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This study aims to investigate the different behaviors with respect to safety measures related to the interaction of e-scooters and bikes with cars in mixed traffic. E-scooters are relatively new vulnerable road users, and their behavior is still not fully understood. For this purpose, an observational study was carried out at an unsignalized at-grade intersection in the city of Catania, Italy. A

BACKGROUND: The global pandemic caused by a RNA virus capable of infecting humans and animals, has resulted in millions of deaths worldwide. Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infects the lungs, and the gastrointestinal tract to some extent. Rapid structural mutations have increased the virulence and infectivity of the virus drastically. One such mutated strain known as

Despite the immense importance of enzyme-substrate reactions, there is a lack of general and unbiased tools for identifying and prioritizing substrate proteins that are modified by the enzyme on the structural level. Here we describe a high-throughput unbiased proteomics method called System-wide Identification and prioritization of Enzyme Substrates by Thermal Analysis (SIESTA). The approach assu

In actin from many species H73 is methylated, but the function of this rare post-translational modification is unknown. Although not within bonding distance, it is located close to the gamma-phosphate of the actin-bound ATP. In most crystal structures of actin, the delta1-nitrogen of the methylated H73 forms a hydrogen bond with the carbonyl of G158. This hydrogen bond spans the gap separating sub

This reply explores issues with documenting prosodic structures given their unique relationship with metalinguistic knowledge. New evidence and perspectives are incorporated into a deeper investigation of Budai Rukai and the analytical decisions that underlie its reanalyzed prosodic system. This case study is then taken as a basis for discussion of a possible standardized protocol for the document

This present contribution presents an approach to making rational choices in face of cluelessness, focusing on effective altruism. I begin by illustrating how effective altruism faces the challenge of cluelessness, which implies a particular kind of incompleteness I call practical incompleteness. I then argue that this is not a reason for proponents of effective altruists to become skeptics, but r

Alzheimer’s disease can be treated by targeting amyloid-β plaques and diagnosed in vivo by biomarkers, prompting the revision of criteria for the diagnosis and staging of this disease.

Increasing climatic and human pressures are changing the world's water resources and hydrological processes at unprecedented rates. Understanding these changes requires comprehensive monitoring of water resources. Hydrogeodesy, the science that measures the Earth's solid and aquatic surfaces, gravity field, and their changes over time, delivers a range of novel monitoring tools that are complement

Objectives. To estimate the incidence and prevalence of multiple sclerosis (MS) in Malmö municipality in southwestern Sweden. Materials and Methods. Multiple sources were used in the case identification process. Case ascertainment was assessed by medical chart review including examinations such as magnetic resonance imaging, cerebrospinal fluid analyses, and relevant laboratory tests. Cases were c

Weather climate fluctuations cause large variations in renewable electricity production, which requires substantial amounts of energy storage to overcome energy drought periods. Based on daily hydroclimatic data and information about renewable power systems covering Europe, here we quantify the complementarity in the solar-wind-hydro energy components of the continental climate system. We show tha

The enzymes that facilitate phosphate and sulfate hydrolysis are among the most proficient natural catalysts known to date. Interestingly, a large number of these enzymes are promiscuous catalysts that exhibit both phosphatase and sulfatase activities in the same active site and, on top of that, have also been demonstrated to efficiently catalyze the hydrolysis of other additional substrates with

Recent years have witnessed an explosion in computational power, leading to attempts to model ever more complex systems. Nevertheless, there remain cases for which the use of brute-force computer simulations is clearly not the solution. In such cases, great benefit can be obtained from the use of physically sound simplifications. The introduction of such coarse graining can be traced back to the e

Comprehensive resource summarizing recent research on von Willebrand disease, showing clinicians how to optimize management of patients with this disorder The newly revised and updated second edition of Textbook of von Willebrand Disease: Basic and Clinical Aspects, 2nd edition describes the important and complex role of von Willebrand factor (VWF) in hemostasis and thrombosis, covering not only t

Hematopoietic stem cells (HSCs) cultured outside the body are the fundamental component of a wide range of cellular and gene therapies. Recent efforts have achieved > 200-fold expansion of functional HSCs, but their molecular characterization has not been possible since the majority of cells are non-HSCs and single cell-initiated cultures have substantial clone-to-clone variability. Using the Fgd5

This study investigates whether local government expenditure correlate with the Quality of Life (QoL) of the local population and whether high public expenditure are indicative of high or low QoL. Data, including information on public expenditure and objective QoL indicators, were gathered for Finnish municipalities from several existing databases and cover a period of 2015–2019. A composite indic