2023_Accepted%20version.pdf - 2026-07-15
Residual stresses and geometric imperfections are unavoidable consequences when manufacturing a submarine pressure hull. These effects can reduce collapse pressure by promoting earlier yielding, particularly in regions subjected to compressive stresses. In this work, nonlinear finite element analyses were performed on ring stiffened segments of a pressure hull using Abaqus to investigate how res
This edited volume critically investigates women’s knowledge about war and explores the epistemic agency of women in a range of contemporary settings across the globe. Women are deeply affected by war, participate in war and resist war. At the same time, knowledge production often ignores and marginalizes women’s experiences and gendered ways of knowing war. From Colombia to Israel and Palestine,
Eastern New South Wales (NSW), Australia, is a region prone to frequent and intense droughts. An unprecedented episode of high temperatures and low rainfall in 2017–2019 culminating in the 2019-2020 summer triggered massive canopy dieback of eucalypt forests throughout the region. Subsequent high rainfall in 2020 offered a unique and rare opportunity to study the process of vegetation recovery fol
The problems of de-blurring, de-noising, compression and segmentation are fundamental problems in image processing. Each of these problems can be formulated as a problem to find some approximation of an initial image. To find this approximation one needs to specify the approximation space and in what space the error between the image and its approximation should be calculated.Using the space of Bo
Upper-intercept U-Pb ages (TIMS) of two non-foliated I-type granites are 1887 ± 20 Ma (part of a granodiorite-granite sequence) and 1881 ± 2 Ma (leucogranite with transitions into pegmatite). A non-foliated S-granite, which according to field observations, is younger than the two I-granites, occurs within the same composite pluton. Zircons of this granite are heterogeneous and contain abundant cor
The smart city is a prominent urban development discourse that has been applied to urban policies and programs around the world. To date, there are limited empirical insights on how smart city policies and programs are leading to institutional change in urban local governance. Recent scholarship has mobilized the notion of institutional logics to unpack how the broader smart city discourse shapes
Resilience is a critical issue for water resource systems. Over the past few decades, these systems have been significantly disrupted by natural disasters and human activities, resulting in substantial economic losses. This study develops a resilience evaluation framework based on a comprehensive literature review and applies it to assess the resilience of the Yangtze River Basin (YRB). The result
We present the CH4 and N2O budgets for anthropogenic and natural sources and sinks of Australasia (Australia and New Zealand) from 2010 to 2019 using bottom-up and top-down methods, in line with the RECCAP-2 initiative, with extensions to 2022. We show that the bottom-up CH4 budget for Australasia (2010–2019) was a net source of 14.1 ± 5.5 Tg CH4 yr−1, with Australia and New Zealand contributing 8
This study investigates properties of mastics produced with 70/100 neat bitumen, three mineral fillers (granite, quartz-granite, and diorite), and a lime-based active filler at filler-to-bitumen (F/B) ratios of 40%, 50%, and 60%. The physical, geometrical, and mineralogical properties of the fillers were assessed. Their influence on mastics' behaviour was evaluated using conventional penetration a
Neural induction is a process where naive cells are converted into committed cells with neural characteristics, and it occurs at the earliest step during embryogenesis. Although the signaling molecules and chromatin remodeling for neural induction have been identified, the mutual relationships between these molecules are yet to be fully understood. By taking advantage of the neural differentiation
Increasing drought frequency and intensity affect biophysical functions of natural ecosystems. In tropical semi-arid savannas, while immediate drought effects are well-studied, the drought legacy effects on vegetation composition and associated ecosystem functions remain unclear. We used data of vegetation composition, net ecosystem CO 2 exchange, surface albedo and evapotranspiration (ET) in 201
This book examines how Gustav Radbruch, H. L. A. Hart, and Ernst-Wolfgang Böckenförde each addressed the question of the end of law, its function, and its normative foundation within the context of the modern legal and political order. Through a politico-theological reading, it highlights the tension between legal validity and moral legitimacy, as well as the extent to which law can maintain publi
Detailed longitudinal dynamics simulations may be used to predict the energy performance of road vehicles. However, including uncertainty in the operating conditions often implies high computational costs. Model-based formulations, in conjunction with statistical methods, may obviate this limitation by directly accounting for stochasticity, thus eliminating the need for simulating large population
Study region: Lake Vänern, the largest lake in the European Union, located in Sweden. Study focus: The study aimed to develop a spatially complete and temporally continuous lake surface water temperature (LSWT) dataset by fusing satellite remote sensing data with reanalysis products. Five satellite-derived LSWT products, including the Moderate Resolution Imaging Spectroradiometer (MODIS), were eva
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of pain and sedation management for screening or treatment of retinopathy of prematurity in preterm infants compared to placebo, no intervention, or other interventions.
The transport of biodegradable dissolved organic carbon (bDOC) across land-water boundaries is central to supporting the ecological and biogeochemical functioning of freshwater ecosystems. Yet, we know little about how the generation and supply of terrestrial bDOC to streams and lakes is regulated by the physical, biological, and hydrological properties of the riparian interface. Here, we assessed
