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It is still debated whether arterial elasticity provides prognostic information for cardiovascular risk beyond blood pressure measurements in a healthy population. To investigate the association between arterial elasticity obtained by radial artery pulse wave analysis and risk for cardiovascular diseases (CVD) in men and women. In 2002–2005, 2362 individuals (men=1186, 50.2%) not taking antihypert

Background: There is a lack of knowledge regarding siblings’ experiences of being a brother or sister of a child with a life-threatening or life-limiting condition. Siblings’ perspectives are often expressed through their parents and not by siblings themselves. Method: This study has a qualitative design within hermeneutic phenomenology. Thirteen siblings (ages 3–29) of children with cancer or gen

This article introduces a novel testing system for investigating rock hydromechanical behavior with neutron and X-ray imaging techniques. The system comprises four subsystems: an axial compression system, a confining pressure system, a fluid flow system, and a triaxial cell. In order to enable imaging with both modalities to track fluid flow and deformation in situ and 3D, the cell was designed to

In this study, a comprehensive investigation of a set of phytochemicals to identify potential inhibitors for the Forkhead box protein M1 (FOXM1) was conducted. FOXM1 is overexpressed in glioblastoma (GBM) cells and plays a crucial role in cell cycle progression, proliferation, and invasion. FOXM1 inhibitors have shown promising results in preclinical studies, and ongoing clinical trials are assess

X-ray phase-contrast imaging by grating interferometry has in the past decades been established both at synchrotron radiation sources and at conventional x-ray tubes. Due to the sensitivity to x-ray phase shifting, contrast in soft tissue has been improved significantly and the possibilities to do virtual histology of tissue biopsies are being pioneered. Constraints in the design of a grating inte

The trigeminal system is key to the pathophysiology of migraine and cluster headache, two primary headache disorders that share many features. Recently, MER proto-oncogene tyrosine kinase (MERTK), a cell surface receptor, was strongly associated with cluster headache through genetic studies. Further, the MERTK ligand galectin-3 has been found to be elevated in serum of migraine patients. In this s

In this piece, which frames the special issue “Technocultural worldings,” we build on previous editions of commentary and criticism in this journal. We propose a theoretically anchored way to systematically approach the dynamic, multidimensional, and heterogeneous technocultural communities that have created their own worldings and are engaged in complex dialectical dynamics within the contemporar

This study introduces a progressive methodology for examining the travel behaviour of bicyclists and pedestrians under both daylight and electric lighting conditions. By analysing data from naturalistic/undisturbed settings, we aimed to assess the representativeness of participant behaviour in an invited context compared to that of typical road users. This paper expands upon the methodological exp

Microbial, algal, plant and animal cells have been immobilized, with preserved viability, by entrapment in various matrices according to a new bead polymerization technique. The cell polymer/monomer mixture is kept suspended in a hydrophobic phase such as soy, paraffin, or silicon oil, tri-n-butylphosphate, or dibutyphtalate, which is compatible with the cells. The various monomers or polymers tes

In-situ measurements of the volume fraction of nanoparticles generated during the combustion of single iron particles were conducted using a high-speed light extinction method. The process of nanoparticles generation from iron particles burning under conditions of 21% oxygen concentration and ambient temperatures of 1400 K and 1850 K can be divided into three stages: acceleration of productivity,

The elucidation of premixed ethylene/air combustion mechanisms holds theoretical significance for optimizing engines such as pulse detonation engines and rotating detonation engines. The flame front structure constitutes a vital factor of premixed ethylene/air combustion mechanisms, while the prevailing planar laser-induced fluorescence techniques currently in use fall short of directly visualizin

Titanium alloys are known for being difficult to machine. Within the groups of Ti alloys, the machinability is reduced when going from the α-alloys, to α + β, and finally to near-β or β-alloys. Uncoated cemented carbide is traditionally used for machining these alloys and finding a suitable coating to improve the performance is a challenge due to the high strength of Ti alloys and the high chemica

Aim: Ultraviolet B (UVB) radiation can compromise the functionality of the skin barrier through various mechanisms. We hypothesize that UVB induce photochemical alterations in the components of the outermost layer of the skin, known as the stratum corneum (SC), and modulate its antioxidative defense mechanisms. Catalase is a well-known antioxidative enzyme found in the SC where it acts to scavenge

Background: Both caveolin-1 (CAV1) and insulin-like growth factor bindings protein 7 (IGFBP7) have been linked to angiogenesis, insulin-like growth factor (IGF) receptor 1 (IGF-1R) signaling, and the tumor microenvironment. However, CAV1 and IGFBP7 have not yet been adequately characterized and investigated as potential prognostic or treatment-predictive biomarkers at the genomic, transcriptomic,

Objectives:The Multidimensional Dyspnea Profile (MDP) comprehensively addresses dyspnea, incorporating both perceptual and affective components, and has proven effective in assessing breathlessness among patients with chronic lung conditions. Despite its validation in High-Income Countries, its applicability in Low/Middle-Income countries remains uncertain. Additionally, the MDP has not been trans

Background and Objective: Coeliac disease is a chronic, immune-mediated disorder for which the only treatment consists of lifelong strict adherence to gluten-free diet (GFD). However, there is a lack of evidence-based guidelines on the GFD dietary management of coeliac disease. This position paper, led by the Special Interest Group in coeliac disease of the European Society of Pediatric, Gastroent

In order to allow for a computationally efficient estimation of radar reflections, one commonly assumes the reflecting target to be in the far-field of the sensing array, such that the impinging wavefront is modeled as a linear phase-shift along the array. This works well in most radar scenarios, but causes significant performance degradation for close-range radar systems, wherein the curvature of

This thesis is a comprehensive analysis of the different regulatory designs and arguments shaping French law in order to hold French businesses liable for their human rights abuses occurring in global supply chains. It focuses on the innovative law proposal on the duty of vigilance for parent and ordering companies currently debated within the French Parliament, and France’s potential to make huma

Den här uppsatsen undersöker de avancerade metoder av effektivt innovationsskydd under företagskoncentrationsprövningar som finns i USA och EU. Syftet är att finna synergier mellan dessa två system och föreslå nödvändiga förbättringar av det europeiska systemet genom att introducera innovation som en reell standard för prövning, inkludera dynamisk effektivitet, omstörtande innovation och icke-prisThis thesis analyses advanced methods of effective protection of innovation in merger control in the USA and in the EU, finds synergies between the systems and suggests the necessary improvements of the European system of merger control in high technology markets: introduction of innovation as a real antitrust standard, inclusion of dynamic efficiencies, disruptive innovations and non-price consid