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AIMS/HYPOTHESIS: To study the heritability and familiality of type 2 diabetes and related quantitative traits in families from the Botnia Study in Finland. METHODS: Heritability estimates for type 2 diabetes adjusted for sex, age and BMI are provided for different age groups of type 2 diabetes and for 34 clinical and metabolic traits in 5,810 individuals from 942 families using a variance compone
It is yet unknown to which degree young subfertile men present with signs of hypogonadism and whether low testosterone concentration, like in older men, is associated with risk of osteoporosis and metabolic derangements in those subjects. The objective was, therefore, to investigate the prevalence of hypogonadism and its association with metabolic and bone parameters in young subfertile men.
OBJECTIVE: To investigate metabolic factors and their possible impact on risk of thyroid cancer. METHODS: A prospective cohort study was conducted based on seven population-based cohorts in Norway, Austria, and Sweden, in the Metabolic syndrome and Cancer project (Me-Can). Altogether 578,700 men and women with a mean age of 44.0 years at baseline were followed for on average 12.0 years. Relative r
CAPS1 and CAPS2 regulate dense-core vesicle release of transmitters and hormones in neuroendocrine cells, but their precise roles in the secretory process remain enigmatic. Here we show that CAPS2(-/-) and CAPS1(+/-);CAPS2(-/-) mice, despite having increased insulin sensitivity, are glucose intolerant and that this effect is attributable to a marked reduction of glucose-induced insulin secretion.
OBJECTIVES: To investigate sick leave and disability pension in working-age subjects with knee osteoarthritis (OA) compared with the general population. METHODS: Population-based cohort study: individual-level inpatient and outpatient Skåne Health Care Register data were linked with data from the Swedish Social Insurance Agency. In 2009 all working-age (16-64 years) Skåne County residents who i
Background The impact of the prophylactic vaccine against human papillomavirus (HPV) types 6, 11, 16, and 18 (HPV6/11/16/18) on all HPV-associated genital disease was investigated in a population that approximates sexually naive women in that they were "negative to 14 HPV types" and in a mixed population of HPV-exposed and -unexposed women (intention-to-treat group). Methods This analysis studied
The optical spectra of a quantum cascade laser structure under nonequilibrium conditions is studied using the technique of nonequilibrium Green functions. We focus on the impact of Coulomb corrections and their dependence on the operating conditions. The role of the static mean field due to the charge distribution by electrons and ioninzed donors is investigated.
Climate change loss and damage research and policy includes biodiversity loss as a non-economic loss and damage. Yet there is scant understanding of what is loss and damage in tropical fisheries and how it is measured. We conduct the first systematic review of loss and damage in fisheries. The study uses a qualitative interpretivist values–based lens to examine fishers’ intrinsic, instrumental, an
Aging profoundly affects the immune system leading to an increased propensity for inflammation. Age-related dysregulation of immune cells is implicated in the development and progression of numerous age-related diseases such as: cardiovascular diseases, neurodegenerative disorders, and metabolic syndromes. Monocytes and monocyte-derived macrophages, being important players in the inflammatory resp
The 1970s saw the rise of two unrelated and yet affine historical concepts: Late Antiquity (Brown 1971) and Post-Modernism (Lyotard 1979). It is almost as if the breakdown of Antiquity in the way it had been traditionally understood, clearly delineated from the Middle Ages and the Byzantine Empire, heralded the dissolution of the Modern Western self-understanding and everything that went with it.
To find means of controlling the size and density of particles intended for inhalation the relationship between droplet and particle size during spray drying was investigated. Lactose solutions were atomized with a two-fluid nozzle and dried in a laboratory spray drier. The effects of nozzle orifice diameter, atomization airflow and feed concentration on droplet and particle size were examined. Ma
Denna avhandling undersöker performativa protesters möjligheter att utmana epistemiskt våld och omforma antagonistiska relationer genom agonistiskt engagemang i den djupt asymmetriska och polariserade kontexten i Palestina och Israel. Studien baseras på etnografiska fältarbeten – inklusive 35 intervjuer och 57 deltagande observationer – genomförda på olika platser i städer såsom Jerusalem, Tel AviThis dissertation explores the potential of performative protest to challenge epistemic violence and reconfigure antagonistic relations through agonistic engagement in the deeply asymmetrical and polarised context of Palestine and Israel. Drawing on multi-sited ethnographic fieldwork—including 35 interviews and 57 participant observations—conducted across diverse locations such as Jerusalem, Tel A
The formation of the intermetallic 𝜎 phase (space group 𝑃42/𝑚𝑛𝑚) has a detrimental effect on the ductility of transition-metal alloys. This theoretical study uses first-principles calculations to investigate the stability and thermodynamic properties of the WRe and WOs 𝜎 phases. Our study indicates that the 𝜎 phase becomes thermodynamically stable at its ideal composition for temperature
BackgroundPain is prevalent in spina bifida (SB), yet, it has received limited attention in research and healthcare.ObjectiveTo investigate pain severity, common pain sites, and pain interference with daily activities and sleep in individuals with SB.MethodsLiterature was last searched in Scopus, Web of Science, Embase, PubMed, CINAHL, and Academic Search Complete in July 2024. Inclusion criteria
The Swedish brothers Magnus (Johannes, 1488–1544 and Olaus, 1490–1557) are best known as the authors of two enormous works on Swedish and Scandinavian history. They spent a considerable part of their lives in the shadow of the advent of Lutheranism in Sweden, which was a crisis on a political, religious, and personal level for the brothers, being devout Catholics. Johannes arrived in Sweden in 152
