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Enantioselective synthesis is an important research topic with applications in drug development. Asymmetrical catalysis is one of the available ways of producing enantioenriched products. C2-Symmetric dibenzo[a,e]cyclooctenes or dbCOTs are a family of versatile chiral ligands for transition metals. They display great efficiency and enantioselectivity in 1,2- and 1,4- additions reactions. In this
The structure and dynamics of isolated Stratum Corneum lipids in different temperatures and hydration conditions was investigated using natural abundance 13 C NMR and X-ray scattering. In order to isolate the lipids a new extraction method was tested. The novel aspect of this method was its ability to extract more lipids from SC. This new method (referred to as Method II in-text) was further modif
Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a profound impact on clinical outcomes in cancer patients. At decreased oxygen tensions, hypoxia-inducible factors (HIFs) 1 and 2 are stabilized and mediate a hypoxic response, primarily by acting as transcription factors. HIFs exert differential effects on tumor growth and affect important cancer hallmarks in
This paper presents results from time-optimal path tracking for industrial robots. More specifically, three subproblems are studied and experimentally evaluated. The first is a contact-force control approach for determining the geometric robot motion, such that the tool centre point of the robot is moved according to the specification. The second problem is off-line solution of the optimisation pr
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The chapter studies the relationship between inequality and institutional change in the long-run. The key message is that societies change slowly and unpredictably because of path dependency of economic, political, and social institutions. Prevalent inequalities between different groups rooted in history may help to explain why change does not take place. This has implications for the results that
This paper deals with the problem of reconstructing the locations of a number of points in space from three different images taken by uncalibrated cameras. It is assumed that the correspondences between the points in the different images are known. In the case of six points this paper shows that there are in general three solutions to the problem of determining the shape of the object, but some of
Popular Abstract in Swedish Bindväv är ett samlingsnamn för vävnader som ger form och struktur i olika organ i kroppen. I brosk och ben utgör bindväven hela eller stora delar av organet, medan i andra organ, t.ex. muskel, är bindväven endast en liten del. Bindväv karaktäriseras av ett nätverk av proteiner och polysackarider (extracellulär matrix), som omger och produceras av en relativt liten andeThis thesis describes the structure and interactions of a novel extracellular matrix protein - PRELP (proline arginine-rich end leucine-rich repeat protein). The amino acid sequence of PRELP showed that it belonged to the leucine-rich repeat (LRR) protein family in connective tissues. The main part of PRELP is composed of 10 LRRs flanked by disulfide bridges at the amino- and carboxy-terminal end
Popular Abstract in Swedish På senare tid har ett stort antal receptorer för extracellulära nukleotider (P2 receptorer) klonats vilka förmedlar en mängd effekter i hjärtkärlsystemet: inotropa effekter på hjärtat, trombocytaggregation, blodtrycksreglering, frisättning av endoteliala faktorer och stimulering av glatt muskeltillväxt. Redan idag står det klart att P2-receptorer är fysiologiskt och patP2 receptors mediate the actions of the extracellular nucleotides ATP, ADP, UTP and UDP regulating several physiological responses including cardiac function, vascular tone, smooth muscle cell (SMC) proliferation, platelet aggregation, and the release of endothelial factors. The aim of the present study was to investigate the mRNA and protein expression of P2 receptors in human SMCs, endothelial c
Growth theory predicts that poor countries will grow faster than rich countries. Yet, growth in developing countries has been consistently lower than growth in developed countries. The poor economic performance of developing countries coincides with both long-lasting and short-lived financial crises. In this paper, we analyze to what extent financial crises can explain low growth rates in developi
