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AIMS/HYPOTHESIS: About 35% of individuals with type 2 diabetes develop persistent albuminuria, lose renal function, and are at increased risk for microvascular complications like diabetic nephropathy. Recent genome-wide association studies have identified the uromodulin locus (UMOD), encoding the most common protein in human urine to be associated with hypertension and also with chronic kidney dis
Abstract Background. The plasma level of cystatin C is a better marker than plasma creatinine for successful aging. It has been assumed that the advantage of cystatin C is not only due to it being a better marker for glomerular filtration rate (GFR) than creatinine, but also because an inflammatory state of a patient induces a raised cystatin C level. However, the observations of an association be
Methylmercury is eliminated from the human body as glutathione (GSH) conjugates. GSH production is mediated by glutamyl-cysteine ligase (GCL) and conjugation by glutathione S-transferases (GST). In this study, the authors tested whether polymorphisms in GCL and GST genes modify methylmercury retention. Erythrocyte mercury concentration (EryHg), plasma polyunsaturated fatty acids (PPUFA), and genot
In this paper, physical limitations on bandwidth, realized gain, Q-factor and directivity are derived for antennas of arbitrary shape. The product of bandwidth and realizable gain is shown to be bounded from above by the eigenvalues of the long-wavelength, high-contrast polarizability dyadics. These dyadics are proportional to the antenna volume and are easily determined for an arbitrary geometry.
This study was aimed at investigating the outcomes of an activity-based assessment (BIA) compared with standard assessment (SA) for evaluating clients undergoing psychiatric occupational therapy. Patients admitted to a psychiatric occupational therapy unit were randomized into the BIA or the SA assessment. The outcome indicators were (a) clients' satisfaction with the occupational therapy during t
The primary aim of this study is to view the meaning, the function and the consequences of appealed community plans. A overview of the Swedish regulations has been made in addition to an empirical study of 63 appealed community plans in two municipalities in the south of Sweden, during the years 1996-2000. The study shows that approximately 25% of all the plans made have been the object for appeal
There might be a need for support for families where the mother has an intellectual disability, in order to counteract the effects of potential parental inadequacy and other detrimental aspects of the family situation. The purpose of this study was to describe how professionals characterized such support and the collaboration required.
Summary In 1895 a posthumous essay by the Swedish poet and scholar Viktor Rydberg (1828- 1895) was published with the, for many modern Europeans, provoking title Den hvita rasens framtid (“The future of the white race”). In the late 20th century however “the white race” was a commonly used expression, it did not indicate any right-wing sympathies. Rydberg himself was a leftist, a social liberal. C
The study builds on a previous study of the everyday occupations of 100 women who worked at home and in the paid workforce. Their pattern of daily occupations was depicted using time-occupation graphs inspired by the time geography method, whereby the women’s pattern of occupations were categorised and clustered according to complexity. For each woman, the level of complexity was operationalised a
Background Union of a scaphoid fracture is difficult to assess on a standard series of radiographs. An unnecessary and prolonged immobilization is inconvenient and may impair functional outcome. Although operative treatment permits early mobilization, its influence on time to union is still uncertain. Purpose To assess union of scaphoid waist fractures based on computed tomography (CT) scan at 6 w
G protein-coupled receptor 30 (GPR30) or G protein-coupled estrogen receptor 1 (GPER1) is expressed in the vasculature, but the importance of vascular GPER1 remains to be clarified. Here we investigate effects of the GPER1 agonist G-1 on endothelial cell proliferation using mouse microvascular endothelial bEnd.3 cells. The bEnd.3 cells express mRNA for GPER1. The bEnd.3 cells expressed both ERα an
This paper presents theory and algorithms for covariance analysis and stochastic realization without any minimality condition imposed. Also without any minimality conditions, we show that several properties of covariance factorization and positive realness hold. The results are significant for validation in system identification of state-space models from finite input-output sequences. Using the R
Recent data suggest that platelets not only control thrombosis and hemostasis but may also regulate inflammatory processes such as acute pancreatitis. However, the specific role of platelet-derived mediators in the pathophysiology of acute pancreatitis is not known. Herein, we examined the role of CD40 ligand (CD40L, CD154) in different models of acute pancreatitis. Acute pancreatitis was induced
World Health Organization (WHO) has in 2013 changed the diagnostic criteria for gestational diabetes mellitus (GDM) to acknowledge the putative importance of mildly elevated fasting plasma glucose (FPG) levels on pregnancy outcomes. We aimed to determine the prevalence and risk factors of GDM using the previous WHO 1999 versus WHO 2013 criteria in North India.
Inconspicuous consumption, the habitual use of resources in daily routines, poses a challenge to sustainable consumption. For example, laundry is often the most environmentally demanding stage of clothing’s life cycle, consuming significant quantities of water, energy and chemicals. Laundry thus provides a prime example of inconspicuous consumption, from which to consider sustainability transition
In the field of biomedical X-ray imaging, novel techniques, such as phase-contrast and dark-field imaging, have the potential to enhance the contrast and provide complementary structural information about a specimen. In this paper, a first prototype of a preclinical X-ray phase-contrast CT scanner based on a Talbot-Lau interferometer is characterized. We present a study of the contrast-to-noise ra
Background: Age at first and last birth and the number of children are known to influence the risk of endometrial and ovarian cancers. However, it remains unknown whether the difference in years between first and last childbirth plays a role. The Swedish Family-Cancer Database allowed us to carry out the largest study ever on reproductive factors in these cancers. Material and methods: We selected
