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Multiple myeloma (MM) is a blood malignancy originating from plasma cells. First-degree relatives of patients with MM have two- to four-fold higher risk of MM. However, the molecular basis remains largely unknown. This Ph.D. project aims to identify novel DNA sequence variants predisposing to MM through genome-wide association studies (GWAS) and, subsequently, characterize identified variants func

Purpose: Blockchain technology (BCT) is argued to deliver a trustless system where trust is driven by technology rather than individuals or organizations. This paper studies this claim using insights related to tracing sustainability features in the metal industry. Methodology: The results of this study are based on multiple case studies of two supply chains (steel and copper) piloting a traceabil

This chapter focuses on the diplomatic, security, and defence dimensions of EU foreign policy. Developments in the last decade, not least Russia's annexation of Crimea, China's increasing global political - and not only economic - prevalence, and America's reoriented foreign policy all speak to this dynamic - and also render the EU a more challenging position in international relations. Recognitio

Two methods of setting clocks to show correct time during the 17th century by French Jesuits in China are investigated and their computations and accuracy are analysed. These methods were used to rectify the clocks used for timings of eclipses of the Galilean moons or for lunar eclipses that in turn were used to determine geographical longitudes by Jesuit missionaries in Siam and China. It is foun

Are there option values for transport services? A few studies have tried to answer this question through various stated preference methods, but we do not know much about its magnitude in different contexts. In this paper, we summarize the theory on option value, present previous empirical work concerning transport, and discuss its links to accessibility. Accessibility can be seen as the end produc

During a voluntary contraction, motor units (MUs) fire a train of action potentials, causing summation of the twitch forces, resulting in fused or unfused tetanus. Twitches have been important in studying whole-muscle contractile properties and differentiation between MU types. However, there are still knowledge gaps concerning the voluntary force generation mechanisms. Current methods rely on the

Humans have an impressive ability to communicate precise social intentions and desires with their voice - through vocal attitudes. Previous studies have shown how isolated acoustic features such as pitch can convey social attitudes, but have mostly worked with single attitudes and have not controlled for inter-speaker variability. Thus, the vocal behaviours used to produce social attitudes remain

Amid growing polarisation in European societies, civil society elites, encompassing resource-rich, influential and often liberal-oriented civil society organisations (CSOs), are under increased attacks by conservative and progressive actors alike. This article aims to understand who challenges civil society elites, on what grounds, and with what means do they do so in the United Kingdom, by drawin

The infrared spectra of the water (H2O, HDO, D2O) complexes with HCl, HBr, HI Cl2, Br2, and I2 have been studied in argon matrices in the 11 to 25 K interval. In all cases, water acts as a lone-pair donor. The hydrogen halide complexes are effectively planar and rotate around the axis through the heavy atoms. For the water halogen complexes, the results are less clear, but a similar rotation, coup

Background: Bladder cancer is categorized as non-muscle invasive (NMIBC) or muscle invasive (MIBC). NIMBC makes up around 70% of the cases and although it is less aggressive, the recurrence rate is 50-70%, thus requiring extensive monitoring. Additionally, there is a risk of progression into MIBC with a 5-year survival of only 50% even when treated with radical cystectomy. Immune checkpoint inhibi

BACKGROUND AND AIMS: Systolic blood pressure (SBP) drops recorded by 24-hour ambulatory blood pressure (BP) monitoring (ABPM) identify patients with susceptibility to reflex syncope and orthostatic intolerance. We tested the hypothesis that treatments aimed to increase BP (reassurance, education & life-style measures plus pharmacological strategies) can reduce SBP drops.METHODS: Multicentre, o

Purpose: This article reports on jaw articulation, in connection with the segmental articulations of tongue tip and lips. The jaw is considered a syllable articulator as it opens and closes for each syllable, and the amount of jaw opening is related to syllable strength, given the same phonemic vowel. Here, we investigate the syllabic and the segmental articulations relationships to the acoustic s

Engraved ochres and ostrich eggshells from the South African Blombos Cave and Diepkloof Rock Shelter are among the earliest expressions of human symbolic behavior. Furthermore, they appear to document a continuous practice of abstract mark-making across ~40.000 years. During this time, the engraved patterns change from simpler unstructured patterns to complex, ordered and symmetric cross-hatchings

Aims and background: Whole-genome sequencing (WGS) is increasingly applied in clinical practice and expected to replace standard-of-care (SoC) genetic diagnostics in hematological malignancies. This study aims to assess and compare the fully burdened cost (‘micro-costing’) per patient for Swedish laboratories using WGS and SoC, respectively, in pediatric and adult patients with acute lymphoblastic