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BACKGROUND: The minor T allele of rs2943641 near the gene encoding for insulin receptor substrate 1 (IRS1) has been associated with decreased risk of type 2 diabetes (T2D) and adiposity in genome-wide association studies. Dietary intake can influence the regulation of IRS1, and studies have indicated sex-specific associations between IRS1 and adiposity. OBJECTIVE: The objective was to examine the
Both pathological excess and deficiency of growth hormone (GH) are associated with cardiovascular mortality.
By studying the continuity between the Ottoman Empire and its succeeding Turkish Republic, this article aims to address one crucial aspect of the denial of the Armenian genocide by the Turkish state, namely the issue of state responsibility. There are psychological barriers in Turkey which have largely suppressed the memories of possible wrongdoings during World War I and the ensuing ‘Independence
Background: Age at first and last birth and the number of children are known to influence the risk of endometrial and ovarian cancers. However, it remains unknown whether the difference in years between first and last childbirth plays a role. The Swedish Family-Cancer Database allowed us to carry out the largest study ever on reproductive factors in these cancers. Material and methods: We selected
Impact of SBP vs. DBP decrement during orthostasis on cardiovascular events in hypertension is not clear.
What have the EU institutions done to safeguard rule of law values in Poland and Hungary? The goal of this thesis is to examine how Hungary and Poland have acted in ways that contradict EU values of rule of law, as well as what the EU institutions have done to safeguard these principles legislated in the Union's rule of law principle. Using a modified theory of external governance to explain i
This study examines how data governance is enacted in practice for HR data access and use in Business Intelligence (BI) systems within a public sector organization. Using data governance theory, access control models, the CIA triad, and socio-technical systems theory, the study explores the gap between formal governance structures and everyday organizational practice. A qualitative, interpretive s
BACKGROUND: Community studies have documented prevalence rates of psychological disorders among older individuals. Further, a growing number of studies have examined depression in older medical patients. However, little is known about the prevalence of a broad range of psychological disorders and psychosocial stressors among older primary care patients. The purpose of the present study was to char
Psychological models of pediatric obsessive-compulsive disorder (OCD) place a heavy emphasis on harm avoidance as a maintaining factor and target for treatment. Incompleteness and disgust may also play a role in pediatric OCD but remain under studied. Youth with OCD (n=100), anxiety disorders (n=96), and no psychiatric disorder (n=25) completed self-report measures of trait-level incompleteness, h
Background: This study aimed to investigate the relevance of various predictors of mortality in late life. Additionally, it explored whether mental health indicators such as depressive symptoms, and cognitive ability, which are known predictors of healthy ageing, are also important markers of mortality. By examining both physical and mental health indicators, we aimed to gain a more comprehensive
Although leuprorelin acetate, a luteinizing hormone-releasing hormone agonist, has been approved based on short-term clinical trials conducted in Japan, its long-term efficacy on physical function remains unclear. We aimed to evaluate the long-term therapeutic efficacy of leuprorelin acetate using real-world clinical data through a self-controlled trend-shift analysis. The analysis included 91 gen
Objective: To investigate prevalence and clinical correlates of serum C1q and anti-C1q antibody titres in black South Africans with systemic lupus erythematosus (SLE). Methods: Cross-sectional study of 96 SLE patients, 49 with lupus nephritis (LN). Anti-C1q antibodies were tested by ELISA. Serum C1q was measured as a percentage of normal by immunoelectrophoresis. Disease activity was assessed usin
There is an increasing focus on the importance of reducing red meat consumption for environmental as well as health reasons. In this study, we have assessed how consumers' choice of protein source in a meal could be affected by two nudging tools. The first nudge consisted of serving a plant-based steak as the default option instead of beef, alongside placing the plant-based steak at the top of theThere is an increasing focus on the importance of reducing red meat consumption for environmental as well as health reasons. In this study, we have assessed how consumers' choice of protein source in a meal could be affected by two nudging tools. The first nudge consisted of serving a plant-based steak as the default option instead of beef, alongside placing the plant-based steak at the top of the
The extent to which public health interventions and medical innovations have improved population health has long been debated. This thesis addresses this question by examining anti‑tuberculosis (TB) campaigns—often considered the first modern public health campaigns—through the case study of twentieth‑century Sweden.The thesis begins by documenting the rise and fall of Sweden’s anti‑TB campaigns,
Tactile perception can be investigated through ex vivo friction measurements using a so–called ForceBoard™, providing objective assessments and savings in time and money, compared to a subjective human panel. In this work we aim to compare excised skin versus VitroSkin® as model substrates for tactile friction measurements. A further aim is to detect possible differences between traditional surfac
In the shadow of industry, the service sector substantially expanded during the late nineteenth century. This paper analyzes how the creation of industrial employment contributed to this growth of services. I leverage full-count census data from the United States, Great Britain, and Sweden to estimate local employment multipliers. I show that industrial growth was a key driver in the emergence of
The presence of Shii communities in Europe is increasingly felt, especially as they establish independent religious and social infrastructures. Supporters of different Shii–Islamist political parties have established transnational links connecting diasporic communities with their countries of origin. These links have shaped and been shaped by religious, political and social dynamics in the Middle
Ultra-short period planets (USPs) have orbital periods of less than 1 d. Since their masses and radii can be determined to a higher precision than long-period planets, they are the preferred targets to determine the density of planets which constrains their composition. The K2-106 system is particularly interesting because it contains two planets of nearly identical masses. One is a high-density U
