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Using population-based data from Sweden, we identified all multiple myeloma (MM) patients (n = 8740) and 5652 monoclonal gammopathy of undetermined significance (MGUS) patients diagnosed between 1986 and 2005. We calculated standardized incidence rates (SIRs) for all subsequent hematologic and nonhematologic malignancies for MM patients diagnosed before/after 1995 (introduction of high-dose melpha
OBJECTIVE: To examine the risk of prostate cancer in relation to pre-diagnostic serum levels of vitamin D (25OHD(2) and 25OHD(3)), PTH, and calcium. METHODS: Nine hundred forty-three incident prostate cancer cases were identified in the Malmö Diet and Cancer Study cohort, and each was matched with one control using incidence density matching with age as the underlying timescale. We also matche
Background Carriers of APOE epsilon 2 and epsilon 4 have an increased risk of intracerebral haemorrhage (ICH) in lobar regions, presumably because of the effects of these gene variants on risk of cerebral amyloid angiopathy. We aimed to assess whether these variants also associate with severity of ICH, in terms of haematoma volume at presentation and subsequent outcome. Methods We investigated the
Do women who have diabetes before menopause have their menopause at an earlier age compared with women without diabetes?
In development, epigenetic mechanisms such as DNA methylation have been suggested to provide a cellular memory to maintain multipotency but also stabilize cell fate decisions and direct lineage restriction. In this study, we set out to characterize changes in DNA methylation and gene expression during granulopoiesis using 4 distinct cell populations ranging from the oligopotent common myeloid prog
Developmental theorists have proposed for a long time that the prevailing focus on stable individual differences has obstructed the discovery of short-term covariations between cognitive performance and contextual influences within individuals that may help to uncover mechanisms underlying long-term change. As an initial step to overcome this imbalance, we observed measures of motivation and worki
BACKGROUND: The metabolic syndrome (MetS) has been related to an increased risk of colorectal cancer, but the modest size of previous studies precluded detailed characterization of the role of individual MetS factors and their interaction on risk. METHODS: In the Metabolic Syndrome and Cancer Project (Me-Can), data on body mass index (BMI), blood pressure, and blood levels of glucose, cholesterol,
Ribosomal protein L12 is a two-domain protein that forms dimers mediated by its N-terminal domains. A 20-residue linker separates the N- and C-terminal domains. This linker results in a three-lobe topology with significant flexibility, known to be critical for efficient translation. Here we present an ensemble model of spatial distributions and correlation times for the domain reorientations of L1
An improved knowledge of how contrasting types of plant communities and their associated soil biota differ in their responses to climatic variables is important for better understanding the future impacts of climate change on terrestrial ecosystems. Elevational gradients serve as powerful study systems for answering questions on how ecological processes can be affected by changes in temperature an
Original connections among the world's extant Archean cratons are becoming tractable by the use of integrated paleomagnetic and geochronologic studies on Paleoproterozoic mafic dyke swarms. Here we report new high-quality paleomagnetic data from the similar to 2.41 Ga Widgiemooltha dyke swarm of the Yilgarn craton in western Australia, confirming earlier results from that unit, in which the primar
Pressure drop and convective heat transfer characteristics of water and five alumina/water nanofluids of weight concentrations from 0.78% wt. to 7.04% wt. were experimentally investigated for both laminar flow and turbulent flow inside a double-pipe helically coiled heat exchanger. Effect of nanoparticles on the critical Reynolds number is negligible. A new correlation was developed for laminar fl
Background: Smoking is not associated with prostate cancer incidence in most studies, but associations between smoking and fatal prostate cancer have been reported. Methods: During 1992 and 2000, lifestyle information was assessed via questionnaires and personal interview in a cohort of 145112 European men. Until 2009, 4623 incident cases of prostate cancer were identified, including 1517 cases of
The cost of treating cardiovascular disease (CVD) and diabetes is enormous and is set to rise in the coming years. Physical inactivity and sedentary behaviors are major risk factors for these diseases and are estimated to account for several million global deaths annually. Lifestyle interventions, particularly those aimed at enhancing physical activity levels, have a substantial favorable impact o
Production of protein is often accompanied with difficulties due to the large amounts of different biological material resulting from fermentation. This makes purification necessary and affinity chromatography is usually involved as being biospecific, although suffering from limitations as low recovery due to ineffective elution and inability to handle particulate materials. Displacement of lactat
Popular Abstract in Swedish Vår läkemedelsanvändning har eskalerat de senaste två årtionden och vi har kunnat behandla, bota och förebygga sjukdomar samt minskat antalet oönskade graviditeter i större utsträckning jämfört med förr. Detta har dock också fört med sig negativa effekter och miljöproblem efter att läkemedlen kommer ut i naturen. Ett antal läkemedel är så kallade endokrina störningssubsSynthetic hormones are a group of pharmaceuticals used for various human and animal treatments. However, consumption and disposal of these substances have also given rise to negative effects and environmental problems for organisms in the wild which is why these substances have been classified as estrogenic endocrine-disrupting chemicals (EDCs). Studies on the estrogen receptors (ers) and their ge
This thesis is concerned with two aspects of peripheral nerve injury. First the early changes in the gene expression of the dorsal root ganglion (DRG) in response to sciatic nerve injury as revealed by micro-array analysis. Second an examination of the effect of PAI-1 and amphiregulin on survival and axonal outgrowth from DRG. Based on the micro-array analysis, performed on DRG 12 h and 24 h post
Popular Abstract in Swedish Allteftersom kraven på kvalité och prestanda hos dagens produkter ökar används alltmer avancerade material som en del av modern produktion. Problemet som uppstår är dock att dessa material ställer nya krav på tillverkningsprocessen och då inte minst vid skärande bearbetning. Trots att en betydande mängd forskning redan har publicerats vad gäller skärande bearbetning av As quality and performance demands on today’s products increases, more and more advanced materials are being used during modern production. The problem is however that this in turn place new demands on the machining processes utilized. Even though a significant amount of research has been published on the machining of these materials knowledge is still limited in several crucial areas. A problem w
The near-infrared spectrum of upsilon Sagittarii has been registered using the SOFIN high resolution spectrometer on the Nordic Optic Telescope, La Palma. For the first time 4f-5g transitions of Fe II in any astrophysical spectrum have been identified. Optical region spectra with the high resolution SOFIN spectrograph have been analysed for determination of elemental abundances and spectral line i
