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Both in the humanities and in the sciences, researchers make mistakes, and this is an essential part of the creative process. In a wider historical perspective, dead-ends can turn out to be the way forward. Two fathers of scientific systems, Aristotle and Carl Linnaeus, serve as an argument for the thesis that errors, or what we later label as such, are a necessary element of scientific work. In
The role of substance P (SP) in allergic reactions of the skin was investigated. Spantide, a competitive inhibitor of SP, was injected intracutaneously into the volar aspect of the forearm prior to the following challenges: benzalkonium chloride (irritant delayed reaction), tuberculin (immunological delayed reaction), UVB irradiation, benzoic acid (non-immunological contact urticaria), different f
South African ball-rolling dung beetles exhibit a unique orientation behavior to avoid competition for food: after forming a piece of dung into a ball, they efficiently escape with it from the dung pile along a straight-line path. To keep track of their heading, these animals use celestial cues, such as the sun, as an orientation reference. Here we show that wind can also be used as a guiding cue
Left handedness was found to be significantly less common among patients with breast cancer in southern Sweden (1.5%) than among a female referent population (5%) (P<0.0025). The findings lend support to theories suggesting that hormonal factors in early life are of importance both for handedness and for the risk of breast cancer.
There is a long-standing economic debate to what extent interest rates are determined by domestic versus international forces. Using a time series factor model, we estimate two common global factors for the short-term real interest rate for a panel of 17 advanced economies from 1871 to 2013. Our analysis shows that more than 50% of the variation in national real interest rates can be explained by
The properties of combined multiplier and penalty function methods are investigated using a second-order expansion and results known for the Riccati equation. It is shown that the lower bound of the values of the penalty constant necessary to obtain a minimum is given by a certain Riccati equation. The convergence rate of a common updating rule for the multipliers is shown to be linear.
The convergence properties of different updating methods for the multipliers in augmented Lagrangians are considered. It is assumed that the updating of the multipliers takes place after each line search of a quasi-Newton method. Two of the updating methods are shown to be linearly convergent locally, while a third method has superlinear convergence locally. Modifications of the algorithms to ensu
A new approach to the constrained function optimization problem is presented. It is shown that the ordinary Lagrange multiplier method and the penalty function method may be generalized and combined, and the new concept ofmultiplier function is introduced. The problem may then be converted into an unconstrained well-conditioned optimization problem. Methods for numerical solution are discussed, an
Rice, as one of the most important crops in the world, is facing an ever-accelerating challenge from climate change. Epigenetic modification with its substantially high epimutation rate and the possibility for some epigenetic variation to act as a heritable contributor to crop environmental adaptability may hold great potentials for rapid crop breeding. Epigenetic modification is controlled by epi
The possible effect of the DSM-5 impairment criterion on diagnosing autism spectrum disorder (ASD) in young children was examined in 127 children aged 20-47 months with a DSM-IV-TR clinical consensus diagnosis of ASD. The composite score of the Vineland Adaptive Behavior Scales (VABS) served as a proxy for the DSM-5 impairment criterion. When applying a mild level of impairment (cutoff: 1 SD below
Transcultural flows of capital, culture and communication have created conditions for the widespread movement of people around the globe, leading to increasing diversity in countries of destination. In contexts of global migration lingua franca English is indispensable in initial and survival communication. For migrants to northern European countries where lingua franca English functions as a 'con
Object shift (OS) is a word order phenomenon in Scandinavian languages where under some circumstances the object appears before a sentential adverb. Despite the frequent assumptions that word order is determined in syntax, and despite the link of OS and syntactic phenomena like V2, there is no consensus that OS is a syntactic phenomenon. Particularly, it has been observed that OS targets specifica
In total 14 bulk atmospheric deposition collectors were distributed over the city of Lund (about 20 km~) in the south of Sweden during September 1980 to June 1981. The observations were made to investigate small-scale spatial variability of atmospheric deposition. Monthly bulk deposition samples were analyzed for CI, Ptot, Zn, Cu, and Pb.Correlation analysis shows that the spatial scale for the va
There is ample psycholinguistic evidence that speakers behave efficiently, using shorter and less effortful constructions when the meaning is more predictable, and longer and more effortful ones when it is less predictable. However, the Principle of No Synonymy requires that all formally distinct variants should also be functionally different. The question is how much two related constructions sho
