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A new constraint for gamma-ray burst progenitor mass

Recent comparative observations of long-duration gamma-ray bursts (LGRBs) and core collapse supernova (cc SN) host galaxies demonstrate that these two, highly energetic transient events are distributed very differently upon their hosts. LGRBs are much more concentrated on their host galaxy light than cc SN. Here we explore the suggestion that this differing distribution reflects different progenit

Assessment of radical scavenging capacity of Agrimonia extracts isolated by supercritical carbon dioxide

The results on the extraction of natural compounds from Agrimonia eupatoria and Agrimonia procera by using supercritical carbon dioxide (SC-CO2) are presented. Two agrimony species were extracted in laboratory scale equipment at various parameters and it was found that in case of A. eupatoria the increase in extraction pressure and the addition of a co-solvent ethanol remarkably increases the yiel

Carpal tunnel syndrome in repetitive work: A follow-up study

Background The Project on Research and Intervention in Monotonous work (PRIM) studied Danish workers for 3-4years to determine the effects of monotonous work. The present study is a subset of that cohort and compares prevalence and incidence differences of carpal tunnel syndrome (CTS) between workers with highly repetitive work tasks and workers with varied work tasks. Methods The baseline study i

Conservation of seed-dispersing migrant birds in Mediterranean habitats: Shedding light on patterns to preserve processes

Migratory frugivorous birds disperse the seeds of many plant species, forming mutualistic associations that render frugivores a priority for conservation in many habitats worldwide. We analysed the distribution of seed-dispersing frugivorous passerines in southern Spain, which is an important area for the conservation of European birds during winter. Frugivorous birds showed similar regional abund

Matrix metalloproteinase inhibitor BB-3103 unlike the serine proteinase inhibitor aprotinin abrogates epidermal healing of human skin wounds ex vivo.

Several matrix metalloproteinases and serine proteinases are upregulated in migrating keratinocytes during cutaneous wound repair. Single cell culture studies indicate the necessity for matrix metalloproteinases but not for serine proteinases in keratinocyte locomotion. To account for epithelial-mesenchymal interactions, an ex vivo human skin wound model was used to investigate the contribution of

Bone loss after childhood acute lymphoblastic leukaemia: an observational study with and without GH therapy

OBJECTIVE: Bone mineral density (BMD) in survivors of acute lymphoblastic leukaemia (ALL) seems to vary with time, type of treatments and GH status. We aimed to evaluate BMD in ALL patients with growth hormone deficiency (GHD), with and without GH therapy. DESIGN: Case-control study. METHODS: 44 (21 women) GHD patients (median 25 years), treated with cranial radiotherapy (18-24 Gy) and chemotherap

Impaired contractility and detrusor hypertrophy in cavin-1-deficient mice.

Caveolae are membrane invaginations present in a variety of cell types. Formation of caveolae depends on caveolins and on the more recently discovered family of proteins known as the cavins. Genetic ablation of caveolin-1 was previously shown to give rise to a number of urogenital alterations, but the effects of cavin-1 deletion on urogenital function remain unknown. Here we characterized detrusor

What Type of Knowledge Rules Where? Legally regulated participation in a large-scale mobile infrastructure planning in Sweden

I investigate the field of tension between the national and the local level in spatial planning from a decision-making perspective. In doing so, I analyse the legal regulation for a large-scale 3G mobile infrastructure development in Sweden with a focus on how participation is expressed both in terms of the ‘law in books’ as well as empirically, ‘in action’. Theoretically, a model of decision maki

Treatment for chronic hepatitis C in a cohort of opiate substitution therapy recipients in three Swedish cities - completion rates and efficacy.

Opiate substitution treatment (OST) programs could provide opportunities for management of comorbidities, such as hepatitis C virus (HCV) infection, in people who inject drugs. We aimed to prospectively evaluate the real-life feasibility of interferon/ribavirin-based HCV treatment in OST recipients, with a special focus on psychiatric status and health-related quality of life.

The Process of Developing an Internet-Based Support System for Audiologists and First-Time Hearing Aid Clients

Background: In audiologic practice, complementary information sources and access to the clinician between appointments improve information retention and facilitate adjustment behaviors. An Internet-based support system is a novel way to support information sharing and clinician access. Purpose: This research forum article describes the process of developing an Internet-based support system for aud

Acute lung injury and ARDS in acute pancreatitis: Mechanisms and potential intervention

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in acute pancreatitis still represents a substantial problem, with a mortality rate in the range of 30%-40%. The present review evaluates underlying pathophysiological mechanisms in both ALI and ARDS and potential clinical implications. Several mediators and pathophysiological pathways are involved during the different phases o

Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression

Lymphatic vessels (LVs) play critical roles in the maintenance of fluid homeostasis and in pathological conditions, including cancer metastasis. Although mutations in ALK1, a member of the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) receptor family, have been linked to hereditary hemorrhagic telangiectasia, a human vascular disease, the roles of activin receptor-like kin

Reply to commentaries

In our response, we address four themes arising from the commentaries. First, we discuss the distinction between cognition and metacognition and show how to draw it within our framework. Next, we explain how metacognition differs from social cognition. The underlying mechanisms of metacognitive development are then elucidated in terms of interaction patterns. Finally, we consider measures of metac

Role of Deprotonation and Cu Adatom Migration in Determining the Reaction Pathways of Oxalic Acid Adsorption on Cu(111)

Scanning tunneling microscopy (STM), X-ray photoelectron spectroscopy (XPS), and first principles theoretical calculations have been used to gain insight into the fundamental processes involved in the adsorption and self-assembly of oxalic acid on Cu(111). The experimental data demonstrate that several reaction pathways are involved in the chemisorption of oxalic acid on Cu(111), one of which lead

Comparison of MEK/ERK pathway inhibitors on the upregulation of vascular G-protein coupled receptors in rat cerebral arteries

Organ culture is an in vitro method for investigating cellular mechanisms involved in upregulation of vasocontractile G-protein coupled receptors. We hypothesize that mitogen-activated-protein kinase (MEK) and/or extracellular-signal-regulated kinase (ERK) specific inhibitors will attenuate the G-protein coupled receptor expression following organ culture. Rat cerebral arteries were incubated 48 h

A 128-channel discrete cosine transform-based neural signal processor for implantable neural recording microsystems

A 128-channel neural signal processor for implantable neural recording microsystems is presented. The processor compresses the neural information of 128 simultaneous recording channels using discrete cosine transform, achieving a compression factor of 69 at the expense of a 5.6% root mean square error. The proposed processor is implemented on register transfer level and synthesized in a 65-nm comp