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The clustering of certain proteins into oligomers and fibrils, known as amyloids, underlies the pathology of diseases such as Alzheimer’s disease, Parkinson’s disease, and type 2 diabetes. These processes are counteracted by the cellular protein quality control system, which includes molecular chaperones that interact with disease-associated proteins. One such chaperone is DNAJB6b, which has gaine

This study introduces the novel concept of the justice/participation paradox to post-conflict peace and justice literature. The 2016 peace agreement between the Colombian government and the Revolutionary Armed Forces of Colombia (FARC) formalised a solution to the peace-versus-justice dilemma: allocating congressional seats to FARC while ensuring legal accountability through the Special Jurisdicti

This narrative Review explores the role of hyperinsulinaemia as a potential independent contributor to obesity and cardiometabolic diseases. We argue that scientific discussions about the role of hyperinsulinaemia as a causal factor in these conditions have not sufficiently distinguished between postprandial insulin excursions and chronically elevated basal levels of insulin. We summarize findings

High-energy hadronic collisions generate environments characterized by temperatures above 100 MeV (refs. 1,2), about 100,000 times hotter than the centre of the Sun. At present, it is therefore unclear how light (anti)nuclei with mass number A of a few units, such as the deuteron, 3He or 4He, each bound by only a few MeV, can emerge from these collisions3,4. Here, the ALICE Collaboration reports t

Geographers have shown how mobile phones are transforming urban economies in Africa by altering the temporal and spatial nature of commercial transactions. Less well documented is how young people in Africa are using mobile phones to navigate the interplay between personal hopes, social expectations, and financial uncertainty associated with urban life. Drawing on qualitative data from youth in tw

A growing class of small RNAs, known as tRNA-derived RNAs (tdRs), tRNA-derived small RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA degradation. These small RNAs have recently been implicated in an evolutionarily conserved repertoire of biological processes. In this Review, we discuss the biogenesis and molecular functions of tdRs in mammals, including tdR-med

Simultaneous shape and topology optimization is used to design pressure-activated inflatable soft robots. The pressure loaded boundary is meshed conformingly and shape optimized, while the morphology of the robot is topology optimized. The design objective is to exert maximum force on an object, i.e. to produce soft “grippers”. The robot's motion is modeled using nearly incompressible finite defor

The tourism industry, destinations, and the wider tourism community and stakeholders face several significant short and long-term challenges that will substantially affect the future direction of tourism. Issues of social, economic, and environmental change are further complicated by current geopolitical conflicts and competition. These issues raise important questions with respect to the role of

Background and aim: To date, few studies have focused on the health effects of pesticide exposure among avocado farmworkers. We examined the association of exposure to insecticides, fungicides, and herbicides with cognitive and mental health outcomes among these avocado workers from Michoacan, Mexico. Materials and methods: We conducted a cross-sectional study of 105 avocado farmworkers between Ma

Hollow microgels are fascinating model systems at the crossover between polymer vesicles, emulsions, and colloids as they deform, interpenetrate, and eventually shrink at higher volume fraction or when subjected to an external stress. Here, we introduce a system consisting of microgels with a micrometer-sized cavity enabling a straightforward characterization in situ using fluorescence microscopy

We combine small-angle scattering experiments and simulations to investigate the internal structure and interactions of composite poly(N-isopropylacrylamide)-poly(ethylene glycol) (PNIPAM-PEG) microgels. At low temperatures the experimentally determined form factors and the simulated density profiles indicate a loose internal particle structure with an extended corona that can be modeled as a star

Antibiotics that are efficacious for infectious pancreatitis are present in pancreatic exocrine secretion (PES) after intravenous administration and above minimal inhibitory concentrations. We measured concentrations of four antibiotics by tandem liquid chromatography–mass spectroscopy in plasma and PES after enteral administration to juvenile pigs with jugular catheters and re-entrant pancreatic-

“Tin-oxo cage” organometallic compounds are considered as photoresists for extreme ultraviolet (EUV) photolithography. To gain insight into their electronic structure and reactivity to ionizing radiation, we trapped bare gas-phase n-butyltin-oxo cage dications [(BuSn)12O14(OH)6]2+ in an ion trap and investigated their fragmentation upon soft X-ray photoabsorption by means of mass spectrometry. In

INTRODUCTION: Suspected non-Alzheimer's pathophysiology (SNAP) is a biomarker driven designation that represents a heterogeneous group in terms of etiology and prognosis. SNAP has only been identified by cross-sectional neurodegeneration measures, whereas longitudinal measures might better reflect "active" neurodegeneration and might be more tightly linked to prognosis. We compare neurodegeneratio

Hydropower is one of the renewable energy sources having the highest conversion efficiency than other renewable energy sources. The hydro turbine is considered as the main component of a hydropower plant and operation and maintenance of various components are the critical issues for optimal energy generation. Under the present paper, a comprehensive literature review on the operation and maintenan

Halogen bonding is increasingly utilized in efforts to achieve high affinity and selectivity of molecules designed to bind proteins, making it paramount to understand the relationship between structure, dynamics, and thermodynamic driving forces. We present a detailed analysis addressing this problem using a series of protein-ligand complexes involving single halogen substitutions - F, Cl, Br, and